ID A0A2Y9NGZ1_DELLE Unreviewed; 1455 AA.
AC A0A2Y9NGZ1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=DNA mismatch repair protein Mlh3 isoform X1 {ECO:0000313|RefSeq:XP_022432236.1};
GN Name=MLH3 {ECO:0000313|RefSeq:XP_022432236.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022432236.1};
RN [1] {ECO:0000313|RefSeq:XP_022432236.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022432236.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR RefSeq; XP_022432236.1; XM_022576528.2.
DR STRING; 9749.A0A2Y9NGZ1; -.
DR Ensembl; ENSDLET00000006667; ENSDLEP00000006020; ENSDLEG00000004489.
DR KEGG; dle:111176244; -.
DR InParanoid; A0A2Y9NGZ1; -.
DR OrthoDB; 9570at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005712; C:chiasma; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR GO; GO:0032300; C:mismatch repair complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000795; C:synaptonemal complex; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0019237; F:centromeric DNA binding; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0007144; P:female meiosis I; IEA:Ensembl.
DR GO; GO:0007140; P:male meiotic nuclear division; IEA:Ensembl.
DR GO; GO:0006298; P:mismatch repair; IEA:Ensembl.
DR GO; GO:0008104; P:protein localization; IEA:Ensembl.
DR GO; GO:0007130; P:synaptonemal complex assembly; IEA:Ensembl.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03486; MutL_Trans_MLH3; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF47; DNA MISMATCH REPAIR PROTEIN MLH3; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 211..349
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 1192..1373
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 474..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 865..916
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 929..966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 996..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 865..895
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..966
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1455 AA; 162919 MW; 354ED2A996EB11DB CRC64;
MIKCLSVEVQ ARLRSGLAIC SLGRCVEELA LNSIDAEAKC VAVRVNMETF QVQVIDNGFG
MGSDDIDKVG NRYFTSKCDS VQDLENPRFY GFRGEALASI ADMASAVEIS SKKNKSMKTF
VKLFQNGKVL KACEADLTRP SAGTTVTVYN LFYQLPVRRK CMDPRLEFEK VRQRIEALSL
MHPSISFSLR NDVSGSMVLQ LPRTKDICSR FCQIYGLGKS QKLREIDFKY KEFELSGYIS
SEAHYNKNMQ FLFVNKRLVL RTKLHKLIDF LLRKESIICK PKNGSASRQT NSSPRHRSNP
ELHGIYVINM QCHFCEYDVC LEPAKTLIEF QNWDTVLVCI QEGVKMFLKK EKLFVELSSE
DLKEFSEENE FSLFSATLQK QVSSDEKCDQ VNFQEACNNI LDSCEMFNLQ SKAVKRKAPV
ENISTQNSRD SEAIRKKTND SFLYTYKSDG PTYSKMESSL QNEDSACSES RILEQETAEA
SESGANEKHK KSCLELNSSE NPCGASSEMS AIPFQTLYHF EGSGEGLEIQ KVSTTANGMA
ANILKNNRIQ NQPERFKDAT EMGCQPLPVE TTLSGAHGAQ REEKRKEEPS NCGRINVFSY
GQVKLCSTGF ITHVVQNEQT KSTETEHLFK NYVQPGLVSA KETFGNRTCH SFETPNTKDL
TTTLSKEFAQ LPNKRLCRTN ISYGLENKPI ATYKNFAIFQ ESSKKSYTGC LLPDTSSFTQ
GRHGSDGSKK TGKLICSAKP IAHKKLSLSS QLGSLEKFKR QYGKVKNPLN TEVEENITLE
ITTNLNPQVE PDILWKDKNH LDNSGICKIT TMKHDDSNSS CQPVSHMFYS EKLPFSKEDS
CLEEQMPCLR ESPIPLQELS HFNRKPLDVE KSPESLASKL SRLKGSERET QTMEMTSHSD
ELSQSDSSRK DSDLSSGLTL DSCKLFKNEH KKPESGNIPM SDSVTQGNPF NKDSETYSNN
TTENSVMSET PLVLPYDHST VIGKDSDVLI ASEQQIGSPD SPSRMLVSHG EDSTAGQKGT
CCQSEESIAR TCSENEESNT CSLDWQQHFD VALGRMVYIN KLTGLSTFTA PTEDVRAACT
KDLTTMAVDV LLENGSQYRC HPFRSDLVLP FLPRAREERT VMRQNNRATG DGAVGPESLQ
SLFSEWDNPV FARYPEVAVD VSSGQAESLA VKIHNILYPY RFTKEMIHSM QVLQQVDNKF
IACVMSTKTE ENGEAGGNLL VLVDQHAAHE RIRLEQLTIG SYEKQQPQGS GRKKLLSSTI
SPPLEITVTE EQRRLLSCYH KNLEDLGLEI IFPDTSDSLV LVGKVPLCFV EREASELRRG
RSTVTKSIVE EFIQEQLELL QTTGGIQGTL PLTVQKVLAS QACHGAIKFN DDLSLEESCR
LIEALSWCQL PFQCAHGRPS MLPLADIDHL EQDKQIKPNL AKLRRMAQAW HLFGKAEGCD
TGQSLQASAP PCELP
//
