ID A0A2Y9NHZ5_DELLE Unreviewed; 403 AA.
AC A0A2Y9NHZ5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2021, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Bone morphogenetic protein 8A {ECO:0000313|RefSeq:XP_022431042.2};
GN Name=BMP8A {ECO:0000313|RefSeq:XP_022431042.2};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022431042.2};
RN [1] {ECO:0000313|RefSeq:XP_022431042.2}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022431042.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_022431042.2; XM_022575334.2.
DR AlphaFoldDB; A0A2Y9NHZ5; -.
DR STRING; 9749.A0A2Y9NHZ5; -.
DR KEGG; dle:111175626; -.
DR InParanoid; A0A2Y9NHZ5; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19398; TGF_beta_BMP8; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF119; BONE MORPHOGENETIC PROTEIN 8A-RELATED; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..403
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030062101"
FT DOMAIN 273..403
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 21..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 44978 MW; 309112812EC5B067 CRC64;
MAARPGPLWL LGLALCALSG GGASGPRPSP GCPQRRLGPR ERRDLQREIL AVLRLPGRPR
PRAPPAAARL PASAPLFMLD MYRAMAGDDE EDGGTPERRL GRADLVMSFV NMAEQDRTLG
HQEPQWKEFR FDLTQIPAGE AVTAAEFRIY KLPSTHLLNW TLHVSMFEVV LEKSNRESDL
FFLDLQTLRS GDEGWLVLDV TAASDRWLLN RNKDLGLRLY VETDDGRSVD PGLAGLLGQQ
APRSKQPFVV TFFRESPGPV RAPRAVRPLK RRLPKRTNEL PPPNKLPGIF DDVHGSHGRQ
VCRRHELYVS FQDLGWLDWV IAPQGYSAYY CEGECSFPLD SCMNATNHAI LQSLVHLMKA
DAVPKACCAP TKLSATSVLY YDSSNNVILR KHRNMVVRAC GCH
//
