ID A0A2Y9N5Y5_DELLE Unreviewed; 3907 AA.
AC A0A2Y9N5Y5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Dynein heavy chain 12, axonemal isoform X3 {ECO:0000313|RefSeq:XP_022428496.1};
GN Name=DNAH12 {ECO:0000313|RefSeq:XP_022428496.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022428496.1};
RN [1] {ECO:0000313|RefSeq:XP_022428496.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022428496.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR RefSeq; XP_022428496.1; XM_022572788.2.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 1215..1354
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1850..1998
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 691..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 549..609
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2694..2759
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3907 AA; 447648 MW; E72B4163302EF2C5 CRC64;
MSDTNKTAIA AEKEALNLKL PPIVRPLEDI GVGTPAQSKL LSYRRSKEQQ KTINQLVIEG
AKRNLARTLD KRTPSSPEPD YPPTMTSEIK KKGFNYIYLK QCVESSPIVP IQQEWLDHML
MLIPESLKEG KEREELIQSL INEVSSDFEK SMKRYLVRSA LVRPPVKWLE DEGGHLPESP
VGKGPIDCGS LKNDLSIQAR KAEEKIMNTW YPKVISLFTK KESLEGIKPE KLDAFYNCVS
TLMSNQLKEL LKRTVEGFVK LFDQEDQRGL PIFKMELTFD DDKMEFYPTF QDLEDVVLGL
VERIAEALQN VQTVPSWLSG TSTTVSLDTE LPEHVLQWAL DTLKVAVHHN LEGARKHYET
YVEKYNWLLD GTAVKLIETF QAEDHTFDEY TEFVGKFFSL ASEIMLLPQW AHFPMVRLDC
EGLKTGLTNK AKAFANILLN DIASKHRKEN ESICSEFEAI KEHALKVPET TEEMMELISY
VEKARTVRIN ELVSRIKESK RRMSYFLDVF LFPPEDLTLN SAVLMWPWKI NPIFDENDEL
LENAKHKKEN ELIEKREKLI LEVEKESRRM EEFAEFAELD HMQQYVTDVR QLQKRIQESE
EAVQFINKEE ELFRWELTKY PELDKLKVNI EPYQKFFNLV LKWQRTEKRW MDGGFLDLNG
ESMEAEVDEF SREIFKTLKF FQTKQKKELQ EKRKAAKRRS LGEEKLEEEP KENPTITMCT
AVMEQIKVIK EYIPTVSILC NPGMRTRHWK QLSEIVGYDL TPDSGTTMRK VLKLNLTPYL
EKFEVISAGA SKEFSLEKSM HTMMGTWDDI AFHISLYRDT GVCILSSVDE IQALLDDQII
KTQTMRGSPF IKPFEKEIKA WEDRLIRIQE TIDEWLKVQA HWLYLEPIFC SEDIMQQMPE
EGRQFQTVDR YWRDIMKFCT KDPKVLAVTS LTGLLEKLQN CNELLEKIMK GLNAYLEKKR
LFFPRFFFLS NDEMLEILSE TKDPLRVQPH LKKCFEGITK LEFLPNLDIK AMYSSEGERV
ELIALISTSA ARGAVEKWLI QVEDLMLQSI HDVIAAARLA YPESARRDWV REWPGQVVLC
VSQMFWTSET QEVISSGTEG LKKYYKELQD QLNDIVELVR GKLLKQTRIT LGALVTIDVH
ARDVVMDMID MGVSHDTDFQ WLAQLRYYWE YDNAHVSIIN CNVKYAYEYL GNSPRLVITP
LTDRCYRTLI GAFYLNLGGA PEGPAGTGKT ETTKDLAKAL AVQCVVFNCS DGLDYLAMGK
FFKGLASSGA WACFDEFNRI ELEVLSVVAQ QILCIQRAIQ QKIEVFIFEG TELKLNPNCF
VAITMNPGYA GRSELPDNLK VLFRTVAMMV PNYALIAEIS LYSYGFLNAK PLSVKIVMTY
RLCSEQLSSQ FHYDYGMRAV KAVLVAAGNL KLKFPNENED ILLLRSIKDV NEPKFLSHDI
PLFNGITSDL FPGVKLPEAD YHEFLECAHE ACKVHNLQPV KFFLEKMIQT YEMMIVRHGF
MLVGEPFAAK TKVLHMLADT LTLMNERGYG EEEKVIYRTV NPKSITMGQL FGQFDPVSHE
