ID A0A2Y9N5E4_DELLE Unreviewed; 691 AA.
AC A0A2Y9N5E4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Tetratricopeptide repeat protein 39B {ECO:0000256|ARBA:ARBA00015483};
GN Name=TTC39B {ECO:0000313|RefSeq:XP_022429460.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022429460.1};
RN [1] {ECO:0000313|RefSeq:XP_022429460.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022429460.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TTC39 family.
CC {ECO:0000256|ARBA:ARBA00006400}.
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DR RefSeq; XP_022429460.1; XM_022573752.2.
DR AlphaFoldDB; A0A2Y9N5E4; -.
DR STRING; 9749.A0A2Y9N5E4; -.
DR Ensembl; ENSDLET00000030841; ENSDLEP00000028067; ENSDLEG00000020187.
DR KEGG; dle:111174682; -.
DR InParanoid; A0A2Y9N5E4; -.
DR OrthoDB; 5477282at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0010887; P:negative regulation of cholesterol storage; IEA:Ensembl.
DR GO; GO:0010874; P:regulation of cholesterol efflux; IEA:Ensembl.
DR GO; GO:0090181; P:regulation of cholesterol metabolic process; IEA:Ensembl.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR019412; Iml2/TPR_39.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR31859; TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER; 1.
DR PANTHER; PTHR31859:SF4; TETRATRICOPEPTIDE REPEAT PROTEIN 39B; 1.
DR Pfam; PF10300; Iml2-TPR_39; 1.
DR Pfam; PF13174; TPR_6; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT COILED 537..564
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 691 AA; 79360 MW; E6796A8CBDF87A9F CRC64;
MLSAAGQLLF LSSVNESLTG DQEIKQKLRI FLPFKLRIVS SFHWLLKNLV EERASSQWGY
INSFKVTAAL NLPSRVDMAT SSQHFSSFDT KQASGQHRTS NVKRSLSTKV DLRSGLEECA
MALNLFLSNK FTDALELLRP WAKDSMYHAL GYSTIVVLQA VMTFEQQDIQ NGISAMKDAL
QTCQKYRKKC TVVESFSSLL SRGSLEQLTE EEMHAEICYA ECLLQKAALT FVQDENMINF
IKGGLKIRTS YQIYKECLSI LHVIQKNKIE QRFFYEFEGG VKLGIGAFNL MLSLLPARII
RLLEFIGFSG NRELGILQLR EGALGRSMRS PLCCLTILAF HTYISLILGT GEVNVAEAES
LLEPYLQQFP NGSLMLFYHG RIELLKGNVE EAQEIFRKCI SVQEEWKQFH HLCYWELMWI
FVFQQNWREA YYYSDLLCKE SKWSKATYVF LKAAILSMLP EEDVGATKED VVTLFRQVDG
LKQRIAGKSI PTEKFAVRKA RRYSPSLPAP VKLVLPALEM MYVWNGFPLV SKRKDLSESL
LVTVEKAEAD LQSERKQVDE KAQETGTQRR NSKFVLFNKE PKQHSSDYSV DDECLVKLLK
GCCLKNLQRP LQAELCFNHV VQSEKLLKYD HYLVPFTLFE LAFLYKNQGE IDKAIKVLET
ARNNYKDYSL ESRLHFRIQA ALHLWKKPSS D
//
