ID A0A2Y9P4M3_DELLE Unreviewed; 4473 AA.
AC A0A2Y9P4M3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Dynein heavy chain 5, axonemal {ECO:0000313|RefSeq:XP_022437113.1};
GN Name=DNAH5 {ECO:0000313|RefSeq:XP_022437113.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022437113.1};
RN [1] {ECO:0000313|RefSeq:XP_022437113.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022437113.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR RefSeq; XP_022437113.1; XM_022581405.1.
DR STRING; 9749.A0A2Y9P4M3; -.
DR KEGG; dle:111178574; -.
DR InParanoid; A0A2Y9P4M3; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF13; DYNEIN CYTOPLASMIC 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1824..1960
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2103..2258
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2431..2579
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 746..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3056..3093
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3279..3334
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3585..3612
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 746..772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4473 AA; 512468 MW; D889DB30A58EFD7F CRC64;
MLDTADGGLL NSVRRLLSDI FIPALRATSH GWGELEGLPE ASSLQHEFLG SLEGFVSVLV
SAQESLKEKV NLQKCDIFEL KTLKEPLDYL TLANNPETLE KIEGCMKVWI KQTEQVLAGS
NQLRTEADDL GPRAELEYWK KRLSKFSYLL DQWKSPDVKT VLAVLAASRS KLLKTWREMD
IRITDAANEA KDNVKYLYTL EKCCDPLYSS DPMSMIDAIP ALINAIKMIY SISHYYNTSE
KITSLFVKVT NQMISACKAY ITNNGTASIW SQPQDVAVEK ILSAIKLKQE YQHCFHKTKQ
KLKRDPNEKQ FEFSEMYIFG KFETFHRRLA KIMDIFTTFN TYSVLQDSKI EGLENMVTKY
QGIVATIKEK EYNFLDQRKM DFEQDYEEFC KQTNDLHNEL QKFMDVTFEK IKNTNQALSM
LKKFERLDIP NLGIDDKYRR ILENYGADID MISKLYTKQK DDPPLARDQP PIAGKILWAR
QLFHRIQQPM QLFQQHPSVL QTAEAKPVIR SYNRVAKVLL AFEVLYHRAW LQQTEEIHIG
LEASLLVKAP GTGELFVNFD PQILTLFRET ECMSQMGLEV SPFAAALFRK RDIYKKNFSN
MKMILAEYQR VKSKMPPIIE QLMVPHLAKV DEALQPGLAA LTWTSLNIKM YLKDAFAKIK
ALELLIDRVN DLIEFRIDAI LEEMSSTPLC QLPREEPLTC EEFLQMTKDL CVNGAQTLHF
KSSLVEEAVN ELINILLDVE VSTKEDREKA SNMNSTDSKN EISAKREEGH SDTLTSSLNA
GVGLLPLTAV ARKKKETEVL QEGARELLSH FNHQNLGALL KVTRNTLEAV RKRIHSSHMT
SFRDSNSTSK MKQNVLPIFR ASITLAIPNI TMAPALEDIQ QTLNKAVECI VTVTKGVRQW
NSELLSKKKM HERKMAALQS NEDGDSDVEM GENEPQDTFE IASVNLPIPV QNRNYYKNVS
DNKEILKLVS VLSTIVNSTK KEVIASTDCF KRYNHIWQKE KEETIVTFIM KNPLLSEFES
QILYFQKLEQ EINTEPEYIC AGTIALYTAD LKFTLTAETK AWMVVIGRHC NKKYRSEMEN
IFTLVEEFSK KLNRPIKDLD DVRIAMVALK EIREQQISID FQVGPIEESY ALLNKYGLLI
AKEEMDKVDT LRYTWEKLLA RASEVQNELV SLQPSFRKEL ISTVEVFLQD CHQFYLDYDL
NGPMASGLRP QEASDRLIIF QNQFDNIYRK YITYTGGEEL FGLPVTQYPQ LLEIKKQLNL