WTDGIVANTF REFALSETPD RKWVVFDGPI DTLWIESMNT VLDDNKKLCL MSGEIIQMSP
QMSLIFEAMD LSQASPATVS RCGMIYLEPS QLGWEPLVSS WLNSLKGPLQ EPDHQALLRG
LFDWLIQPTL SLRKKKCKEL IPTSDSNVVV SLTRLFEVLL CNVVENDPTS KHIRVWIMAC
FIFSLIWSIG GSCDTDGRIV FDIYIRLVIL GKDESNPIPD SVGKWECHFD EKGLVYDYMY
ELKNRGRWIH WNELIKSTNL GDKCVKIQDI IVPTMDTIRY TFLMDLSIAY AKPLLFVGPT
GTGKSVYVKN KLMNHLEKDL YFPFYVNFSA RTSANQVQNI IMARLDKRRK GVFGPPMGKK
CIIFIDDMNM PALEKYGAQP PIELLRQFFD CGNWYDLKDT SKITLVDIEL IAAMGPPGGG
RNPVTPRFIR HFNICTINTF SDETMVRIFS SIVAFYLRTR EFPPEYFLVG NQIVNGTMEI
YKQSMENLLP TPTKSHYTFN LRDFSRVIRG CLLIERDAVQ SKHTMIRLFV HEVLRVFYDR
LINDNDRFWL FTLTKNVIRD HFKESFDSIF SHLRKGNAPV TEEDLRNLMF GDYMNPDLEG
DDRVYIEIPN IHDFSDIVEQ CLDEYNQTHK TRMNLVIFRY VLEHLSRICR ILKQSGGNAL
LVGLGGSGRQ SLTRLATSMA KMQIFQPEIS KSYGMNEWRE DLKVLLRNVG MRGQKTVFLI
TDTQIKEEAF LEDIDSVLNT GEVPNIFAAD EKQEVMEGVH PVAQAGSKHD EFSPLALFAF
FVNRCKDNLH VVVAFSPIGD VFRNCLRQFP SLINCCTIDW FQPWPEDALE LVAVKFLETL
ELTEVERREI VPICKHFHTS IMHLSERFLH TLGRHNYVTA TSYLELIASF RQLLTKRQQA
IMEAKQRYVN GLDKLAFAES QVGEMKIELV QLQPKLEEAK IENAHMMQII EIESAQVEAK
REFVKFDEEI ASGKAEEAQA LKNECESDLA EAIPALEAAL SALDTLKPAD ITIVKSMKNP
PSGVKLVMAA VCVMKDIKPE KVSDPSGTGG KILDYWGPSK KLLGDMNFLR DLREYDKDNI
PVTVMQKIRG EYLTNPEFDP PKVAKASSAA EGLCKWIMAM EVYDRVAKVV APKKARLTEA
QKSLAETMEL LNQKRAELAE VEHHLENLQA TFLEKTEEKA RLEDQVELCA KKLERASKLI
GGLGGEKSRW SQAADDLQIV YENLTGDVLV SAGVIAYLGA FTAGFRQTCT EDWSMLCKQK
KIPCSEEFSL SKTLGDPVKI RAWNIAGLPT DTFSIDNGVI VNNSRRWPLM IDPQGQANKW
IKNSEKENQL SVIKLSDSDY MRTLENCIQF GTPLLLENVG EELDPSLEPL LLRQTFKQGG
IDCIRLGEVI IEYSFDFKFY ITTKLRNPHY MPELATKLSL LNFMITPEGL EDQLLGIVVA
KERPELEEER NALILQSAAN KKQLKDIEKK ILETLSSSEG NILEDESAIK VLDSAKLMSN
EITKKQQIAE KTELKIAESR EGYRPIAKHS SVLFFSIADL ANIDPMYQYS LIWFVNLYIN
SIHDSNKSKI LEKRLRYLND HFTYNLYCNI CRSLFEKDKL LFSFLLCANL LLAKKEIEYQ
ELMFLLTGGV SLKSSEKNPD PTWLQDKSWE EICRASEFPA FKGLRNHFCD NIAEWREIYN
SKEPHNAKFP APMDTMLNEL QKIIILRCLR PDKITPAITN YVTDKLGKKF VEPPPFDLTK
SYLDSNCTIP LIFVLSPGAD PMASLLKFAN DKAMSGNKFQ AISLGQGQGP IATKMINAAI
EEGTWVCLQN CHLAVSWMPM LEKICEDFSP EGCNSSFRLW LTSYPSPKFP VTVLQNGVKM
TNEPPTGLRL NLLQSYLTHP VSDPQFFNGC EGKELAWEKL LFGVCFFHAL VQERKKFGPL
GWNIPYGFNE SDLRISIRQL QLFINEYDTI PFEAISYLTG ECNYGGRVTD DWDRRLLLTM
LADFYNANII ENSHYKFSPS GNYFAPPKGT YNEYIEFIKK LPFTQHPEIF GLHENVDISK
DLQQTKILFE SLLLTQGGSK QTGSSGSADQ ILLEITKDIL NKLPNDFDIE SALLKYPVRY
EESMNTVLVQ EMERFNNLIK TIRNTLQDLK KAIKGVVVMD SALEALSGSL LVGKVPEIWA
QRSYPSLKPL GSYITDFLAR LTFLQDWYNS GKPRVFWLSG FFFTQAFLTG AMQNYARKYT
IPIDLLGYEF EVISSDTSEG TPEDGVYIHG LYLDGARWDR TSGLLAEQYP KLLFDLMPII
WIKPTKKSQI VKSNAYVCPL YKTSERKGTL STTGHSTNFV IAMLLKTDQP IQHWIKRGVA
LLCQLDD
//
