ID   A0A2Y9NHF8_DELLE        Unreviewed;      1153 AA.
AC   A0A2Y9NHF8;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X4 {ECO:0000313|RefSeq:XP_022428733.1};
GN   Name=CACNA2D2 {ECO:0000313|RefSeq:XP_022428733.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022428733.1};
RN   [1] {ECO:0000313|RefSeq:XP_022428733.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022428733.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta
CC       family. {ECO:0000256|ARBA:ARBA00007060}.
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DR   RefSeq; XP_022428733.1; XM_022573025.2.
DR   AlphaFoldDB; A0A2Y9NHF8; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR   CDD; cd01463; vWA_VGCC_like; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013680; VDCC_a2/dsu.
DR   InterPro; IPR013608; VWA_N.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR   PANTHER; PTHR10166:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-2; 1.
DR   Pfam; PF08473; VGCC_alpha2; 1.
DR   Pfam; PF00092; VWA; 1.
DR   Pfam; PF08399; VWA_N; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022882};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   DOMAIN          294..472
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1153 AA;  130222 MW;  CEC12F18DFB1F4CB CRC64;
     MAVPARTCGA SLPGPARTAL SWPGRGSRPG LSARRPAARP PRPLSLLLPP LLLFPLLAAP
     GASAYSFPQQ HTMQHWARRL EQEIDGVMRI FGGVQQLREI YKDNRNLFEV QENEPQKLVE
     KVAGDIESLL DRKVQALKRL ADAAENFQKA HRWQDNIKEE DIVYYDAKAD AELDDPESED
     VERGSKASTL RLDFVEDSNF KNKVNYSYTA VQIPTDIYKG STVILNELNW TEALENVFIE
     NRRQDPTLLW QVFGSATGVT RYYPATPWRA PKKIDLYDVR RRPWYIQGAS SPKDMVIIVD
     VSGSVSGLTL KLMKTSVCEM LDTLSDDDYV NVASFNEKAQ PVSCFTHLVQ ANVRNKKVFK
     EAVQGMVAKG TTGYKAGFEY AFDQLQNSNI TRANCNKMIM MFTDGGEDRV QDVFEKYNWP
     NRTVRVFTFS VGQHNYDVTP LQWMACTNKG YYFEIPSIGA IRINTQEYLD VLGRPMVLAG
     KEAKQVQWTN VYEDALGLGL VVTGTLPVFN LTQDGPGEKK NQLILGVMGI DVALNDIKRL
     TPNYTLGANG YVFAIDLNGY VLLHPNLKPQ TTNFREPVTL DFLDAELEDE NKEEIRRSMI
     DGNKGHKQIR TLVKSLDERY IDEVMRNYTW VPIRSTNYSL GLVLPPYSTF YLQANLSDQI
     LQVKLPISKL KDFEFLLPSS FESEGHVFIA PREYCKELNA SDNNTEFLKN FIELMEKVTP
     DSKQCNNFLL HNLILDTGIT QQLVERVWRD QDLNTYSLLA VFAATDGGIT RVFPNKAAED
     WTETPEPFNA SFYRRSLDNH GYVFKPPQQD ARLRPLELEN DTVGILVSTA VELSLGGRTL
     RPAVVGVKLD LEAWAEKFKV LASNRTHQDQ PQKCGPNSHC EMDCEVNNED LLCVLIDDGG
     FLVLSNQNHQ WDQVGRFFSE VDANLMLALY NNSFYTRKES YDYQAACAPL PPGNLGAAPR
     GIFVPTIADF LNLAWWTSAA AWSLFQQLLY GLIYHSWFQA DPAEAEGNPE VRESSCVMKQ
     TQYYFGSVNA SYNAIIDCGN CSRLFHAQRL THTNLLFVVA EKPLCSQCEA GRLLQKETHS
     DGPEQCELVQ RPRYRRGPHI CFDYNATEDT SDCGRGASFP PSLGVLVSLQ LLLLLSLPPR
     PQPQVHAHPS RRL
//