ID   A0A2Y9P0I9_DELLE        Unreviewed;       393 AA.
AC   A0A2Y9P0I9;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Short-chain dehydrogenase/reductase family 42E member 1 {ECO:0000313|RefSeq:XP_022438791.1};
GN   Name=SDR42E1 {ECO:0000313|RefSeq:XP_022438791.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022438791.1};
RN   [1] {ECO:0000313|RefSeq:XP_022438791.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022438791.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_022438791.1; XM_022583083.1.
DR   AlphaFoldDB; A0A2Y9P0I9; -.
DR   STRING; 9749.A0A2Y9P0I9; -.
DR   Ensembl; ENSDLET00000002532; ENSDLEP00000002231; ENSDLEG00000001808.
DR   KEGG; dle:111179462; -.
DR   InParanoid; A0A2Y9P0I9; -.
DR   OrthoDB; 5487986at2759; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   CDD; cd09812; 3b-HSD_like_1_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|RuleBase:RU004475};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU004475};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Transmembrane {ECO:0000256|RuleBase:RU004475};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU004475}.
FT   TRANSMEM        286..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004475"
FT   TRANSMEM        367..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004475"
FT   DOMAIN          12..284
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   393 AA;  43881 MW;  358F0E4FC41353B7 CRC64;
     MDSQNSLKET VLVTGGGGYF GFRLGCALNQ KGVRVILFDI SSPAQTIPEG IKFIHGDIRH
     LSDIEKAFQD VDVACVFHIA SYGMSGREQL NRNLIEEVNV GGTDNILQAC RRRGVPRLVY
     TSTFNVIFGG QVIRNGDESL PYLPLHLHPD HYSRTKSVAE KKVLEANGTA LERSDGVLRT
     CALRPAGIYG PGEQRHLPRI VSYIEKGLFK FVYGDPKSLV EFVHVDNLVQ AHILASVALK
     ADKGHIASGQ PYFISDGRPV NNFEFFRPLV EGLGYKFPSI RLPLTLIYYF AFLTETAHFI
     LGRLYNFQPF LTRTEVYKTG VTHYFSLEKA KKELGYEAQP FDLQEVVEWF KAHGHGRSPG
     SRDSECLVWD GLLVVLLVIA VLAWLPPSVI LSV
//