ID   A0A2Y9NVQ9_DELLE        Unreviewed;       868 AA.
AC   A0A2Y9NVQ9;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Solute carrier family 12 member 7 isoform X3 {ECO:0000313|RefSeq:XP_022437031.1};
GN   Name=SLC12A7 {ECO:0000313|RefSeq:XP_022437031.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022437031.1};
RN   [1] {ECO:0000313|RefSeq:XP_022437031.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022437031.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC         Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC         Evidence={ECO:0000256|ARBA:ARBA00034453};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC       {ECO:0000256|ARBA:ARBA00010593}.
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DR   RefSeq; XP_022437031.1; XM_022581323.1.
DR   AlphaFoldDB; A0A2Y9NVQ9; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR000076; KCL_cotranspt.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR004842; SLC12A_fam.
DR   NCBIfam; TIGR00930; 2a30; 1.
DR   PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
DR   Pfam; PF03522; SLC12; 2.
DR   PRINTS; PR01081; KCLTRNSPORT.
PE   3: Inferred from homology;
KW   Chloride {ECO:0000256|ARBA:ARBA00023214};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Symport {ECO:0000256|ARBA:ARBA00022847};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT   TRANSMEM        33..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        57..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        236..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        336..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        360..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        394..418
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          199..475
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          489..606
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   DOMAIN          606..868
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
SQ   SEQUENCE   868 AA;  96312 MW;  3961D51ED31DB128 CRC64;
     MAWSQTYISP SAAIVRAEGA GGEATALLHN MRVYGTCTLA LMATVVFVGV KYVNKLALVF
     LACVVLSILA IYAGVVKTAF DPPDIPICLL GNRTLSRRSF DVCAKVHATN NGSATTALWS
     LFCNGSTASI SCDQYFAQNN VTEIQGIPGV VSGVLLDNLW SAYADKGVFV EKKGVPSVPV
     PEESRASGLP YVLTDITTYF TMLVGIYFPS VTGIMAGSNR SGDLKDAQKS IPSGTILAIV
     TTSFIYLSCI VLFGACIEGV ILRDKFGEAL QGNLVIGMLA WPSPWVIVIG SFFSTCGAGL
     QSLTGAPRLL QAIARDGIIP FLQVFGHGKA NGEPTWALLL TALICETGIL IASLDSVAPI
     LSMFFLMCYM FVNLACALQT LLRTPNWRPR FKYYHWTLSF LGMSLCFALM FICSWYYALC
     AMLIAGCIYK YIEYRGAEKE WGDGIRGLSL NAARYALLHV EHGPLHTKNW RPQVLVLVNL
     NAERCVKHPR LLSFTSQLKA GKGLTIVGSV LEGTFLDQHV EARQAEENIR ALMGTEKAKG
     FCQLVVSSSL RDGMSHLIQS AGLGGMKHNT VLMAWPEAWK REDSPFSWKN FVDTVRDTTA
     AQQALLVAKN VDLFPQNQER FSDGHIDVWW IVHDGGLLML LPFLLRQHKV WRRCQMRIFT
     VAQVHDNSIQ MKKDLQTFLY HLRISAEVEV VEMVENDISA FTYERTLVME QRSQMLRQMR
     LSKTEQEREA QLIHDRNTIS HSAVAAKTQA PCALDKVQMT WTKEKLVAEK YRNKDTSVSG
     FKDLFSLKPE WGSLDQSNVR RMHTAVKLNG VVLDKSQDAQ LVLLNMPGPP RNRQGDENYM
     EFLEVLTEGL NRVLLVRGSG REVVTIYS
//