ID A0A2Y9NSE2_DELLE Unreviewed; 2131 AA.
AC A0A2Y9NSE2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Dedicator of cytokinesis protein 7 isoform X1 {ECO:0000313|RefSeq:XP_022436955.1};
GN Name=DOCK7 {ECO:0000313|RefSeq:XP_022436955.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022436955.1};
RN [1] {ECO:0000313|RefSeq:XP_022436955.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022436955.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_022436955.1; XM_022581247.2.
DR STRING; 9749.A0A2Y9NSE2; -.
DR KEGG; dle:111178474; -.
DR InParanoid; A0A2Y9NSE2; -.
DR OrthoDB; 5480873at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08696; C2_Dock-C; 1.
DR CDD; cd11703; DHR2_DOCK7; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR037808; C2_Dock-C.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF78; DEDICATOR OF CYTOKINESIS PROTEIN 7; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 561..727
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1669..2105
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 138..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..971
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..435
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..914
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 944..971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2131 AA; 241711 MW; DC15B73EDE125079 CRC64;
MAERRAFAQK ISRTVAAEVR KQISGQYSGS PQLLKNLNIV GSISHHTTVP LTEAVDPVDL
EDYLITHPLA VDSGLLRDLI EFPPDDIEVV YSPRDCRTLV SAVPEESEMD PHVRDCIRSY
TEDWAIVIRK YHKLGTGFNP NTLDKQKERQ KGLPKQVFES DEAPDGNNYQ DEQDDLKRRS
MSIDDTPRGS WACSIFDLKN SLPDALLPNL LDRTPNEEID RQNDDQRKAN RHKELFALHP
SPDEEEPIER LSVPEVPKEH FGQRLLVKCL SLKFEIEIEP IFASLALYDV KEKKKISENF
YFDLNSEQMK GLLRPHVPPA AITTLARSAI FSITYPSQDV FLVIKLEKVL QQGDIGECAE
PYMIFKEADA TKNKEKLEKL KSQADQFCQR LGKYRMPFAW TAIHLMNIVS SAGSLERDST
EVEISTGERK GSWSERRNSS LVGRRSLERT TSGDDSCNLT SFRPATLTVT NFFKQEGDRL
SDEDLYKFLA DMRRPSSVLR RLRPITAQLK IDISPAPENP HYCLTPELLQ VKLYPDSRVR
PTREILEFPA RDVYVPNTTY RNLLYIYPQS LNFANRQGSA RNITVKVQFM YGEDPSNAMP
VIFGKSSCSE FSKEAYTAVV YHNRSPDFHE EIKVKLPATL TDHHHLLFTF YHVSCQQKQN
TPLETPVGYT WIPMLQNGRL KTGQFCLPVS LEKPPQAYSV LSPEVPLPGM KWVDNHKGVF
NVEVVAVSSI HTQDPYLDKF FALVNALDEH MFPVRIGDMR IMENNLENEL KSSIAALNSS
QLEPVVRFLY LLLDKLILLV VRPPVIAGQI VNLGQASFEA MASIINRLHK NLEGNHDQHG
RNSLLASYIY YVFRLPNTYP NSPSPGPGGL GGSVHYATMA RSAVRPASLN LNRSRSLSNS
NPDISGTPTS PDDEVRSIIG SKGLDRSNSW VNTGGPKAAP WGSNPSPSAE STQAMDRSCN
RMSSHTETSS FLQTLTGRLP TKKLFHEELA LQWVVCSGSV RESALQQAWF FFELMVKSMV
HHLYFNDKLD APRKSRFPER FMDDIAALVS TIASDIVSRF QKDTEMVERL NTSLAFFLND
LLSVMDRGFV FSLIKTCYKQ VSSKLYSLPT PSVLVSLRLD FLRIISSHEH YVTLNLPCSL
LTPPASPSPS VSSATSQSSG FSTTVQDQKI ANMFELSVPF RQQHYLAGLV LTELAVILDP
DAEGLFGLHK KVINMVHNLL SSHDSDPRYS DPQIKARVAM LYLPLIGIIM ETVPQLYDFT
ETHNQRGRPI CIATDDYESE SGSMISQTVA MAIAGTSVPQ LTRPGSFLLT STSGRQHTTF
SAESSRSLLI CLLWVLKNAD ETVLQKWFTD LSVLQLNRLL DLLYLCVSCF EYKGKKVFER
MNSLTFKKSK DMRAKLEEAI LGSIGARQEM VRRSRGQLER SPSGSAFGSQ ENLRWRKDMT
HWRQNTEKLD KSRAEIEHEA LIDGNLATEA NLIILDTLEI VVQTVSVTES KESILGGVLK
VLLHSMACNQ SAVYLQHCFA TQRALVSKFP ELLFEEETEQ CADLCLRLLR HCSSSIGTIR
SHASASLYLL MRQNFEIGNN FARVKMQVTM SLSSLVGTSQ NFNEEFLRRS LKTILTYAEE
DLELRETTFP DQVQDLVFNL HMILSDTVKM KEHQEDPEML IDLMYRIAKG YQTSPDLRLT
WLQNMAGKHS ERSNHAEAAQ CLVHSAALVA EYLSMLEDRK YLPVGCVTFQ NISSNVLEES
AVSDDVVSPD EEGICSGKYF TESGLVGLLE QAAASFSMAG MYEAVNEVYK VLIPIHEANR
DAKKLSTIHG KLQEAFSKIV HQSTGWERMF GTYFRVGFYG TKFGDLDEQE FVYKEPAITK
LAEISHRLEG FYGERFGEDV VEVIKDSNPV DKCKLDPNKA YIQITYVEPY FDTYEMKDRI
TYFDKNYNLR RFMYCTPFTL DGRAHGELHE QFKRKTILTT SHAFPYIKTR VNVTHKEEII
LTPIEVAIED MQKKTQELAF ATHQDPADPK MLQMVLQGSV GTTVNQGPLE VAQVFLSEIP
SDPKLFRHHN KLRLCFKDFT KRCEDALRKN KSLIGPDQKE YQRELERNYH RLKEALQPLI
NRKIPQLYKA VLPVTCHRDS FSRMSLRKMD L
//
