UniProt: A0A2Y9NN36

Database: UniProt
Entry: A0A2Y9NN36_DELLE

LinkDB:  A0A2Y9NN36_DELLE 
Original site:  A0A2Y9NN36_DELLE

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Ontology (5)   
   GO (5)   
Gene (3)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (20)   
   InterPro (9)   
   Pfam (4)   
   PROSITE (3)   
   SMART (4)   
All databases (29)   

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ID   A0A2Y9NN36_DELLE        Unreviewed;      2461 AA.
AC   A0A2Y9NN36;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Spectrin alpha chain, non-erythrocytic 1 isoform X4 {ECO:0000313|RefSeq:XP_022434271.1};
GN   Name=SPTAN1 {ECO:0000313|RefSeq:XP_022434271.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022434271.1};
RN   [1] {ECO:0000313|RefSeq:XP_022434271.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022434271.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC       {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- SIMILARITY: Belongs to the spectrin family.
CC       {ECO:0000256|ARBA:ARBA00006826}.
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DR   RefSeq; XP_022434271.1; XM_022578563.2.
DR   Ensembl; ENSDLET00000016812; ENSDLEP00000015224; ENSDLEG00000010997.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd11808; SH3_Alpha_Spectrin; 1.
DR   CDD; cd00176; SPEC; 12.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.58.60; -; 20.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR035825; Alpha_Spectrin_SH3.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014837; EF-hand_Ca_insen.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   PANTHER; PTHR11915:SF435; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 5; 1.
DR   PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08726; EFhand_Ca_insen; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   Pfam; PF00435; Spectrin; 20.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   PRINTS; PR01887; SPECTRNALPHA.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM01184; efhand_Ca_insen; 1.
DR   SMART; SM00326; SH3; 1.
DR   SMART; SM00150; SPEC; 20.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 17.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          967..1026
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          2312..2347
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          2355..2390
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   COILED          290..324
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          386..416
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          858..889
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1126..1160
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1682..1716
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2161..2193
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   2461 AA;  283434 MW;  D8DA69B2247D66BF CRC64;
     MDPSGVKVLE TAEDIQERRQ QVLDRYHRFK ELSTLRRQKL EDSYRFQFFQ RDAEELEKWI
