ID A0A2Y9NJ41_DELLE Unreviewed; 832 AA.
AC A0A2Y9NJ41;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Very low-density lipoprotein receptor isoform X3 {ECO:0000313|RefSeq:XP_022429298.1};
GN Name=VLDLR {ECO:0000313|RefSeq:XP_022429298.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022429298.1};
RN [1] {ECO:0000313|RefSeq:XP_022429298.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022429298.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_022429298.1; XM_022573590.2.
DR AlphaFoldDB; A0A2Y9NJ41; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00112; LDLa; 7.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 7.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF8; VERY LOW-DENSITY LIPOPROTEIN RECEPTOR; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 7.
DR Pfam; PF00058; Ldl_recept_b; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 7.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 7.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 7.
DR PROSITE; PS51120; LDLRB; 4.
PE 4: Predicted;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipoprotein {ECO:0000313|RefSeq:XP_022429298.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_022429298.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023055}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..832
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015942331"
FT TRANSMEM 757..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 315..354
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 355..390
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 440..483
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 484..526
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 527..570
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 571..615
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 33..45
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 40..58
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 52..67
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 72..84
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 79..97
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 134..149
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 154..166
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 161..179
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 173..188
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 193..205
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 200..218
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 239..251
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 246..264
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 258..273
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 278..290
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 285..303
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 297..312
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 359..369
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 832 AA; 91447 MW; 6341D7C61EE60AF5 CRC64;
MGTSARWALW LLLALCWAPR ESGTTGAGRK AKCEPSQFQC TNGRCITLLW KCDGDEDCAD
GSDEKNCVKK TCAESDFVCN NGQCVPNRWQ CDGDPDCEDG SDESPEQCHM RTCRISEISC
GARSTQCIPV SWRCDGENDC DSGEDEENCG NVTCSPDEFT CSSGRCISRN FVCNGQDDCS
DGSDELDCTP PTCGAHEFQC STSSCIPISW VCDDDADCSD QSDESLEQCG RQPVIHTKCP
ASEIQCGSGE CIHKKWRCDG DPDCKDGSDE VNCPSRTCQP DQFECEDGSC IHRSRQCNGI
RDCVDGSDEV NCKNDVNECL VNNGGCSHIC KDLVIGYECD CAAGFELIDR KTCGDIDECQ
NPGICSQICI NLKGGYKCEC SRGYQMDLAT GVCKAVGKEP SLIFTNRRDI RKIGLERKEY
IQLVEQLRNT VALDADIAAQ KLFWADLSQK AIFSASVDDK VGRHVKMIDN VYNPAAIAVD
WVYKTIYWTD AASKTISVAT LDGTKRKFLF NSDLREPASI AVDPLSGFVY WSDWGEPAKI
EKAGMNGFDR RALVTADIQW PNGITLDLIK GRLYWLDSKL HMLSSVDLNG QDRRVVLKSL
EFLAHPLALT IFEDRVYWID GENEAVYGAN KFTGSELATL VNNLNDAQDI IVYHALVQPS
GKNWCKEDME NGGCEYLCLP APQINDHSPK YTCSCPNGYS LEDNGRECQS TATTVTYSET
KDTNTTEMSP TSGLAPGEIN VTTAVSEVSV PPKGTSAAWA ILPLLLLAMA AVGGYLMWRN
WQHKNMKSMN FDNPVYLKTT EEDLSIDIGR HSASVGHTYP AISVVSTDDD LA
//
