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Database: UniProt
Entry: A0A2Y9NFL6_DELLE
LinkDB: A0A2Y9NFL6_DELLE
Original site: A0A2Y9NFL6_DELLE 
ID   A0A2Y9NFL6_DELLE        Unreviewed;       681 AA.
AC   A0A2Y9NFL6;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Ectonucleoside triphosphate diphosphohydrolase 8 {ECO:0000256|ARBA:ARBA00039598};
DE            EC=3.6.1.5 {ECO:0000256|ARBA:ARBA00012148};
GN   Name=ENTPD8 {ECO:0000313|RefSeq:XP_022433739.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022433739.1};
RN   [1] {ECO:0000313|RefSeq:XP_022433739.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022433739.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside
CC         5'-phosphate + 2 H(+) + 2 phosphate; Xref=Rhea:RHEA:36795,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:58043, ChEBI:CHEBI:61557; EC=3.6.1.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00000211};
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC       {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR   RefSeq; XP_022433739.1; XM_022578031.2.
DR   AlphaFoldDB; A0A2Y9NFL6; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR   InterPro; IPR000407; GDA1_CD39_NTPase.
DR   PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR   PANTHER; PTHR11782:SF31; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 8; 1.
DR   Pfam; PF01150; GDA1_CD39; 2.
DR   PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Hydrolase {ECO:0000256|RuleBase:RU003833};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|PIRSR:PIRSR600407-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT   REGION          448..495
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        200
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT   BINDING         240..244
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ   SEQUENCE   681 AA;  71978 MW;  212CF57132969DAE CRC64;
     MGLTWRERAF TALLGAAAVS GLTTLILFLV EATNVLLPAD TKFGIVFDAG SSHTSLLVYQ
     WPANKENDTG VVSQALACRA KAPGAPDVAS LQPLPRTSRG LSPVCLKSPS SVSWPGISSY
     ASDPAQAGES LQGCLEEALA LIPKAKHQQT PMFLGATGGM RLLSRKNSSQ AEDVFAAVSQ
     ALSRSPVAFW GAELLAGQDE GALGWVTINY VLGLLVQYSF SGEWIQPLEG TLVGALDMGG
     ASTQITFVPG GPILDTTTQA TFRLYGTEHS VYTHSYLCFG HDQMLNRLLA GLVQSSPSLL
     VRHPCYHSGY RGTLALAPLY GSPCVQAAAP RDLGQNLTVE GTGNPGACVA AIRGLFNFSS
     CDGRGDCAFD RVYQPPVRGQ FYAFSNFYHT FHFLNLTSRP PLATANATIW EFCQRPWKLV
     GGCGPPAPHL GPSSLGCRLH RAGTPSQAVW PGGWGAPGRR LRGTPRRGAS LGGPGGQEAS
     WGSWPPGPPG GGELARAGRP AARLLCLGPV HPHAPARGLR VQPGDLGRHR VPQAGRWHRH
     RLDAGLHAEP DRPDPSRGAR PVAGTELWRL GGRSRLFGAD PHGHSRGHCG AALAPGLGWL
     PPGAGRQRPE LARAFLSPNP KGSPCGLWPH GHMAPFCRWG HSGHGGCAVA PTMAFRCQRP
     SGFPMLHEGW AIATPAALRA V
//
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