ID A0A2Y9NQ21_DELLE Unreviewed; 2624 AA.
AC A0A2Y9NQ21;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Dystonin isoform X35 {ECO:0000313|RefSeq:XP_022437234.1};
GN Name=DST {ECO:0000313|RefSeq:XP_022437234.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022437234.1};
RN [1] {ECO:0000313|RefSeq:XP_022437234.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022437234.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, desmosome
CC {ECO:0000256|ARBA:ARBA00004568}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004236}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR RefSeq; XP_022437234.1; XM_022581526.2.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 3.90.1290.10; Plakin repeat; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169:SF26; DESMOPLAKIN; 1.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR Pfam; PF00681; Plectin; 4.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF00435; Spectrin; 1.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00250; PLEC; 11.
DR SMART; SM00150; SPEC; 3.
DR SUPFAM; SSF75399; Plakin repeat; 2.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 561..618
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1871..1926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 344..371
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 408..442
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 882..916
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1133..1475
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1515..1850
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1873..1897
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2624 AA; 302762 MW; F10E945E0055F7C7 CRC64;
MHSSSYSYRS SDSVFSNTTS TRTSLDSNEN FLSVHCGPTL INSCISFGNE SFDGHRLDML
QQIASRVQRG SVICEDKLML ARNAFQSDSK RLESGVQFQN EAEIAGYVLE CENLLRQHVI
DVQILIDGKY YQADQLVQRV AKLRDDILAL RNECSSVYSK GRVLTAEQTK LMISGISQSL
NSGFAQTLNA SLNSGLTQGL TPSLTPSSVT SGLSSGLTSR LTPSVTPAYT PGFPSGLVPN
FSSGVETNSL QTLKLMQIRK PLLKSSLLDQ NLTEEEINMK FVQDLLNWVD EMQVQLDRTE
WGSDLPSVES HLENHKNVHQ AIEEFESSLK EAKISEIQMT APLKLTYAEK LHRLENQYAK
LLNTSRNQER HLDTLHSFVT RATNELIWLN EKEEGEVAYD WSERNTNIAR KKDYHAELMR
ELDQKEENIK SVQEIAEQLL LENHPARLTI EAYRAAMQTQ WSWILQLCQC VEKHIKDNSA
YFEFFNDAKE ATDYLRNLKD AIQRKYSCDR SSSIHKLEDL VQESMEEKEE LLQYKSTVAS
LMGRAKTIIQ LKPRNPDCPL KTSIPIKAIC DYRQIEITIF KDDECVLANN SHRAKWKVIS
PTGNEAMVPS VCFSVPPPNK EAVDFANRIE QQYQNVLTLW HESHINMKSV VSWHYLINEI
DRIRASNVAS IKTMLPGEHQ QVLSNLQSRF EDFLEDSQES QIFSGSDITQ LEKEVNVCKQ
YYQELLKSAE REEQEESAYN LYISEVRNLR LRLESCEDRL IRQIRTPLER DDLHESVFRI
SEQEKLKKEL ERLKGDLATI TSKCDDFFSQ AAASSTAPTL RSELSVVVQS MNHVYSMSST
YIEKLKIVNL VLKNTHAAEA LVKFYETKLC EEEAVIADKN NIENLMSTLK QWRSEVDEKR
EVFHALEDEL QRAKTISDEM FKTYKERDLD FDWHKEKADQ LVERWQNVHA QIDNRLRDLE
VIGKSLKYYK DTYHPLDDWI QQVETTQRKI QENQPENSKT LATQLNQQKM LVSEIEMKQS
KMDECQKYAE QYSTAVKDYE LQTMTYRAMV DSQQKSPVKR RRMQSSADLV IQEFMDLRTR
YTALVTLMTQ YIKFVGDSLK RLEEEEMKRC QEASEHGVYS DLLQRQEATM LENRKLTGKI
TELERMLAEL EKQKCRVEEE LPKVREAAEN ELRKQQRDAA DITLQKMRAE GEAQRYRREL
EAVEGENEAA QRELERVRRL TAEAEAQREA VQRNLRGFRK QLEEHTATRR ALENHLKRKD
SSLHEVEQQK DKLMEELRRK KDHEEELLKL VEQMEKDLTF QKQVAEKQLK EKQKIESEAR
RKIIEMQCSY KENPLPACMS TQAEELKQQV DELTVADRKT EKDMRELKYE LSALQLKKTS
SEEKARLLKE KLGETSNALR SLKLELERKD QVEEGFSRQL RELDRQLSQT TGKAEEVRQE
ANDLKRIKHN YELELESLQE EKGKLQREVD RITRTQAVTK RSIQHLNSQV TSLQDDKDFS
GERARSCQRK SDHLKEQFEK SHVQLLQNIQ AEKENNEKIQ KLKEELERSN DCADTLKHKV
DELTRQNNET KLMMERIQAE SANVVLEKQA IQQRCEALKI QADGFKDQLC ATNKHLHKQT
KTEQDFQRRI KCLEEDLAQS QHLVSEFKQK CDQQDLIIQN TEKEVQSLSA ELSASKEEKR
LGEQAVQMQW AQVQDLNDRL KKVQDELHLK ILEEQVTHRK MVLFQEESEK FKRSAEEFRK
KMEKLMDSKV ITEHDISGIQ LDFVSLQREK FRAQENARLC ETNIRELERQ LQQYREQMHR
GQNGEAHHYQ KCRKLTDELV AQKREVENLK QKMDQQIKEQ EHQLVVLQCE IQKKNPAFKP
HLEMAVKEYQ RPGDFSSSPS MARSPLQRWT QEPQLSEEGW QHRGAEQMQK EGQGGPSGAP
VEKEKSQQCY SEYFSQTSTE LQITFDEMNP VARLSEIEKL RNQGLYNSRH AVRCQDDKCE
IDLVTLLAPL EIAKNKQYAM HTEVTALKQE KSPVPSADEW LLEGCRALGG LKRDFLKKGS
EPETFQNFGG DHACSVRDDE FQFQGLRHTV TARQLVEAKL LDMKTVEQLR LGLKTVEEVQ
KTLSKFLTKA TSIAGLYLES TTEKISFSSA AKKIIIDKMM TLAFLEAQAA TGFIIDPLSG
KTYSVEDAIV KGVVDPEFKI RLLEAEKAAL GYPCSSKTLS VFQAMENRML DRQRGKHMLE
VQIASGGVID PVRGIRVPPE VALQQGLLNN AILQFLHEPS SNTRAFPNPN NKRTLYYSEL
LRMCVFDVDG QCFLFPFGER NISNLNVAKT HRIAVVDTKT GAELTAYEAF QRNLIEKSTY
LELSGQQYQW KEATFFESYG RPCRILTDSK TGLQFSISEA IEQGTIDKAS IKKYQEGFLT
LTELADSLLS RLVPKKDSRS PVAGYWLTSS GERISVLKAT RRNLVDRITA LRCLEAQVST
GGIIDPLTGK RYRVAEALHR GLVDERFAQQ LRQCELVVTG ISHPISNKVM SVVEAVSANI
ISKDMGIRCL EFQYLTGGLI EPQTQARLSI EEALQVGIID VFIATKLKDQ KSYVRNILCP
QTKRKLTYKE ALEKADFDFH TGLKLLEVSE PLMTGISSLY YSSQ
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