ID A0A2Y9NK40_DELLE Unreviewed; 4884 AA.
AC A0A2Y9NK40;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Probable E3 ubiquitin-protein ligase HERC1 isoform X4 {ECO:0000313|RefSeq:XP_022435434.1};
GN Name=HERC1 {ECO:0000313|RefSeq:XP_022435434.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022435434.1};
RN [1] {ECO:0000313|RefSeq:XP_022435434.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022435434.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022435434.1; XM_022579726.2.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR CDD; cd12881; SPRY_HERC1; 1.
DR CDD; cd14401; UBA_HERC1; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035768; SPRY_HERC1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22872; BTK-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR22872:SF6; E3 UBIQUITIN-PROTEIN LIGASE HERC1-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00415; RCC1; 10.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00400; WD40; 2.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00449; SPRY; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 4.
DR PROSITE; PS50012; RCC1_3; 14.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 372..421
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 422..476
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 477..529
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 530..579
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 581..632
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 633..683
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 684..736
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 2008..2199
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REPEAT 3447..3488
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3645..3676
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3766..3807
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 4020..4068
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4069..4123
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4124..4175
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4176..4227
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4229..4280
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4281..4332
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4333..4384
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 4524..4871
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 125..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1349..1379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1406..1441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1519..1538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2263..2294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2413..2497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2623..2681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2698..2758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2804..2882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3241..3260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2413..2442
