ID   A0A2Y9P102_DELLE        Unreviewed;       681 AA.
AC   A0A2Y9P102;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=G-protein-signaling modulator 2 {ECO:0000313|RefSeq:XP_022439880.1};
GN   Name=GPSM2 {ECO:0000313|RefSeq:XP_022439880.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022439880.1};
RN   [1] {ECO:0000313|RefSeq:XP_022439880.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022439880.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GPSM family.
CC       {ECO:0000256|ARBA:ARBA00006600}.
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DR   RefSeq; XP_022439880.1; XM_022584172.2.
DR   AlphaFoldDB; A0A2Y9P102; -.
DR   STRING; 9749.A0A2Y9P102; -.
DR   Ensembl; ENSDLET00000020827; ENSDLEP00000018893; ENSDLEG00000013744.
DR   KEGG; dle:111180088; -.
DR   InParanoid; A0A2Y9P102; -.
DR   OrthoDB; 4190321at2759; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0097575; C:lateral cell cortex; IEA:Ensembl.
DR   GO; GO:0097431; C:mitotic spindle pole; IEA:Ensembl.
DR   GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR   GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR   GO; GO:0001965; F:G-protein alpha-subunit binding; IEA:Ensembl.
DR   GO; GO:0005092; F:GDP-dissociation inhibitor activity; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:Ensembl.
DR   GO; GO:0051661; P:maintenance of centrosome location; IEA:Ensembl.
DR   GO; GO:0007052; P:mitotic spindle organization; IEA:Ensembl.
DR   GO; GO:1904778; P:positive regulation of protein localization to cell cortex; IEA:Ensembl.
DR   GO; GO:1905832; P:positive regulation of spindle assembly; IEA:Ensembl.
DR   GO; GO:0031291; P:Ran protein signal transduction; IEA:Ensembl.
DR   GO; GO:0060236; P:regulation of mitotic spindle organization; IEA:Ensembl.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR003109; GoLoco_motif.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR45954:SF3; G-PROTEIN-SIGNALING MODULATOR 2; 1.
DR   PANTHER; PTHR45954; LD33695P; 1.
DR   Pfam; PF02188; GoLoco; 4.
DR   Pfam; PF13374; TPR_10; 1.
DR   Pfam; PF13424; TPR_12; 2.
DR   Pfam; PF13176; TPR_7; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00390; GoLoco; 4.
DR   SMART; SM00028; TPR; 7.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50877; GOLOCO; 4.
DR   PROSITE; PS50005; TPR; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW   ProRule:PRU00339}.
FT   REPEAT          62..95
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          242..275
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   681 AA;  76227 MW;  718C8379941FF0EA CRC64;
     MEENLISMRE DHSFHVRYRM EASCLELALE GERLCKSGDC RAGVSFFEAA VQVGTEDLKT
     LSAIYSQLGN AYFYLHDYAK ALEYHHHDLT LARTIGDQLG EAKASGNLGN TLKVLGNFDE
     AVVCCQRHLD ISRELNDKVG EARALYNLGN VYHAKGKSFG CPGPQDVGEF PEEVRNALQA
     AVDYYEENLS LVTALGDRAA QGRAFGNLGN THYLLGNFRD AVIAHEQRLL IAKEFGDKAA
     ERRAYSNLGN AYIFLGEFET ASEYYRKTLL LARQLKDRAV EAQSCYSLGN TYTLLQDYEK
     AIDYHLKHLA IAQELNDRIG EGRACWSLGN AYTALGNHDQ AMHFAEKHLE ISREVGDRSG
     ELTAQLNLSD LQMVLGLSYS TNNSMMSENI EVDNSLHGAR PKFGRRHSME NMELMKLTPE
     KVQNWNSEIL AKQKPLIAKP SAKLLFVNRL KGKKYKSNSS TKVLQDASNS IDHRISNSQR
     KISADTIGDE GFFDLLSRFQ SNRMDDQRCC LKEQNSGSAS TAASATPPRM MLQTPSVSMV
     SPNTDEFLDL LASSQSRRLD DQRASFSNLP GLRLTQNNSQ SVLGHLMTND NKEPDEDFFD
     ILVKCQGSRL DDQRCAPPPA ATKGPTVPDE DFFSLILRSQ AKRMDEQRVL LQRDQNRDTE
     FGPKDLLQNN ALLELENSGK K
//