     QEKLQIASDE NYKDPTNLQG KLQKHQAFEA EVQANSGAIV KLDETGNLMI SEGHFASETI
     RTRLMELHRQ WELLLEKMRE KGIKLLQAQK LVQFLRECED VMDWINDKEA IVTSEELGQD
     LEHVEVLQKK FEEFQTDMAA HEERVNEVNQ FAAKLIQEQH PEEELIKTKQ DEVNAAWQRL
     KGLALQRQGK LFGAAEVQRF NRDVDETISW IKEKEQLMAS DDFGRDLASV QALLRKHEGL
     ERDLAALEDK VKALCAEADR LQQSHPLSAT QIQVKREELI TNWEQIRTLA AERHARLNDS
     YRLQRFLADF RDLTSWVTEM KALINADELA NDVAGAEALL DRHQEHKGEI DAHEDSFKSA
     DESGQALLAA GHYASDEVRE KLTILSEERA ALLELWELRR QQYEQCMDLQ LFYRDTEQVD
     NWMSKQEAFL LNEDLGDSLD SVEALLKKHE DFEKSLSAQE EKITALDEFA TKLIQNNHYA
     MEDVATRRDA LLSRRNALHE RAMYRRAQLA DSFHLQQFFR DSDELKSWVN EKMKTATDEA
     YKDPSNLQGK VQKHQAFEAE LSANQSRIDA LEKAGQKLID VNHYAKDEVA ARMNEVISLW
     KKLLEATELK GIKLREANQQ QQFNRNVEDI ELWLYEVEGH LASDDYGKDL TNVQNLQKKH
     ALLEADVAAH QDRIDGITIQ ARQFQDAGHF DAENIKKKQE ALVARYEALK EPMIARKQKL
     ADSLRLQQLF RDVEDEETWI REKEPIAAST NRGKDLIGVQ NLLKKHQALQ AEIAGHEPRI
     KAVTQKGNAM VDEGHFAAED VKAKLHELNQ KWESLKSKAS QRRQDLEDSL QAQQYFADAN
     EAESWMREKE PIVGSTDYGK DEDSAEALLK KHEALMSDLS AYGSSIQALR EQAQSCRQQV
     APMDDETGKE LVLALYDYQE KSPREVTMKK GDILTLLNST NKDWWKVEVN DRQGFVPAAY
     VKKLDPAQSA SRENLLEEQG SIALRQEQID NQTRVTKEAG SVSLRMKQVE ELYHSLLELG
     EKRKGMLEKS CKKFMLFREA NELQQWINEK EAALTSEEVG ADLEQVEVLQ KKFDDFQKDL
     KANESRLKDI NKVAEDLESE GLMAEEVQAV QQQEVYGAMP RDETDSKTAS PWKELNERWR
     SLQQLAEERS QILGSAHEVQ RFHRDADETK EWIEEKNQAL NTDNYGHDLA SVQALQRKHE
     GFERDLAALG DKVNSLGETA ERLIQSHPES AEDLQEKCTE LNQAWSSLGK RADQRKAKLG
     DSHDLQRFLS DFRDLMSWIN GIRGLVSSDE LAKDVTGAEA LLERHQEHRT EIDARAGTFQ
     AFEQFGQQLL AHGHYASPEI EEKLHILDQE RADLEKAWVQ RRMMLDQCLE LQLFHRDCEQ
     AESWMAAREA FLSTEDKGDS LDSVEALIKK HEDFDKAINV QEEKIAALQS FADQLIAGGH
     YAKGDVSSRR NEVLDRWRRL KAQMIEKRSK LGESQTLQQF SRDVDEIEAW ISEKLQTASD
     ESYKDPTNIQ LSKLLSKHQK HQAFEAELHA NADRIRGVID MGNSLIDRGA CAGSEDAVKA
     RLAALADQWQ FLVQKSAEKS QKLKEANKQQ NFNTGIKDFD FWLSEVEALL ASEDYGKDLA
     SVNNLLKKHQ LLEADISAHE DRLKDLNSQA DSLMTSSAFD TSQVKDKRDT INGRFQKIKS
     MAASRRARLN ESHRLHQFFR DMDDEESWIK EKKLLVSSED YGRDLTGVQN LRKKHKRLEA
     ELAAHEPAIQ GVRDTGKKLS DDNTIGKEEI EQRLAQFVEH WRELKRLAAA RGQRLEESLE
     YQQFVANVEE EEAWINEKMT LVASEDYGDT LAAIQGLLKK HEAFETDFTV HKDRVNDVCT
     NGQDLIKKNN HHEENISSKM KGLNGKVSDL EKAAAQRKAK LDENSAFLQF NWKADVVESW
     IGEKESSLKT DDHGRDLSSV QTLLTKQETF DAGLQAFQQE GIANITALKD QLLAAKHIQS
     KAIEARHAAL MKRWSQLLAN SATRKKKLLE AQSHFRKVED LFLTFAKKAS AFNSWFENAE
     EDLTDPVRCN SLEEIKALRE AHDAFRSSLS SAQADFNQLA ELDRQIKSFR VASNPYTWFT
     MEALEETWRN LQKIIKEREL ELQKEQRRQE ENDKLRQEFA QHANAFHQWI QETRTYLLDG
     SCMVEESGTL ESQLEATKRK HQEIRAMRSQ LKKIEDLGAA MEEALILDNK YTEHSTVGLA
     QQWDQLDQLG MRMQHNLEQQ IQARNTTGVT EEALKEFSMM FKHFDKDKSG RLNHQEFKSC
     LRSLGYDLPM VEEGEPDPEF EAILDTVDPN RDGHVSLQEY MAFMISRETE NVKSSEEIES
     AFRALSSEGK PYVTKEELYQ NLTREQADYC VSHMKPYVDG KGRELPTAFD YVEFTRSLFV
     N
//

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