ID A0A2Y9P1F4_DELLE Unreviewed; 426 AA.
AC A0A2Y9P1F4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Izumo sperm-egg fusion protein 1 isoform X1 {ECO:0000313|RefSeq:XP_022440859.1};
GN Name=IZUMO1 {ECO:0000313|RefSeq:XP_022440859.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022440859.1};
RN [1] {ECO:0000313|RefSeq:XP_022440859.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022440859.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Izumo family.
CC {ECO:0000256|ARBA:ARBA00009633}.
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DR RefSeq; XP_022440859.1; XM_022585151.1.
DR AlphaFoldDB; A0A2Y9P1F4; -.
DR STRING; 9749.A0A2Y9P1F4; -.
DR KEGG; dle:111180651; -.
DR InParanoid; A0A2Y9P1F4; -.
DR OrthoDB; 4610439at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; IEA:InterPro.
DR GO; GO:0035036; P:sperm-egg recognition; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029389; IZUMO.
DR InterPro; IPR032699; Izumo-Ig.
DR InterPro; IPR032700; IZUMO1.
DR PANTHER; PTHR35540; IZUMO SPERM-EGG FUSION PROTEIN 1; 1.
DR PANTHER; PTHR35540:SF1; IZUMO SPERM-EGG FUSION PROTEIN 1; 1.
DR Pfam; PF15005; IZUMO; 1.
DR Pfam; PF16706; Izumo-Ig; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..426
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016068430"
FT TRANSMEM 367..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 227..310
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 162..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..228
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 426 AA; 47594 MW; AE3C5A3287F4BC3E CRC64;
MGPWRLPLLV AALAGCLLPA RGCVMCDPNV VGALNSLETD YLPGHLEAKH HKNVMKRVKQ
AVEAFKDLPI DEDSYMGVVD EATLEKAAWS LLKDLKRIMD SDVKGELFVK ELFWTLHLAK
DNFASYAAQF QKAAFCPNKC GLMLQPLIWC STCQKQVHSC RKSSNCGGER AGRSRRGWRE
RGGARGEIKS LKRSETGDSQ QEKAGRDQVE GGWERAQNRE RASHSNPLFP ERKVKVHQME
DMILDCELNW HKISQGLTDY SFYRVWGNNS ETLMSKGKEP TLTKTMVRPK DAGTYRCELG
SVQSSPATII YFHVTVLPKR IVEEIPSPNT ETKDEVAPGE VTLDRPQTAT TLQSQSPKPE
KVLRSRLVGL LIWGFVVLIA SVATVILLSR SGKVIDFIKS SWFSTGSGAA QDSEVSEEKA
KESRRK
//
