ID A0A2Y9NXW8_DELLE Unreviewed; 1164 AA.
AC A0A2Y9NXW8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Disabled homolog 2-interacting protein isoform X6 {ECO:0000313|RefSeq:XP_022434533.1};
GN Name=DAB2IP {ECO:0000313|RefSeq:XP_022434533.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022434533.1};
RN [1] {ECO:0000313|RefSeq:XP_022434533.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022434533.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022434533.1; XM_022578825.2.
DR AlphaFoldDB; A0A2Y9NXW8; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF26; DISABLED HOMOLOG 2-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 172..206
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 197..315
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 375..566
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 898..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..868
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 919..938
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..959
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1022..1038
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1164 AA; 128291 MW; 042E99AF9478C3A8 CRC64;
MSAGGARKST GRPSYYYRLL RRPRLQRQRS RSRSRTRPAR ESPQERPGSR RSLPGSLSEK
SPSMEASAAT PFRVTGFLSR RLKGSIKRTK SQPKLDRNHS FRHILPGFRS AAAAASSASA
ADNERSHLMP RLKESRSHES LLSPSSAVEA LDLSMEEEVV IKPVHSSILG QDYCFEVTTS
SGSKCFSCRS AAERDKWMEN LRRAVHPNKD NSRRVEHILK LWVIEAKDLP AKKKYLCELC
LDDVLYARTT GKLKTDNVFW GEHFEFHNLP PLRTVTVHLY RETDKKKKKE RNSYLGLVSL
PAASVAGRQF VEKWYPVVTP NPKSGKGPGP MIRIKARYQT ITILPMEMYK EFAEHITNHY
LGLCAALEPI LSAKTKEEMA SALVHILQST GKVKDFLTDL MMSEVDRCGD EHLIFRENTL
ATKAIEEYLK LVGQKYLQDA LGEFIKALYE SDENCEVDPS KCSAADLPEH QGNLKMCCEL
AFCKIINSYC VFPRELKEVF ASWRQECSNR GRPDISERLI SASLFLRFLC PAIMSPSLFN
LLQEYPDDRT ARTLTLIAKV TQNLANFAKF GSKEEYMSFM NQFLEHEWTS MQRFLLEISN
PETVSNTAGF EGYIDLGREL SSLHSLLWEA VSQLEQSIVS KLGPLPRILR DVHTALSAPG
SGQLAGTSDL ASPPGSGSSS VSAGLQKVAI ENDVSGLIDF TRLPSPTPEN KDLFFVTRSS
GVQPSPARSS SYSEANEPDL QMANGGKSLS MVDLQDARTL DGEAGSPAGP DALAVDGQAP
AVQLVAGWPA RVAPVSLAGL ATVRRAGQTP STAGTSEGAP GRPQLLAPLS FQNPVYQMAA
GLPLSPRGLG DSGSEGHSSL SSHSNSEDLA AAAKLGSFSS TAEELGRRPG ELARRQVSLT
EKGGQPPGPR QNSAGPQRRI DQPPPPPPPP PPAPRGRTPP TLLSTLQYPR PSSGTLASAS
PDWAGPGARL RQQSSSSKGD SPELKPRAVH KQGPSPVSPN ALDRTAAWLL TMNAQLLEDE
GLGPDPPHRD RLRSKEELSQ AEKQDLAVLQ DKLRISTKKL EEYETLFKCQ EETTQKLVLE
YQARLEEGEE RLRRQQEDKD IQMKGIISRL MSVEEELKKD HAEMQAAVDS KQKIIDAQEK
RIASLDAANA RLMSALTQLK ESMH
//
