ID A0A2Y9NGH9_DELLE Unreviewed; 1439 AA.
AC A0A2Y9NGH9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRG {ECO:0000313|RefSeq:XP_022428388.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022428388.1};
RN [1] {ECO:0000313|RefSeq:XP_022428388.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022428388.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 5 subfamily. {ECO:0000256|ARBA:ARBA00006246}.
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DR RefSeq; XP_022428388.1; XM_022572680.1.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd03122; alpha_CARP_receptor_like; 1.
DR CDD; cd00063; FN3; 1.
DR CDD; cd17670; R-PTP-G-2; 1.
DR CDD; cd17667; R-PTPc-G-1; 1.
DR Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR041887; Alpha_CARP_receptor-type.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF449; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE GAMMA; 1.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_022428388.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 731..756
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 58..321
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000259|PROSITE:PS51144"
FT DOMAIN 349..448
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 842..1113
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1030..1104
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1144..1404
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1321..1395
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 461..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..612
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..701
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1439 AA; 161081 MW; C89F5C4F7058C50C CRC64;
MRRLLEPCWW ILFLKITSSV LHYVVCFPAL TEGYMGALHE NRQGSSVQIR RRKASGDPYW
AYSGAYGPEH WVTSSVSCGG HHQSPIDISD QDARVGEEYQ DLQLDGFDNE SSNKTWMKNT
GKTVAILLKD DYFVSGAGLP GRFKAEKVEF HWGHSNGSAG SEHSINGRRF PVEMQIFFYN
PDDFDSFQTA ISENRIIGAM AIFFQVSPRD NSALDPIIHG LKGVVHHEKE TFLDPFVLRD
LLPASLGSYY RYTGSLTTPP CSEIVEWIVF RTPVPISYHQ LEAFYSIFTT EQQDHVKSVE
YLRNNFRPQQ DLNDRVVSKS AVRDAWNHDM TDFLENPLGT EASKVCSSPP IHMKVQPLNQ
TALQVSWNQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK DSDKDLKATI SPVSPDSLYL
FRVQAVCRND MRSDFSQTML FQANTTRIFQ GTRIVKTGVP TASPASSADM APISSGSSTW
TSSGIPFSFV SMATGMGPSS SGSQATVASV VTSTLLAGLG FSGGGISSFP STVWPTRLPT
AAAASKQAGR PVPATPEALA SPGPDGDSAP TKDGEGAEEG EKDEKSENED GEREHEEEGE
KGSEKKERNG VTHAPQARSG TEPSPAPSAP GRADQDGGRQ TIAGRERDRA AVPTAQPEDA
LDPRPVTLTQ VPPTVTEEHY RENDPKRPET PSKKPMSPGD RFSEDSKFIT VNPEKNTSGM
ISRPSPGRME WIVPLIVVSA LTFVCLILLI AVLVYWRGCN KIKSKGFPRR FHEVPSSGER
GEKGSRKCFQ TAHFYVEDSS SPRVVPNESI PIIPIPDDME AIPVKQFVKH IGELYSNNQH
GFSEDFEEVQ RCTADMNITA EHSNHPDNKH KNRYINILAY DHSRVKLRPL PGKDSKHSDY
INANYVDGYN KAKAYIATQG PLKSTFEDFW RMIWEQNTGI IVMITNLVEK GRRKCDQYWP
TENSEEYGNI IVTLKSTKVH ACYTVRRFSV RNTKVKKGQK GNPKGRQNER VVIQYHYTQW
PDMGVPEYAL PVLTFVRRSS AARTPEMGPV LVHCSAGVGR TGTYIVIDSM LQQIKDKSTV
NVLGFLKHIR TQRNYLVQTE EQYIFIHDAL LEAILGKETE VSSSQLHSYV NSILIPGAGG
KTRLEKQFKL VTQCNAKYVE CFSAQKECNK EKNRNSSVVP SERARVGLAP LPGMKGTDYI
NASYIMGYYR SNEFIITQHP LPHTTKDFWR MIWDHNAQII VMLPDNQSLA EDEFVYWPSR
EESMNCEAFT VTLISKDRLC LSNEEQIIIH DFILEATQDD YVLEVRHFQC PKWPNPDAPI
SSTFELINVI KEEALTRDGP TIVHDEYGAV SAGMLCALTT LSQQLENENA VDVFQVAKMI
NLMRPGVFTD IEQYQFVYKA MLSLVSTKEN GNGPMTVDKN GAVLMADESD PAESMESLV
//
