ID A0A2Y9NMI5_DELLE Unreviewed; 2132 AA.
AC A0A2Y9NMI5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Dedicator of cytokinesis protein 9 isoform X7 {ECO:0000313|RefSeq:XP_022432577.1};
GN Name=DOCK9 {ECO:0000313|RefSeq:XP_022432577.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022432577.1};
RN [1] {ECO:0000313|RefSeq:XP_022432577.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022432577.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_022432577.1; XM_022576869.2.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11698; DHR2_DOCK9; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF77; DEDICATOR OF CYTOKINESIS PROTEIN 9; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 174..281
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 640..818
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1629..2094
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1242..1284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2132 AA; 243466 MW; 9F06106A9FF629DB CRC64;
MSQPPLLPSS AETRKFTRAL SKPGTAAELR QSVSEVVRGS VLLAKPKLIE PLDYENVIVQ
KKTQILNDCL REMLLFPYDD FQTAILRRQG RYVCSTIPAN AQQEAQSLFV TECIKTYNSD
WHLVNYKYED YSGEFRQLPN KVAKLDKLPV HVYEVDEEVD KDEDAASLGS QKGGITKHGW
LYKGNMNSAI SVTMRSFKRR FFHLIQLGDG SYNLNFYKDE KISKEPKGSI FLDSCMGVVQ
NNKVRRFAFE LKMQDKSSYL LAADTEAEME EWITTLNKIL QLNFEAAMQE KRNGDSHEDD
EQSKIEGSVS GLDSYLPELA KSTREAEIKL KSESRVKLFY LDPDAQKLDF SSAEPEVKPF
EEKFGKRILV KCNDLSFNLQ CCVAENEEGP TTNVEPFFVT LSLFDIKYNR KISADFHVDL
NHFSVRQMLA TTSPSLMNGG RQSSPALQDI LHEAAMQYPK QGIFSVTCPH PDIFLVARIE
KVLQGSITHG AEPYMKSSDS SKVAQKVLKN AKQACQRLGQ YRMPFAWAAR TLFKDASGNL
DKNARFSALY KQDSNKLSNE DMLKLLADFR KPEKMAKLPV ILGNLDITID SVSSDFPNYV
NSSYIPTKQF ETCTKMPITF EVEEFVPCIP KHTQPYTIYN HHLYVYPKSL KYDSQKSFAK
ARNIAICIEF KDSDEEDSQP LKCIYGRPGG PVFTRSAFAA VLHHHQNPEF YDEIKIELPT
QLHEKHHLLF TFFHVSCDNS SKGSTKKKDV VETQVGYSWL PLLKDGRVVT SEQHIPVSAN
LPSGYLGYQE LGMGRHYGPE IKWVDGSKPL LKVSTHLVST VYTQDQHFHN FFQYCQKTES
GAQALGSELV KYLKSLHAME GHVMIAFLPT ILNQLFRVLT RATQEEVAVN VTRVIIHVVA
QCHEEGLESH LRSYVKYAYK AEPYIASEYK TVHEELTKSM TTILKPSADF LTSNKLLKYS
WFFFEVLIKS MAQHLIENSK VKLLRNQRFP ASYHHAVETV VNMLMPHITQ KFRDNPEASK
NANHSLAVFI KRCFTFMDRG FVFKQINNYI SCFAPGDPKT LFEYKFEFLR VVCNHEHYIP
LNLPMPFGKG RIQRYQDLHL DYALTDEFCR NHFLVGLLLR EVGTALQEFR EVRLIAIGVL
KNLLIKHSFD DRYASRSHQA RIATLYLPLF GLLIENVQRI NVRDVSPFPV NPGSTVKEES
LTLPAVNPIV TPQKSGSTLD ASLHKDLFGA ISGIASPYTN STPNISSVRN ADSRGSLIST
DSGNSLPERN SEKSNSLDKH QQSGTLGNSV VRCDKLDQSE IKSLLMCFLY ILKSMSDDAL
FTYWNKASTS ELMDFFTILE VCLHQFQYMG KRYIARNQEG LGPIVHDRKS QTLPVSRNRT
GMMHARLQQL GSLDNSLTFN HSYGHSDADV LHQSLLEANI ATEVCLTALD TLSLFTLAFK
NQLLADHGHN PLMKKVFDVY LCFLQKHQSE TALKNVFTAL RSLIYKFPST FYERRADMCA
ALCYEVLKCC NSKLSSIRTE ASQLLYFLMR NNFDYTGKKS FVRTHLQVII SVSQLIADVV
GIGGTRFQQS LSIINNCANS DRLIKHTTFS SDVKDLTKRI RTVLMATAQM KEHENDPEML
VDLQYSLAKS YASTPELRKT WLDSMARIHV KNGDLSEAAM CYVHVTALVA EYLTRKEAGL
ALQLEPSFLP SSHSTCQRRR RGGMFRQGCT AFRVITPNID EEASMMEDVG MQDVHFNEDV
LMELLEQCAD GLWKAERYEL IADIYKLIIP IYEKRRDFER LAHLYDTLHR AYSKVTEVMH
SGRRLLGTYF RVGFFGQQYQ FTDSETDVEG FFEDEDGKEY IYKEPKLTPL SEISQRLLKL
YSDKFGSENV KMIQDSGKVN PKDLDSKYAY IQVTHVIPFF DEKELQERKT EFERSHNIRR
FMFEMPFTQT GKRQGGVEEQ CKRRTILTAI HCFPYVKKRI PVMYQHHTDL NPIEVAIDEM
SKKVAELRQL CSSAEVDMIK LQLKLQGSVS VQVNAGPLAY ARAFLDDTNT KRYPDNKVKL
LKEVFRQFVE ACGQALAVNE RLIKEDQLEY QEEMKANYRE MTRELSEIMH EQICPLEEKT
SVLPNSLHIF NAISGTPTST LVHGMTSSSS VV
//
