UniProt: A0A2Y9NMZ4

Database: UniProt
Entry: A0A2Y9NMZ4_DELLE

LinkDB:  A0A2Y9NMZ4_DELLE 
Original site:  A0A2Y9NMZ4_DELLE

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Ontology (7)   
   GO (7)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (31)   
   InterPro (18)   
   Pfam (7)   
   PROSITE (3)   
   SMART (3)   
All databases (39)   

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ID   A0A2Y9NMZ4_DELLE        Unreviewed;      2505 AA.
AC   A0A2Y9NMZ4;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Talin-2 isoform X3 {ECO:0000313|RefSeq:XP_022435390.1};
GN   Name=TLN2 {ECO:0000313|RefSeq:XP_022435390.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022435390.1};
RN   [1] {ECO:0000313|RefSeq:XP_022435390.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022435390.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_022435390.1; XM_022579682.1.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0005925; C:focal adhesion; IEA:InterPro.
DR   GO; GO:0001726; C:ruffle; IEA:InterPro.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd10569; FERM_C_Talin; 1.
DR   CDD; cd17172; FERM_F0_TLN2; 1.
DR   CDD; cd17174; FERM_F1_TLN2; 1.
DR   CDD; cd12150; talin-RS; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 4.
DR   Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.20.1420.10; Talin, central domain; 8.
DR   InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR019747; FERM_CS.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR032425; FERM_f0.
DR   InterPro; IPR018979; FERM_N.
DR   InterPro; IPR035964; I/LWEQ_dom_sf.
DR   InterPro; IPR002558; ILWEQ_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR037438; Talin1/2-RS.
DR   InterPro; IPR015224; Talin_cent.
DR   InterPro; IPR036476; Talin_cent_sf.
DR   InterPro; IPR049108; Talin_R4.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR015009; Vinculin-bd_dom.
DR   PANTHER; PTHR19981; TALIN; 1.
DR   PANTHER; PTHR19981:SF34; TALIN-2; 1.
DR   Pfam; PF16511; FERM_f0; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF09379; FERM_N; 1.
DR   Pfam; PF01608; I_LWEQ; 2.
DR   Pfam; PF09141; Talin_middle; 1.
DR   Pfam; PF21692; Talin_R4; 1.
DR   Pfam; PF08913; VBS; 1.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM00307; ILWEQ; 1.
DR   SMART; SM01244; IRS; 1.
DR   SUPFAM; SSF109880; A middle domain of Talin 1; 1.
DR   SUPFAM; SSF47220; alpha-catenin/vinculin-like; 5.
DR   SUPFAM; SSF109885; I/LWEQ domain; 4.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS00661; FERM_2; 1.
DR   PROSITE; PS50057; FERM_3; 1.
DR   PROSITE; PS50945; I_LWEQ; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT   DOMAIN          88..406
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
FT   DOMAIN          2257..2496
FT                   /note="I/LWEQ"
FT                   /evidence="ECO:0000259|PROSITE:PS50945"
FT   COILED          2464..2491
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   2505 AA;  267447 MW;  DA8F08A2BE86E6FB CRC64;
