ID   A0A2Y9P128_DELLE        Unreviewed;      1354 AA.
AC   A0A2Y9P128;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X2 {ECO:0000313|RefSeq:XP_022438986.1};
GN   Name=PHLPP2 {ECO:0000313|RefSeq:XP_022438986.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022438986.1};
RN   [1] {ECO:0000313|RefSeq:XP_022438986.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022438986.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_022438986.1; XM_022583278.1.
DR   Ensembl; ENSDLET00000002008; ENSDLEP00000001759; ENSDLEG00000001453.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR   GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   CDD; cd13322; PH_PHLPP-like; 1.
DR   CDD; cd00143; PP2Cc; 1.
DR   CDD; cd17241; RA_PHLPP2; 1.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   PANTHER; PTHR48051; -; 1.
DR   PANTHER; PTHR48051:SF1; ZGC:77287; 1.
DR   Pfam; PF00560; LRR_1; 2.
DR   Pfam; PF13855; LRR_8; 2.
DR   Pfam; PF00481; PP2C; 1.
DR   SMART; SM00364; LRR_BAC; 12.
DR   SMART; SM00369; LRR_TYP; 12.
DR   SMART; SM00332; PP2Cc; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF81606; PP2C-like; 1.
DR   PROSITE; PS51450; LRR; 4.
DR   PROSITE; PS51746; PPM_2; 1.
PE   4: Predicted;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          816..1064
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51746"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1089..1134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1147..1184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1318..1354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..22
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1095..1133
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1154..1179
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1354 AA;  149744 MW;  A265BE7409AFBCC0 CRC64;
     MGEVEPGPAG PLEPPEPPEA PASRRPGGIR VLKRTMKRNG SRHCLNRRSR FGSRERDWLR
     EDVKRGCVYL YGADTATATA ASASATASSS SDLHLVLCTV DTPASEICAG EGRERLYLQL
     HGDLVRRLEP TERPLQIVYD YLSRLGFDDP VRIQEEAANP DLGCMLRFYG EKPCQMDHLD
     RILLSGIYNV RKGKTQLHKW AERLVVLCGT CLIVSSVKDC QTGKMHILPL VGGKVEEVKR
     RQYCLAFSSA GAQAQTYHVS FETLAEYQRW QRQSSKVVSQ RISTVDLSCH SLEEVPEHLF
     YSQDITYLNL RHNFMQLERP GGLDTFYKFS QLKGLNLSHN KLGSFPVLLC EISTLTELNL
     SCNGFHDLPS QIGNLLNLQT LCLDGNFLTT LPEELGNLQQ LSSLGISFNN FSQIPKVYEK
     LTMLDKVVMA GNQLEVLNLE VLNCMSHVKH VDLRMNHLKT MVIENLEGNK YITHMDLRDN
     QLTDLDLSSL CNLEQLHCER NQLRELTLSG FSLRTLYANS NRLTAVNVYP VPSLLTSLEL
     SRNLLECVPD WACEAKKIEI LDVSYNLLTE IPMRILSSLS LRKLMVGHNH VQNLPALVEH
     IPLEVLDIQH NLLTRLPDTL FSKALNLRYL NASANSLESL PSACTGEESL SALQLLYLTN
     NLLTDQCVPV LVGHPHLRIL HLANNQLQTF PASKLNKLEQ LEELNLSGNK LKTIPTTIAN
     CKRLHTLVAH SNHISIFPEI LQLPQIQFVD LSCNDLTEIL IPESLPATLQ DLDLTGNTNL
     VLEHKTLDTF SHITTLKIDQ KPLPTTDSTV TSTFWSHGLA EMAGQRNKLC ISALAVDNFA
     EGVGAVYGMF DGDRNEELPR LLQCTMADVL LEEVQQSTND TVFMAHTFLV SHRKLGMAGQ
     KLGSSALLCY IRPDTADPTS SFSLTVANVG TCQAVLCRSG KPLPLSKVFS LEQDPEEAQR
     VKDQKAIITE DNKVNGVTCC TRLLGCTYLY PWILPKPHIS STPLTIQDEL LILGNKALWE
     HLSYTEAVNA VCHVQDPLAA AKKLCTLAQS YGCQDNVGAM VVYLNVGEEG CTCEMNGLTL
     PGPVGFASTA AIKDPPKPTT PSSSSGIASE FSSEMSTSEV SSEVGSTASD EHNTVGLDAG
     LLSRPERRCS LHPTPTSGVF QRQPSCATFS SNQSDNGLDS DDDQPVEGVM TNGSKVEVEV
     DIHCCRGRQL ENSPTLRENS PTPCLEERAR GLVFGIRRQN SVSSGILLPV SKDKTELQKS
     PSTSCLYGKK LSNGSIVPLG DSLNLIEVAT EAPRKKTGYF AAPAQLEPED QFVVPRDLEE
     EVKEQMKHHQ ESRPEPDSSE EGRTELAEEF DTAL
//