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2443..2484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2628..2675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2698..2749
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 4834
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 4884 AA; 534377 MW; E3FB2C7FF51B1423 CRC64;
MATMVPPVKL KWLEHLNSSW ITEDSESIAT REGVAVLYSK LVSNKEVVPL PQQVLCLKGP
QLPDFERESL SSDEQDHYLD ALLSSQLALA KMVCSDSPFA GALRKRLLVL QRVFYALSNK
YHDKGKVKQQ QHSPESSSGS ADVHSVSERP RSSTDALIEM GVRTGLSLLF ALLRQSWMMP
VSGPGLSLCN DVIHTAIEVV SSLPPLSLAN ESKIPPMGLD CLSQVTTFLK GVTIPNSGAD
TLGRRLASEL LLGLAAQRGS LRYLLEWIEM ALGASAVVNS MEKSKLLSSQ EGMISFDCFM
TILMQMRRSL GSSADRSQWR EPPRTSDGLC SLYEAALCLF EEVCRMASDY SRTCASPDSI
QTGDAPIVSE TCEVYVWGSN SSHQLVEGTQ EKILQPKLAP SFSDAQTIEA GQYCTFVISM
DGSVRACGKG SYGRLGLGDS NNQSTLKKLT FEPHRSIKKV SSSKGSDGHT LAFTTEGEVF
SWGDGDYGKL GHGNSSTQKY PKLIQGPLQG KVVVCVSAGY RHSAAVTEDG ELYTWGEGDF
GRLGHGDSNS RNIPTLVKDI SNVGEVSCGS SHTIALSKDG RTVWSFGGGD NGKLGHGDTN
RVYKPKVIEA LQGMFIRKVC AGSQSSLALT STGQVYAWGC GACLGCGSSE ATALRPKLIE
ELAATRVVDI SIGDSHCLAL SHDNEVYAWG NNSMGQCGQG NSTGPITKPK KVSGLDGIAI
QQISAGTSHS LAWTALPRDR QVVAWHRPYC VDLEESTFSH LRSFLERYCD KINSEIPPLP
FPSSREHHSF LKLCLKLLSN HLALALAGGV ATSILGRQGG PLRNLLFRLM DSTVPDEIQE
VVIETLSVGA TMLLPPLRER MELLHSLLPQ GPDRWESLSK GQRMQLDIIL TSLQDHTHVA
SLLGYSAPSD AADLSSVCTG YGNLSDQPYG TQSCHPDTHL AEILMKTLLR NLGFYTDQAF
GELEKNSDKF LLGTSSSENS QPAHLHELLC SLQKQLLAFC HINNISENSS SVALLHKHLQ
LLLPHATDIY SRSANLLKES PWNGSVGEKL RDVIYVSAAG SMLCQIVNSL LLLPVSVARP
LLSYLLDLLP PLDCLNRLLP AATLLEDQEL QWPLHGGPEL IDPAGVPLPQ PAQSWVWLVD
LERTIALLIG QCLGGMLQGS PVSPEEQDTA YWMKTPLFSD GVEMDTPQLD KCMSCLLEVA
LSGNEEQKPF DYKLRPEIAI YVDLALGCSK EPARSLWISM QDYAISKDWD SATLSNESLL
DTVSRFVLAA LLKHTNLLSQ ACGESRYQPG KSLSEVYRCV YKVRSRLLAC KNLELIQTRS
SSRDRWISEN QDSADVDPQE HSFTRTIDEE AEMEEQAERD REEGHPEPGD EEEEREHEVM
TAGNLVFVLH VTEIFQCFLS AREVARSRDR DRMNSGAGSG ARADDPPPQS QQERRVSTDL
PEGQDVYTAA CNSVIHRCAL LILGVSPVID ELQKRREEGQ LQQPSTSASE GGGLMTRSES
LTAESRLIHA SPNYRLIKSR SESDLSQPES DEEGYALSGR RNVDLDLASS HRKRGPMHSQ
LETLSDSWAR LKHNRDWLCS SSNSFESDFD LTKSLGVHTL IENVVSFVSG DVGNAPGFKE
PEESMSTSPQ ASIIAMEQQQ LRAELRLEAL HQILVLLSGM EEKGNISLTG SRSSSGFQSS
TLLTSVRLQF LAGCFGLGTV GHAGAKGESG RLHHYQDGIR AAKRNIQIEI QMAVHKIYQQ
LSATLERALQ ANKHHIEAQQ RLLLVTVFAL SVHYQPVDVS LAISTGLLNV LSQLCGTDTM
LGQPLQLLPK TGVSQLSTAL KVASTRLLQI LAITTGTYAD KLSPKVVQSL LDLLCSQLKN
LLSQAGVLLM ASFGEGEEDE EEKKIDSSGE AEKRDFRVAL RKQRSAELHL GDFLVFLRRV
VSSKAIQSKM ASPKWTEVLL NIASQKCSSG IPLVGNLRTR LLALHVLEAV LPACESGVED
DQMAQVVEHL FSLLSDCMWE TPIAQAKHAI QIKEKEEEIK LQKQGELEEE DENLPIQEVS
FDPEKAQCCI VENGQILTHG SGGKGYGLAS TGVTSGCYQW KFYIVKENRG NEGTCVGVSR
WPVHDFNHRT TSDMWLYRAY SGNLYHNGEQ TLTLSSFTQG DFITCVLDME ARTISFGKNG
EEPKLAFEDV DAAELYPCVM FYSSNPGEKV KICDMQMRGT PRDLLPGDPI CSPVAAVLAE
