ID A0A2Y9NBA8_DELLE Unreviewed; 381 AA.
AC A0A2Y9NBA8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Nucleic acid dioxygenase ALKBH1 {ECO:0000313|RefSeq:XP_022432139.1};
GN Name=ALKBH1 {ECO:0000313|RefSeq:XP_022432139.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022432139.1};
RN [1] {ECO:0000313|RefSeq:XP_022432139.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022432139.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|PIRSR:PIRSR604574-2};
CC Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604574-2};
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DR RefSeq; XP_022432139.1; XM_022576431.1.
DR AlphaFoldDB; A0A2Y9NBA8; -.
DR STRING; 9749.A0A2Y9NBA8; -.
DR KEGG; dle:111176207; -.
DR InParanoid; A0A2Y9NBA8; -.
DR OrthoDB; 47845at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR InterPro; IPR004574; Alkb.
DR InterPro; IPR027450; AlkB-like.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR NCBIfam; TIGR00568; alkb; 1.
DR PANTHER; PTHR16557; ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED; 1.
DR PANTHER; PTHR16557:SF2; NUCLEIC ACID DIOXYGENASE ALKBH1; 1.
DR Pfam; PF13532; 2OG-FeII_Oxy_2; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964,
KW ECO:0000313|RefSeq:XP_022432139.1};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Iron {ECO:0000256|PIRSR:PIRSR604574-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR604574-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 213..347
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT BINDING 231
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
FT BINDING 233
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
FT BINDING 287
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604574-2"
SQ SEQUENCE 381 AA; 42741 MW; 1B9A93D8D802961F CRC64;
MGKMAAAVGS VATLAAEPGE DAFRKLFRFY RQSRPGTVDL GGVIDFSVAH AARGTGPGAH
KVVKSHLNVS SVSDHDAYRA GLQPVSKWRA YGLQGYPGFI FIPNPFLPGY QWHWVKQCLK
LYSQKPNVCN LDKHMTTEET QDLWEQSKEF LRYKEVNKRR PRSLLEKLRW VTLGYHYNWD
NKKYSADHYT PFPSDLAFLS EQVAAACGFQ GFRAEAGILN YYRLDSTLGI HVDRSELDHS
KPLLSFSFGQ SAIFLLGGLK RDEAPTPMFM HSGDIMVMSG FSRLLNHAVP RVLPSLEGES
LPCCLETPLP ADLPRDSVVE PCSVEDWQVC ASYLKTARVN MTVRQVLATG QDFPLELMEE
NKRDATTEGS CHLDDEDSQA K
//
