ID A0A2Y9NKM5_DELLE Unreviewed; 594 AA.
AC A0A2Y9NKM5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=SLCO1C1 {ECO:0000313|RefSeq:XP_022433436.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022433436.1};
RN [1] {ECO:0000313|RefSeq:XP_022433436.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022433436.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362056}.
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DR RefSeq; XP_022433436.1; XM_022577728.1.
DR AlphaFoldDB; A0A2Y9NKM5; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF99; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 1C1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 103..133
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 153..177
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 237..255
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 432..459
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 471..494
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 523..546
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 352..407
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
SQ SEQUENCE 594 AA; 65432 MW; EEDDA1A82629367A CRC64;
MGVGTLLIAM PHFFMEQYRY ERYSPFSNST FSISPCFLGS NSPLPISVME KSQSKINNEC
EIDAGSSMWA YVFLGNLLRG IGETPIQPLG IAYLDDFANE DNAAFYIGCV QTVAIIGPIF
GFLLGSLCAK LYVDIGFVNL DHINITPKDP QWVGAWWLGY LIAGSISLLA AVPFWYLPKS
LPRPRSREDS NSSSEKSKFI MDDHTDYQTP LGEKAKIMEM ARDFLPSLKS LFGNPVYFLY
LCASTVQFNS LFGMVTYKPK YIEQQYGQSS SKANFVIGLI NIPAVAFGIF SGGIVMKKFR
ISVCGAAKLY LGSSVLGYLL FLSLFALGCE NSDVAGLTVS YQGTKPVSYH ERALFSDCNS
RCKCSETKWE PMCGANGITY ASACLAGCQT STGSGKTTTF NNCTCVGTAA SKSGNSSGMV
GRCQKDNGCP EMFLYFLVIS VITSYTLSLG GIPGYILLLR CIKPQLKSFA LGIYTLAVRV
LAGIPAPVYF GVLIDTSCLK WGFKRCGSRG SCRLYDSNAF RHMYLGLTMI LGTMSIFLST
AVLFTLKKKY VSKHRSFRTK RERTMESTRI SKENCTTSDH LLQPSYWPGK ETQL
//
