ID A0A2Y9NRQ1_DELLE Unreviewed; 710 AA.
AC A0A2Y9NRQ1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Zinc finger CCCH domain-containing protein 14 {ECO:0000256|ARBA:ARBA00015071, ECO:0000256|RuleBase:RU369058};
GN Name=ZC3H14 {ECO:0000313|RefSeq:XP_022432043.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022432043.1};
RN [1] {ECO:0000313|RefSeq:XP_022432043.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022432043.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in poly(A) tail length control in neuronal cells.
CC Binds the polyadenosine RNA oligonucleotides.
CC {ECO:0000256|ARBA:ARBA00003177, ECO:0000256|RuleBase:RU369058}.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|RuleBase:RU369058}.
CC Note=Colocalizes with poly(A) RNA in nuclear speckles.
CC {ECO:0000256|RuleBase:RU369058}.
CC -!- SIMILARITY: Belongs to the ZC3H14 family.
CC {ECO:0000256|ARBA:ARBA00008423, ECO:0000256|RuleBase:RU369058}.
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DR RefSeq; XP_022432043.1; XM_022576335.1.
DR AlphaFoldDB; A0A2Y9NRQ1; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008143; F:poly(A) binding; IEA:UniProtKB-UniRule.
DR GO; GO:1900364; P:negative regulation of mRNA polyadenylation; IEA:InterPro.
DR GO; GO:0043488; P:regulation of mRNA stability; IEA:UniProtKB-UniRule.
DR Gene3D; 4.10.1000.30; -; 1.
DR Gene3D; 4.10.1000.40; -; 1.
DR Gene3D; 1.20.1390.10; PWI domain; 1.
DR InterPro; IPR040366; Nab2/ZC3H14.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR14738; ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14; 1.
DR PANTHER; PTHR14738:SF29; ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14; 1.
DR Pfam; PF14608; zf-CCCH_2; 5.
DR SMART; SM00356; ZnF_C3H1; 3.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU369058};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU369058};
KW RNA-binding {ECO:0000256|RuleBase:RU369058};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 570..595
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT ZN_FING 570..595
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 77..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 710 AA; 79725 MW; 160BA30500E7E404 CRC64;
MEIGTEISRK IRSAIKGKLQ ELGAYVDEEL PDYIMVMVAN KKSQDQMTED LSLFLGNNTI
RFTVWLHGVL DKLRSVTTDP SSLKSSDTNI FDSNVPSNKS SFSRGDERRH EAAVPPLAVS
STRPEKRESR VSTSSQEQKA TNVRQTYDDG AATRLMSTVK PLREPAPSED VIDIKPEPDD
LIDEDLNFVQ ENPLSQKKPT VTLTYGSSRP SIEIYRPPAS RNADSGAHLN RLQFQQQQNS
IHAAKQLDIQ TSRIYETGRL CEPEVLNSLE ETYSPFFRNS SEKMSIEEEN FRKRKLPVVS
SVVKVKKFSH DGEEEEEDDD GGSRTGSISS SVSVPAKPER RPSLPPSKQA NKNLILKAIS
EAQESVTKTT NYSAVSQKQT LPVAPRTRTS QEELLAEMVQ GQSRAPRISS PIKEEETKGD
NIDKSQDYYD MESMVHADTR SFILKKPKLS EEIVVAPNQE SGMKTADTLR VLSGHLMQTR
DLVQPDKPAS PKFIVTLDGV PSPPGYMSDQ EEDMSFEGMR PAHHTAASHE GLAGLLHPQQ
LHLLSRQLED PDGSFTNAEM SELSVAQKPE KLLERCKYWP ACKNGEECAY HHPVSPCKAF
PNCKFAEKCL FVHPNCKYDA KCTKPECPFT HMSRRIPVLP PKPVATPAPP SSSQLCRYFP
ACKKMECPFY HPKHCRFNTQ CTRPDCTFYH PTITVPPRHA LKWIRPQTSE
//
