ID A0A2Y9P400_DELLE Unreviewed; 419 AA.
AC A0A2Y9P400;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Izumo sperm-egg fusion protein 1 isoform X2 {ECO:0000313|RefSeq:XP_022440860.1};
GN Name=IZUMO1 {ECO:0000313|RefSeq:XP_022440860.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022440860.1};
RN [1] {ECO:0000313|RefSeq:XP_022440860.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022440860.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Izumo family.
CC {ECO:0000256|ARBA:ARBA00009633}.
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DR RefSeq; XP_022440860.1; XM_022585152.1.
DR AlphaFoldDB; A0A2Y9P400; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; IEA:InterPro.
DR GO; GO:0035036; P:sperm-egg recognition; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029389; IZUMO.
DR InterPro; IPR032699; Izumo-Ig.
DR InterPro; IPR032700; IZUMO1.
DR PANTHER; PTHR35540; IZUMO SPERM-EGG FUSION PROTEIN 1; 1.
DR PANTHER; PTHR35540:SF1; IZUMO SPERM-EGG FUSION PROTEIN 1; 1.
DR Pfam; PF15005; IZUMO; 1.
DR Pfam; PF16706; Izumo-Ig; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..419
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015846645"
FT TRANSMEM 360..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 220..303
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 154..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 419 AA; 46830 MW; A5E55537E2ADA250 CRC64;
MGPWRLPLLV AALAGCLLPA RGCVMCDPNV VGALNSLETD YLPGHLEAKH HKNVMKRVKQ
AVEAFKDLPI DEDSYMGVVD EATLEKAAWS LLKDLKRIMD SDVKGELFVK ELFWTLHLAK
DNFASYAAQF QKAGLMLQPL IWCSTCQKQV HSCRKSSNCG GERAGRSRRG WRERGGARGE
IKSLKRSETG DSQQEKAGRD QVEGGWERAQ NRERASHSNP LFPERKVKVH QMEDMILDCE
LNWHKISQGL TDYSFYRVWG NNSETLMSKG KEPTLTKTMV RPKDAGTYRC ELGSVQSSPA
TIIYFHVTVL PKRIVEEIPS PNTETKDEVA PGEVTLDRPQ TATTLQSQSP KPEKVLRSRL
VGLLIWGFVV LIASVATVIL LSRSGKVIDF IKSSWFSTGS GAAQDSEVSE EKAKESRRK
//