     MVALSLKICV RHCNVVKTMQ FEPSTAVYDA CRVIRERVPE AQTGQASDYG LFLSDEDPRK
     GIWLEAGRTL DYYMLRNGDI LEYKKKQRPQ KIRMLDGSVK TVMVDDSKTV GELLVTICSR
     IGITNYEEYS LIQETIEEKK EEGTGTLKKD RTLLRDERKM EKLKAKLHTD DDLNWLDHSR
     TFREQGVDEN ETLLLRRKFF YSDQNVDSRD PVQLNLLYVQ ARDDILNGSH PVSFEKACEF
     GGFQAQIQFG PHVEHKHKPG FLDLKEFLPK EYIKQRGAEK RIFQEHKNCG EMNEIEAKVK
     YVKLARSLRT YGVSFFLVKE KMKGKNKLVP RLLGITKDSV MRVDEKTKEV LQEWPLTTVK
     RWAASPKSFT LDFGEYQESY YSVQTTEGEQ ISQLIAGYID IILKKKQSKD RFGLEGDEES
     TMLEESVSPK KSTILQQQFN RTGKVEHGSV ALPAVMRSGS SGPETFNVGS MPSPQQQVMV
     GQMHRGHMPP LTSAQQALMG TINTSMHAVQ QAQDDLSELD SLPPLGQDMA SRVWVQNKVD
     ESKHEIHSQV DAITAGTASV VNLTAGDPAD TDYTAVGCAI TTISSNLTEM SKGVKLLAAL
     MDDEVGSGED LLRAARTLAG AVSDLLKAVQ PTSGEPRQTV LTAAGSIGQA SGDLLRQIGE
     NETDERFQDV LMSLAKAVAN AAAMLVLKAK NVAQVAEDTV LQNRVIAAAT QCALSTSQLV
     ACAKVVSPTI SSPVCQEQLI EAGKLVDRSV ENCVHACQAA TDDTELLKQV SAAASVVSQA
     LHDLLQHVRQ FASRGEPIGR YDQATDTIMC VTESIFSSMG DAGEMVRQAR VLAQATSDLV
     NAMRSDAEAE IDMENSKKLL AAAKLLADST ARMVEAAKGA AANPENEDQQ QRLREAAEGL
     RVATNAAAQN AIKKKIVNRL EVAAKQAAAA ATQTIAASQN AAVSNKNPAA QQQLVQSCKA
     VADHIPQLVQ GVRGSQAQAE DLSAQLALII SSQNFLQPGS KMVSSAKAAV PTVSDQAAAM
     QLSQCAKNLA TSLAELRTAS QKAHEACGPM EIDSALSTVQ TLKSELQDAK MAAVESQLKP
     LPGETLEKCA QDLGSTSKAV GSSMAQLLTC AAQGNEHYTG ETHTLRDALR PGVAARETAQ
     ALKTLAQAAR GVAASTSDPA AVHAMLDSAR DVMEGSAMLI QEAKQALIAP GDAESQQRLA
     QVAKAVSHSL NNCVNCLPGQ KDVDVALKSI GESSKKLLVD SLPPSTKPFQ EAQSELNQAA
     ADLNQSAGEV VHATRGQSGE LAAASGKFSD DFDEFLDAGI EMAGQAQTKE DQIQVIGNLK
     NISMASSKLL LAAKSLSVDP GAPNAKNLLA AAARAVTESI NQLISLCTQQ APGQKECDNA
     LRELETVKGM LDNPNEPVSD LSYFDCIESV MENSKVLGES MAGISQNAKT GDLPAFGECV
     GIASKALCGL TEAAAQAAYL VGISDPNSQA GHQGLVDPIQ FARANQAIQM ACQNLVDPGS
     SPSQVLSAAT IVAKHTSALC NACRIASSKT GNPVAKRHFV QSAKEVANST ANLVKTIKAL
     DGDFSEDNRN KCRIATAPLI EAVENLTAFA SNPEFVSIPA QISSEGSQAQ EPILVSAKTM
     LESSSYLIRT ARSLAINPKD PPTWSVLAGH SHTVSDSIKS LITSIRDKAP GQRECDYSID
     SINRCIRDIE QASLAAVSQS LATRDDISVE ALQEQLTSVV QEIGHLIDPI ATAARGEAAQ
     LGHKVTQLAS YFEPLILAAV GVASKILDHQ QQMTVLDQTK TLAESALQML YAAKEGGGNP
     KAQHTHDAIT EAAQLMKEAV DDIMVTLNEA ASEVGLVGGM VDAIAEAMSK LDEGTPPEPK
     GTFVDYQTTV VKYSKAIAVT AQEMMTKSVT NPEELGGLAS QMTSDYGHLA LQGQMAAATA
     EPEEVSLVLS ALQAGNKGTQ ACITAATAVS GIIADLDTTI MFATAGTLNA ENNETFADHR
     ENILKTAKAL VEDTKLLVSG AASTPDKLAQ AAQSSAATIT QLAEVVKLGA ASLGSDDPET
     QVVLINAIKD VAKALSDLIG ATKGAASKPA DDPSMYQLKG AAKVMVTNVT SLLKTVKAVE
     DEATRGTRAL EATIEYMKQE LTVFQSKEVP EKTSSPEESI RMTKGITMAT AKAVAAGNSC
     RQEDVIATAN LSRKAVSDML TACKQASYHP DVSDEVRTRA LRYGTECTLG YLDLLEHVLV
     ILQKPTPELK HQLAAFSKRV AGAVTELIQA AEAMKGTEWV DPEDPTVIAE TELLGAAASI
     EAAAKKLEQL KPRAKPKQAD ETLDFEEQIL EAAKSIAAAT SALVKSASAA QRELVAQGKV
     GSIPANAADD GQWSQGLISA ARMVAAATSS LCEAANASVQ GHASEEKLIS SAKQVAASTA
     QLLVACKVKA DQDSEAMRRL QAAGNAVKRA SDNLVRAAQK AAFGKAGDDD VVVKTKFVGG
     IAQIIAAQEE MLKKERELEE ARKKLAQIRQ QQYKFLPTEL REDEG
//

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