ATIQLIRILH RTDRWTYCIN KKMMERLHKI KICIKDSGQK LKKSRSVQSR EENEMREEKE
SKEEEKGKHN RHGLADLSEP QLRTLCIEVW PVLAVIGGVD AGLRVGGRCV HKQTGRHATL
LGVVKEGSTS AKVQWDEAEI TISFPTFWSP SDTPLYNLEP CEPLPFDVAR FRGLTASVLL
DLTYLTGIHE DMGKQSTKRH EKKHRHESEE KGDVEQKIES ESALDTRTGL TSDDVKSQGT
TSSKSENEIA SFSLDSTVPG VESQHQITEG KRKNHEHISK NHDIAQSEIR AVQLSYLYLG
AMKSLSALLG CSKYAELLLI PKVLVENGHN SDCASSPVVH EDVEMRAALQ FLMRHMVKRA
VMRSPIKRAL GLADLERAQA MIYKLVVHGL LEDQFGGKIK QEIDQQAEES DQAQQAQTPV
TTSPSASSTT SFMSSSLEDT TTATTPVTDT ETVPASESPG VMPLSLLRQM FSSYPTTTVL
PTRRAQTPPI SSLPTSPSDE VGRRQSLTSP DSQSARPANR TALSDPSSRL STSPPPPAIA
VPLLEMGFSL RQIAKAMEAT GARGEADAQN ITVLAMWMIE HPGHEDEEEP QSGSTADSRH
GATVVGSGGK SNDPCYLQSP GDIPSADAAE MEEGFSESPD NLDHVENAAS GSGPPARGRS
AVTRRHKFDL AARTLLARAA GLYRSVQAHR NQSRREGISL QQDPGALYDF NLDEELEIDL
DDEAMEAMFG QDLTSDNDIL GMWIPEVLDW PTWHVCESED REEVVVCELC ECSVVSFNQH
MKRNHPGCGR SANRQGYRSN GSYVDGWFGG ECGSGNPYYL LCGSCREKYL ALKTKSKATS
SERYKGQAPD LIGKQDSVYE DWDMLDVDEE EKLTGEEEFE LLAGPLGLND RRIVPEPVQF
PDSDPLGASV AMVTATNSME ETLMQIGCHG SVEKSSSGRI TLGEQAAALA NPHDRVVALR
RVTAAAQVLL ARTMVMRALS LLSVSGSSCS LAAGLESLGL TDIRTLVRLM CLAAAGRAGL
STSPSAMAST SERSRGGHSK ANKPISCLAY LSTAVGCLAS NTPSAAKLLV QLCTQNLISA
ATGVNLTTVD DPIQRKFLPS FLRGIAEENK LVTSPNFVVT QALVALLADK GAKLRPNYDK
SEVEKKAGLT AQLYAHPSYD PSAVGPLELA NALAACCLSS RLSSQHRQWA AQQLVRTLAA
HDRDNQTTPQ TLADMGGDLR KCSFIKLEAH QNRVMTCVWC NKKGLLATSG NDGTIRVWNV
TKKQYSLQQT CVFNRLEGDA EESLGSPSDP SFSPVSWSIS GKYLAGALEK MVNIWQVNGG
KGLVDIQPHW VSALAWPEEG PSLAWSGESP ELLLVGRMDG SLGLIEVVDV STMHRRELEH
CYRKDVSVTC IAWFSEDRPF AVGYFDGKLL LGTKEPLEKG GIVLIDAHKD TLISMKWDPT
GHILMTCAKE ENVKLWGPVA GCWRCLHSLC HPSIVNGIAW CSLPGKGSKL HLLMASGCQS
GLVCVWRIPQ DTTQTSVTSS EGWWDQESNC QDGYRKSVGA KCVYQLRGHI TPVRTVAFSS
DGLALVSGGL GGLMNIWSLR DGSVLQTVVI GSGAIQTTVW IPDVGVAACS NRSKDVLVVN
CTAEWAAANH VLATCRTALK QQGVLGLNMA PCMRAFLERL PVMLQEQYAY EKPHVVCGDQ
LVHSPYMQCL ASLAVGLHLD QLLCNPPVPP HHQNCLPDPA SWNPNEWAWL ECFSTTIKAA
EALTNGAQFP ESFTVPDLEP VPEDELVLLM DNSKWINGMD EQIMSWATSR PEDWHLGGKC
DVYLWGAGRH GQLAEAGRNV MVPAAAPSFS QAQQVICGQN CTFVIQANGT VLACGEGSYG
RLGQGNSDDL HVLTVISALQ GFVVTQLVTS CGSDGHSMAL TESGEVFSWG DGDYGKLGHG
NSDRQRRPRQ IEALQGEEVV QMSCGFKHSA VVTSDGKLFT FGNGDYGRLG LGNTSNKKLP
ERVTALEGYQ IGQVACGLNH TLAVSADGSM VWAFGDGDYG KLGLGNSTAK SSPQKVDVLC
GIGIKKVACG TQFSVALTKD GHVYTFGQDR LIGLPEGRAR NHNRPQQIPV LAGVVIEDVA
VGAEHTLALA STGDVYAWGS NSEGQLGLGH TNHVREPTLV TVLQGKNIRQ ISAGRCHSAA
WTAPPVPPRA PGVSVPLQLG LPDAVPPQYG ALREVSIHTA RARLRLLYHF SDLMYSSWRL
LNLSPNNQNS TSHYNAGTWG IVQGQLRPLL APRVYTLPMV RSIGKTMVQG KNYGPQITVK
RISTRGRKCK PIFVQIARQV VKLNASDLRL PSRAWKVKLV GEGADDAGGV FDDTITEMCQ
ELETGIVDLL IPSPNATAEV GYNRDRFLFN PSACLDEHLM QFKFLGILMG VAIRTKKPLD
LHLAPLVWKQ LCCVPLTLED LEEVDLLYVQ TLNSILHIED SGITEESFHE MIPLDSFVGQ
SADGKMVPII PGGNSIPLTF SNRKEYVERA IEYRLHEMDR QVAAVREGMS WIVPVPLLSL
LTAKQLEQMV CGMPEISVEV LKKVVRYREV DEQHQLVQWF WHTLEEFSNE ERVLFMRFVS
GRSRLPANTA DISQRFQIMK VDRPYDSLPT SQTCFFQLRL PPYSSQLVMA ERLRYAINNC
RSIDMDNYML SRNVDNAEGS DTDY
//
