ID A0A2Y9NMK5_DELLE Unreviewed; 2074 AA.
AC A0A2Y9NMK5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Dedicator of cytokinesis protein 9 isoform X30 {ECO:0000313|RefSeq:XP_022432597.1};
GN Name=DOCK9 {ECO:0000313|RefSeq:XP_022432597.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022432597.1};
RN [1] {ECO:0000313|RefSeq:XP_022432597.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022432597.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022432597.1; XM_022576889.2.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11698; DHR2_DOCK9; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF77; DEDICATOR OF CYTOKINESIS PROTEIN 9; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 185..292
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 651..829
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1609..2036
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1253..1295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2074 AA; 237054 MW; 527272F9E59C8EB2 CRC64;
MGCTTSVILF KGIRTVFERN CAYMCKQQGE NNALEYTAYN WTKEDSELLI SSCLAKPKLI
EPLDYENVIV QKKTQILNDC LREMLLFPYD DFQTAILRRQ GRYVCSTIPA NAQQEAQSLF
VTECIKTYNS DWHLVNYKYE DYSGEFRQLP NKVAKLDKLP VHVYEVDEEV DKDEDAASLG
SQKGGITKHG WLYKGNMNSA ISVTMRSFKR RFFHLIQLGD GSYNLNFYKD EKISKEPKGS
IFLDSCMGVV QNNKVRRFAF ELKMQDKSSY LLAADTEAEM EEWITTLNKI LQLNFEAAMQ
EKRNGDSHED DEQSKIEGSV SGLDSYLPEL AKSTREAEIK LKSESRVKLF YLDPDAQKLD
FSSAEPEVKP FEEKFGKRIL VKCNDLSFNL QCCVAENEEG PTTNVEPFFV TLSLFDIKYN
RKISADFHVD LNHFSVRQML ATTSPSLMNG GRQSSPALQD ILHEAAMQYP KQGIFSVTCP
HPDIFLVARI EKVLQGSITH GAEPYMKSSD SSKVAQKVLK NAKQACQRLG QYRMPFAWAA
RTLFKDASGN LDKNARFSAL YKQDSNKLSN EDMLKLLADF RKPEKMAKLP VILGNLDITI
DSVSSDFPNY VNSSYIPTKQ FETCTKMPIT FEVEEFVPCI PKHTQPYTIY NHHLYVYPKS
LKYDSQKSFA KARNIAICIE FKDSDEEDSQ PLKCIYGRPG GPVFTRSAFA AVLHHHQNPE
FYDEIKIELP TQLHEKHHLL FTFFHVSCDN SSKGSTKKKD VVETQVGYSW LPLLKDGRVV
TSEQHIPVSA NLPSGYLGYQ ELGMGRHYGP EIKWVDGSKP LLKVSTHLVS TVYTQDQHFH
NFFQYCQKTE SGAQALGSEL VKYLKSLHAM EGHVMIAFLP TILNQLFRVL TRATQEEVAV
NVTRVIIHVV AQCHEEGLES HLRSYVKYAY KAEPYIASEY KTVHEELTKS MTTILKPSAD
FLTSNKLLKY SWFFFEVLIK SMAQHLIENS KVKLLRNQRF PASYHHAVET VVNMLMPHIT
QKFRDNPEAS KNANHSLAVF IKRCFTFMDR GFVFKQINNY ISCFAPGDPK TLFEYKFEFL
RVVCNHEHYI PLNLPMPFGK GRIQRYQDLH LDYALTDEFC RNHFLVGLLL REVGTALQEF
REVRLIAIGV LKNLLIKHSF DDRYASRSHQ ARIATLYLPL FGLLIENVQR INVRDVSPFP
VNPGSTVKEE SLTLPAVNPI VTPQKSGSTL DASLHKDLFG AISGIASPYT NSTPNISSVR
NADSRGSLIS TDSGNSLPER NSEKSNSLDK HQQSGTLGNS VVRCDKLDQS EIKSLLMCFL
YILKSMSDDA LFTYWNKAST SELMDFFTIL EVCLHQFQYM GKRYIASVRK ISSVLGISVD
NGYGHSDADV LHQSLLEANI ATEVCLTALD TLSLFTLAFK NQLLADHGHN PLMKKVFDVY
LCFLQKHQSE TALKNVFTAL RSLIYKFPST FYERRADMCA ALCYEVLKCC NSKLSSIRTE
ASQLLYFLMR NNFDYTGKKS FVRTHLQVII SVSQLIADVV GIGGTRFQQS LSIINNCANS
DRLIKHTTFS SDVKDLTKRI RTVLMATAQM KEHENDPEML VDLQYSLAKS YASTPELRKT
WLDSMARIHV KNGDLSEAAM CYVHVTALVA EYLTRKGMFR QGCTAFRVIT PNIDEEASMM
EDVGMQDVHF NEDVLMELLE QCADGLWKAE RYELIADIYK LIIPIYEKRR DFERLAHLYD
TLHRAYSKVT EVMHSGRRLL GTYFRVGFFG QGFFEDEDGK EYIYKEPKLT PLSEISQRLL
KLYSDKFGSE NVKMIQDSGK VNPKDLDSKY AYIQVTHVIP FFDEKELQER KTEFERSHNI
RRFMFEMPFT QTGKRQGGVE EQCKRRTILT AIHCFPYVKK RIPVMYQHHT DLNPIEVAID
EMSKKVAELR QLCSSAEVDM IKLQLKLQGS VSVQVNAGPL AYARAFLDDT NTKRYPDNKV
KLLKEVFRQF VEACGQALAV NERLIKEDQL EYQEEMKANY REMTRELSEI MHEQICPLEE
KTSVLPNSLH IFNAISGTPT STLVHGMTSS SSVV
//
