ID A0A2Y9N7Q0_DELLE Unreviewed; 1572 AA.
AC A0A2Y9N7Q0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Adhesion G protein-coupled receptor B2 isoform X5 {ECO:0000313|RefSeq:XP_022430769.1};
GN Name=ADGRB2 {ECO:0000313|RefSeq:XP_022430769.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022430769.1};
RN [1] {ECO:0000313|RefSeq:XP_022430769.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022430769.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_022430769.1; XM_022575061.2.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 4.
DR InterPro; IPR043838; AGRB_N.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR10239:SF32; ADHESION G PROTEIN-COUPLED RECEPTOR B2; 1.
DR PANTHER; PTHR10239; ISTHMIN-2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF19188; AGRB_N; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF00090; TSP_1; 4.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 4.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 4.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50092; TSP1; 4.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_022430769.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 957..978
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 990..1011
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1023..1047
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1059..1077
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1097..1120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1141..1163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 541..611
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 953..1194
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 789..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1347..1371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1411..1441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1490..1572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1522..1539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1572 AA; 171159 MW; 3ADF0484FF148BEF CRC64;
MQGQGTSRPG GPRPRVGLGS AALRAPGRRR GKGHRMTPAC PLLLSVILSL RLAAAFDPAP
SACSALASGV LYGAFSLQDL FPTIASGCSW TLENPDPTKY SLYLRFNRQE QVCAHFAPRL
LPLDHYLVNF TCLRPSPDEA EARAELGRPE EEEEEAAGLE LCGGSGPFTF LHFDKNFVQL
CLSAEPSEAP RLLAPAALAF RFVEVLLINN NNSSQFTCGV LCRWSEECGR AAGRACGFAQ
PGCSCPGETG ASPATTTPPG SPAAHTLSNA LVPGGPAPPA EADLHSGSSN DLFTTEMRYG
EEPEEEPKVK TQWPRSADEP GLYMAQTGDP AAEEWSPWSV CSLTCGQGLQ VRTRSCVSSP
YGTLCSGPLR ETRPCNNSAT CPVHGVWEEW GSWSLCSRSC GRGSRSRMRT CVPPQHGGKA
CEGPELQTKL CSMAACPVEG QWLEWGPWGP CSMSCANGTQ QRSRKCSVAG PAWATCTGAL
TDTRECGNLE CPATDGKWGP WNAWSLCSKT CDTGWQRRFR MCQATGSQGY PCEGTGEEVK
PCSEKRCPAF HEMCRDEYVM LMMWKKAAAG EVIYNKCPPN ASGSASRRCL LSAQGVAYWG
LPSFARCISH EYRYLYLSLR EHLAKGQRML AGEGMSQVVR SLQELLARRT YYSGDLLFSV
DILRNVTDTF KRATYVPSAD DVQRFFQVVS FMVDAENKDK WDDAQQVSPG SVHLLRVVED
FIHLVGDALK AFQSSLIVTD NLVISIQREP VSAVSSDITF PMRGRRGMKD WVRYSEDRLF
LPKEVLSLSS PGKPAASGTA GSLGRGRGPG TVPPGPGHSH QRLLPADPEE SSSYFVIGAV
LYRTLGLILP PPRPPLAVTS RVMTVTVRPP TQPLAEPLIT VELSYIINGT TDPHCASWDY
SRADASSGDW DTESCQTLET QAAHTRCQCQ HLSTFAVLAQ PPKDLTLELA GSPSVPLVIG
CAVSCMALLT LLAIYAAFWR FIKSERSIIL LNFCLSILAS NILILVGQSR VLSKGVCTMT
AAFLHFFFLS SFCWVLTEAW QSYLAVIGRM RTRLVRKRFL CLGWGLPALV VAVSVGFTRT
KGYGTSSYCW LSLEGGLLYA FVGPAAVIVL VNMLIGIIVF NKLMARDGIS DKSKKQRAGA
SLWSSCVVLP LLALTWMSAV LAMTDRRSVL FQALFAVFNS AQGFVITAVH CFLRREVQDV
VKCQMGVCRA DESEDSPDSC KNGQLQILSD FEKDVDLACQ TVLFKEVNTC NPSTITGTLS
RLSLDEDEEP KSCLVGPEGS LSFSPLPGNL LVPMSASPGL GEPPPPQEAN PVYMCGEGGL
RQLDLTWLQP AEPGSDGDYM VLPRRTLSLQ PGGGGGGGED APRARPEGTP RRAAKAMGHA
EGYPSFLSVD HSGLGLGPAY GSLQNPYGMT FQPPPPTPSA RQVPEPGERS RTMPRTVPGS
TMKLGSLERK KLRYSDLDFE VMHTRKRHSE LYHELNQKFH TFDRYRSQSM AKREKRWSVS
SGGAAERSVS SEKPSPGERP GLSQQRRHQS WSTFKSMTLG SLPPKPRERL ALHRAAAWEP
TEPPDGDFQT EV
//
