ID A0A2Y9NPR7_DELLE Unreviewed; 655 AA.
AC A0A2Y9NPR7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=fatty acid amide hydrolase {ECO:0000256|ARBA:ARBA00012112};
DE EC=3.5.1.99 {ECO:0000256|ARBA:ARBA00012112};
GN Name=FAAH {ECO:0000313|RefSeq:XP_022431318.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022431318.1};
RN [1] {ECO:0000313|RefSeq:XP_022431318.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022431318.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+);
CC Xref=Rhea:RHEA:26506, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:30823, ChEBI:CHEBI:116314; EC=3.5.1.99;
CC Evidence={ECO:0000256|ARBA:ARBA00000208};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:26507;
CC Evidence={ECO:0000256|ARBA:ARBA00000208};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine =
CC (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine;
CC Xref=Rhea:RHEA:26136, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:32395, ChEBI:CHEBI:57603; EC=3.5.1.99;
CC Evidence={ECO:0000256|ARBA:ARBA00000231};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:26137;
CC Evidence={ECO:0000256|ARBA:ARBA00000231};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N-(9Z-octadecenoyl) ethanolamine = (9Z)-octadecenoate +
CC ethanolamine; Xref=Rhea:RHEA:45060, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:30823, ChEBI:CHEBI:57603, ChEBI:CHEBI:71466;
CC Evidence={ECO:0000256|ARBA:ARBA00000890};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45061;
CC Evidence={ECO:0000256|ARBA:ARBA00000890};
CC -!- SIMILARITY: Belongs to the amidase family.
CC {ECO:0000256|ARBA:ARBA00009199}.
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DR RefSeq; XP_022431318.1; XM_022575610.2.
DR AlphaFoldDB; A0A2Y9NPR7; -.
DR STRING; 9749.A0A2Y9NPR7; -.
DR KEGG; dle:111175768; -.
DR InParanoid; A0A2Y9NPR7; -.
DR OrthoDB; 731186at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0017064; F:fatty acid amide hydrolase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.90.1300.10; Amidase signature (AS) domain; 2.
DR InterPro; IPR020556; Amidase_CS.
DR InterPro; IPR023631; Amidase_dom.
DR InterPro; IPR036928; AS_sf.
DR PANTHER; PTHR45847; FATTY ACID AMIDE HYDROLASE; 1.
DR PANTHER; PTHR45847:SF3; FATTY-ACID AMIDE HYDROLASE 1; 1.
DR Pfam; PF01425; Amidase; 2.
DR SUPFAM; SSF75304; Amidase signature (AS) enzymes; 2.
DR PROSITE; PS00571; AMIDASES; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801,
KW ECO:0000313|RefSeq:XP_022431318.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 96..269
FT /note="Amidase"
FT /evidence="ECO:0000259|Pfam:PF01425"
FT DOMAIN 348..638
FT /note="Amidase"
FT /evidence="ECO:0000259|Pfam:PF01425"
SQ SEQUENCE 655 AA; 70274 MW; 93C663FA37456598 CRC64;
MVLEELWAAL SGSSGATLAC CLVAAALALR WSSHRTARGA AARARQRQQA ALETMDKAAQ
RFRLQNPDLD SEALLALPLP QLVQKLHSGE LSPEAVLFTY LGKAWEVNKG TNCVTAYLAD
CEAQLCQAPR QGLLYGVPVS LKECFSYKGQ DSTLGLSLHE GAPAERDSVV VQVLKRQGAL
PFVYTNVPQS MFSYDCGNPL FGQTVNPWKS SKSPGGSSGG EGALIAAGGS PLGLGTDIGG
SIRFPSAFCG ICGLKPTGNR ISKSGLKGCV YGQVAGEVCG SLYALEEGGL PDLPLPLPLL
GAVLGPQATL GLSSCALSLF TLRATAQSLL GPGPRAPWGW VISLSSPPCP TVQLSVGPMA
RDVESLALCL RALLCEDMFH LDPSVPPLPF REEVYTSSQP LRVGYYETDN YTMPTPAMTR
ALLETKKRLE AAGHTLVPFL PSNIPHALET LSTGGLFSDG GKSFLQNFKG DFVDPCLGNL
ISALRLPSWL KGLLAFMLRP LLPRLSAFLN SMKSRSAGKL WELHHEIEVY RHSVIAQWRA
VELDVLLTPM LGPALDLNGP GKATGAISYT LLYNCLDFPA GVVPVTTVTA EDEAQLEHYK
GCFGDIWDKA LQKAVKKSVG LPVAVQCVAL PWQEELCLRF MREVERLMTP ERQPC
//
