ID A0A2Y9NDZ3_DELLE Unreviewed; 992 AA.
AC A0A2Y9NDZ3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Echinoderm microtubule-associated protein-like 4 isoform X1 {ECO:0000313|RefSeq:XP_022429682.1};
GN Name=EML4 {ECO:0000313|RefSeq:XP_022429682.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022429682.1};
RN [1] {ECO:0000313|RefSeq:XP_022429682.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022429682.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR RefSeq; XP_022429682.1; XM_022573974.1.
DR AlphaFoldDB; A0A2Y9NDZ3; -.
DR STRING; 9749.A0A2Y9NDZ3; -.
DR KEGG; dle:111174834; -.
DR InParanoid; A0A2Y9NDZ3; -.
DR OrthoDB; 2959353at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR CDD; cd21950; TD_EMAP4; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF11; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 4; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF03451; HELP; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 9.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 239..307
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 516..548
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 599..631
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 728..769
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 841..875
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 107..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 902..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 17..51
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 110..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..943
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 992 AA; 110158 MW; C436D85DF23F57CB CRC64;
MDGFAGSLDD SISAASTSDV QDRLSALELR VQQQEDEITV LKAALADVLR RLTISEDHVA
SVKKSVPSKG QPGIREAISM SCITNGSGAN RKPSHTSSVS IARKETLSSA AKSGTEKKKE
KPQGQREKKE ESHSNDQSPQ IRASPSPQPS SQPLQIHRQT QESKNSTPTK SIKRPPTAEK
SHNSWENSDD SRNKLLRAVS TSKLISKVIK NADKHKDVII NQAKMSTREK NSQEGEYVKM
FMRGRPITMF IPSDVDNYDD IRTELPPEKL KLEWVYGYRG KDCRANVYLL PTGEIVYFIA
SVVVLFNYEE RTQRHYLGHT DCVKCLAIHP DKIRIATGQI AGVDKDGRPL QPHVRVWDSV
SLSTLQIIGL GTFERGVGCL DFSKADSGVH LCVIDDSNEH MLTVWDWQKK SKGAEIKTTN
EVVLAVEFHP TDANTIITCG KSHIFFWTWS GNSLTRKQGV FGKYEKPKFV QCLTFLGNGD
VLTGDSGGVI LIWSKTTVEP TPGKGPKGVY QISKQIKAHD GSVFTLCQMR NGMLLTGGGK
DRKIILWDHD LNPEREIEVP DQYGTIRAVA EGKADQFLVG TSRNFILRGT FNDGFQIEVQ
GHTDELWGLA THPFKDLLLT CAQDRQVCMW NSVEHRLEWT RLVDEPGHCA DFHPSGTVVA
IGTHSGRWFV LDAETRDLVS IHTDGNEQLS VMRYSLDGTF LAVGSHDNFI YLYVVSENGR
KYSRHGKCTG HSSYITHLDW SPDNKYIMSN SGDYEILYWD IPNGCKLIRN RSDCKDIDWT
TYTCVLGFQV FGVWPEGSDG TDINALVRSH NRKVIAVADD FCKVHLFQYP CSKAKAPSHK
YSAHSSHVTN VSFTHNDSHL ISTGGKDMSI IQWKLVEKLS LPQNEVVADT ALTKAPISSI
ESVVQPDAPT PPPSQPLNET AEEESRISSS PTLLENSLEQ TVGPSEDHSE EQSEGGSEDL
GEPVYEEPAH EMSDEQSEGA LPGDQQDPSP LS
//