ID A0A2Y9NU06_DELLE Unreviewed; 829 AA.
AC A0A2Y9NU06;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2021, sequence version 2.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Leucine-rich repeat and guanylate kinase domain-containing protein isoform X2 {ECO:0000313|RefSeq:XP_022436456.2};
GN Name=LOC111178220 {ECO:0000313|RefSeq:XP_022436456.2};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022436456.2};
RN [1] {ECO:0000313|RefSeq:XP_022436456.2}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022436456.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022436456.2; XM_022580748.2.
DR AlphaFoldDB; A0A2Y9NU06; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00071; GMPK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23117; GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR23117:SF18; LEUCINE-RICH REPEAT AND GUANYLATE KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF14580; LRR_9; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00365; LRR_SD22; 6.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51450; LRR; 6.
PE 4: Predicted;
KW Kinase {ECO:0000313|RefSeq:XP_022436456.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Transferase {ECO:0000313|RefSeq:XP_022436456.2}.
FT DOMAIN 420..603
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..96
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 829 AA; 94255 MW; ADA0F108EF8140C4 CRC64;
MATSGRDPQL PKPSCLQGAV SSSRTGAQSK LLHSEKERQS LWSPFPMGQR PKNTFRKTSS
YLLQQLIHCS QESDVDRDYE DQEEGEDEGK VEFEESSESE MLNFEGEFDG VLREEVVAEK
LYKLGRSGSG TEQVYLSLTL SDLDLIDISI LCGYIHLQKL DLSVNKIEDL SCVSCMPYLL
ELNASQNKLT TFFNFKPPKN LKKVDFSYNQ ISEMCDLSAY ESLTKLILDS NEIAEINGLE
LCSSLNHLSL AKNKITAING LGMLPIKILC LSNNQIEKIT GLDDLRVLQI LDLSHNQISS
LQGLESHDFL EVINLEDNKI AELGEIEYIE NLRLLRVLNL LRNPIREKSD YCSFVIFMLL
RLTELDQKKI RVEEKVAAVN KYNPPPEVVA AQDHMTHVFN SLMQPQRIFD STLPSLDAPY
PMLVLAGPQA CGKRELAHRL CRQFSTYFRY GACHTTRLPY FGEGDRVDYH FISQEVFDEM
LNMGKFILTF NYGNHKYGLS RDTIEDIARD GLASCVHMEI EGVRSLKHSY FEPRYILVVP
MDKKKYEGYL RRKGLFSRIE IEFAVSRVDL YIKINQKYPG YFDAVVNADD LDVAYQTLSQ
LIREYLGLSE ATAKSLAPTT DTKKPQLKPE KTSKKFRALS EFESLDFADR NCFVKLWAKL
SGKNTPAERE SMARQYETAR QALMGKTPPH HTFLFQRGLV PAPVINSLRC FTALELKKSF
ELYGGYFKTP FGPSEKSGMD SSDSMKYSAL FESCPWSKDL PFRPPEDSIY SHPESTIGDI
EDQALKALHK QVFPCEKGSL QHRRHTISSI SRPGSNTKPT LPPIPQGRK
//
