ID A0A2Y9NA48_DELLE Unreviewed; 903 AA.
AC A0A2Y9NA48;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Ubiquitin carboxyl-terminal hydrolase 25 isoform X4 {ECO:0000313|RefSeq:XP_022431699.1};
GN Name=USP25 {ECO:0000313|RefSeq:XP_022431699.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022431699.1};
RN [1] {ECO:0000313|RefSeq:XP_022431699.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022431699.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022431699.1; XM_022575991.2.
DR AlphaFoldDB; A0A2Y9NA48; -.
DR STRING; 9749.A0A2Y9NA48; -.
DR Ensembl; ENSDLET00000015132; ENSDLEP00000013697; ENSDLEG00000009568.
DR InParanoid; A0A2Y9NA48; -.
DR OrthoDB; 1423057at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR CDD; cd02665; Peptidase_C19I; 1.
DR CDD; cd20486; USP25_C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF666; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 25; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000313|RefSeq:XP_022431699.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 1..436
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 243..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 465..492
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 250..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 903 AA; 104760 MW; 2C9A6F0B881AD6F8 CRC64;
MRELRYLFAL LVGTKRKYVD PSRAVEILKD AFKSNDSQQQ DVSEFTHKLL DWLEDAFQMK
AEEETDEEKP KNPMVELFYG RFLAVGVLEG KKFENTEMFG QYPLQVNGFK DLHECLEAAM
IEGEIESLHS ENSGKSGQEH WFTELPPVLT FELSRFEFNQ ALGRPEKIHN KLEFPQVLYL
DRYMHRNREI TRIKREEIKR LKDYLTVLQQ RLERYLSYGS GPKRFPLVDV LQYALEFASS
KPVCTSPVDD IDASSPSSGS VPSQTLPSTT DQQGAPSSEL PSTSPASIVA ISSRSVIHKP
FTQSRIPPDL PMHPAPRHIT EEELSVLESC LHRWRTEIEN DTRDLQESIS RIHRTIELMY
SDKSMIQVPY RLHAVLVHEG QANAGHYWAY IFDHRENRWM KYNDIAVTKS SWEELVRDSF
GGYRNASAYC LMYINDKPQF LIQEEFNKET GQALVGIETL PPDLRDFVEE DNQRFEKELE
EWDAQLAQKA LQEKLLASQK LRESESSVTT AQAGEPEYLE QPSRSDFSKH LKEETIRIIT
KASHEHEDKS PETVLQSKPE NTTSQPPSNQ QVVEVAIPHV GKFMIGSKEG GYDDEIMMTP
NMQGIIMAIG KSRNVYDRCG PEAGFFKAIK LEYSRLVKLA QEDTPPETDY RLHHVVVYFI
QNQAPKKIIE KTLLEQFGDR NLSFDERCHN IMKVAQAKIE MIKPEEVNLE EYEEWHQDYR
KFRETTMYLI IGLENFQRES YIDSLLFLIC AYQNNKELLS KGPYRGHDEE LISHYRRECL
LKLNEQAAEL FESGEDREVN NGLIIMNEFI VPFLPLLLVD EMEEKDILAV EDMRNRWCSY
LGQEMESNLQ EKLTDFLPKL LDCSTEIKGF HEPPKLPPYS THELCERFAR IMLSLSRTPA
DGR
//
