ID A0A2Y9NQC1_DELLE Unreviewed; 607 AA.
AC A0A2Y9NQC1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform X1 {ECO:0000313|RefSeq:XP_022433537.1};
GN Name=ARNTL2 {ECO:0000313|RefSeq:XP_022433537.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022433537.1};
RN [1] {ECO:0000313|RefSeq:XP_022433537.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022433537.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022433537.1; XM_022577829.1.
DR AlphaFoldDB; A0A2Y9NQC1; -.
DR STRING; 9749.A0A2Y9NQC1; -.
DR KEGG; dle:111176870; -.
DR InParanoid; A0A2Y9NQC1; -.
DR OrthoDB; 2872674at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd11469; bHLH-PAS_ARNTL2_PASD9; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR23042:SF48; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR23042; CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Receptor {ECO:0000313|RefSeq:XP_022433537.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 78..131
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 149..214
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 349..398
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 59..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 607 AA; 67275 MW; E8E986A497467A5F CRC64;
MPLSVCLLTG PGAFPCGPMW PGMPPPPGNR KVLIEGNQCI AAMVSSHLSP WTKPATIGSF
SPHVTEFPRK RKGSDSDPSQ EAHSQTEKRR RDKMNNLIEK LSAMIPQCNP MARKLDKLTV
LRMAVEHLRS LKGMTSSYAG NNYRPSFIQD NELRHLILKT AEGFLFVVGC ERGKILFISK
SVSKILNYDQ ASLTGQSLFD FLHPKDVAEV KEQLSSSDIS PREKLIDAET GLQAHGNFHT
GRSCVYSGSR RSFFCRIKSC KISVKEEHEC LLNSKKKDHR KFCTIHCTGY LRNWPPNIVG
MEEETDNKKD SSNFTCLVAI GRLHPYIVPQ NSGEIKVKPT EFITRFAVNG QFVYVDQRAT
AILGYLPQEL LGTSCYEYFH QDDHSNLTDK HKAVLQSKEK IFTDSYKFRA KDGSFVTLKS
QWFSFTNPWT KELEYIVSVN TLVLGHSDTG ETSLLPCSSQ SSEGSSRQSC ISVPGMSTGT
VLGAGSIGTD IASELLDLQR LQSSSSLDDS SPTDLLKDTH TINCRNMSNK ELTTLSPSEI
GELQATKQNQ SAVAPHRHEP LLGEGAQLDF DALCDNDDTA MAAFMNYLEA EGGLGDPGDF
SDIHWAL
//