LQKIYALYNS VIETVNSYHD ILWSEVNIEK INSELSEFQN RCRKLPRALK DWQAFLDLKK
TIDDFSECCP LLERMASKAM MERHWERITA LTGHSLDVGN ETFKLRHIME APLLKYKEEI
EDICISAVKE RDIEQKLKQV INEWDNKTFT FGNFKTRGEL LLRGDSTSEI ISNMEDSLML
LGSLLGNRYN MPFKGQIQKW VQYLSNSADI IENWMMVQNL WIYLEAVFVG GDIAKQLPKE
AKRFSNIDKS WVKIMTRAHE MPSVVQCCVG DETMGQLLPH LLDQLEICQK SLTGYLEKKR
LCFPRFFFVS DPALLEILGQ ASDTHAIQAH LLSVFDNIKT VKFHEKIYDR ILSVSSREGE
TIELDKPVMA EGNVEVWLNS LLEESQASLH LVIRQAAANI QETGFQVIEF LSSFPAQVGL
LGIQMIWTRD SEEALRNAKS DKKIMQKTNQ SFLELLNTLI DMTTKDLSSV ERVKYETLIT
IHVHQRDIFD DLCHMHIKSP TDFEWLKQCR FYFNEDSDKM MIHITDVPFI YQNEFVGCTD
RLVITPLTDR CYITLAQALG MSMGGAPAGP AGTGKTETTK DMGRCLGKYV VVFNCSDQMD
FRGLGRIFKG LAQSGSWGCF DEFNRIDLPV LSVAAQQISI ILTCKKERKK SFIFTDGDNV
TMNPEFGLFL TMNPGYAGRQ ELPENLKINF RSVAMMVPDR QIIIRVKLAS CGFTDNIVLA
RKFFTLYKLC EEQLSKQVHY DFGLRNILSV LRTLGAAKRA NPMDTESTIV MRVLRDMNLS
KLIDEDEPLF LSLIEDLFPN ILLDKAGYPE LEMAISRQVE EAGLINHPPW KLKVIQLFET
QRVRHGMMTL GPSGAGKTTC IHILMNAMAD CGKPHREMRM NPKAITAPQM FGRLDVATND
WTDGIFSTLW RKTLRAKKGD HIWIVLDGPV DAIWIENLNS ILDDNKTLTL ANGDRIPMAP
NCKIVFEPHN IDNASPATVS RNGMVFMSSS VLDWSPILEG FLKKRSPQEA EILRQLYTKS
FPDLYHFSIQ NLEHQMEMLE AFVIMQSINM LQGLIPSKEQ GGEVTPEHLG RLYVFSLMWS
VGAVLELDGR RRMEHWLCSQ ERLALDLPPL AGPDDTMFDY YVASDGKWMH WKTCTEEYVY
PSNITPEYGS ILVPNVDNVR TDFLIKTIAK QGKAVLLIGE QGTAKTVIIK GFMSKYDPES
HMIKSLNFSS ATTPLMFQRT IESYVDKRMG TTYGPPAGKK MTVFIDDVNM PIINEWGDQV
TNEIVRQLME QNGFYNLEKP GEFTSIVDIQ FLAAMIHPGG GRNDIPQRLK RQFSMFNCTL
PSDASVDKIF GVIGIGYYCT QRGFSEEVRD SVTKLVPLTR RLWQMTKIKM LPTPAKFHYV
FNLRDLSRIW QGMLNTTSEV IKEPDELLRL WKHECKRVIA DRFTVSDDVT WFDMTLVNLV
EEEFGEEKKL LVNCGIDTYF VDFLRDAPEA TGETSEEADT EMPKIYEPVE SFDQLKDRLN
MFLQLYNESI RGAGMDLVFF ADAMVHLVKI SRVIRTPRGN ALLVGVGGSG KQSLTRLASF
IAGYTSFQIT LTRSYNTSNL MEDLKILYRT AGQQGKGITF IFTDNEIKDE SFLEYMNNVL
SSGEVSNLFA CEEIDEINSD LISVMKIECP RRPPTNENLY DYFMSRVRQN LHIVLCFSPV
GERFRNRALK FPALISGCTI DWFSRWPKDA LVAVSEHFLS SYDIDCSLET KKEVVQCMGS
FQDGVAEKCV DYFQRFRRST HVTPKSYLSF IQGYKFIYGE KHVEVQTLAN RMNTGLEKLK
EASESVAALS KELEVKEKEL QMANEKADTV LKEVTVKAQA AEKVKVEVQK VKDKAQAIVD
SISKDKAIAE EKLEAAKPAL EEAEAALQTI KPSDIATVRT LGRPPHLIMR IMDCVLLLFQ
RKVSAVKIDL AKGCTIPSWQ ESLKLMTAGN FLQNLQQFPK DTINEEVIEF LNPYFEMADY
NIETAKRVCG NVAGLCSWTK AMASFFSINR EVLPLKANLV VQENRYVLAM QDLKKAQAEL
DDRQAELDVV QAEYEQAMTE KQTLLEDAER CRHKMQTAST LIGGLAGEKE RWTEQSKEFA
AQTKRLVGDV LLATAFLSYS GPFNQEFRNL LLNDWQKEMK ARKIPFGDNL NLNEMLIDAP
TISEWNLQGL PNDDLSIQNG IIVTKASRYP LLIDPQTQGK IWVKNKENQN ELQITSLNHK
YFRNHLEDSL SLGRPLLIED VAEELDPALD NVLERNFIKT GSTFKVKVGD KEVDVMDGFR
LYITTKLPNP AYTPEISART SIIDFTVTMK GLEDQLLGRV ILAEKQELEK ERTHLMEDVT
ANKRKMKELE DNLLYRLTST QGSLVEDESI ILVLSNTKNT AEEVTQKLEI SAETEIQINS
AREEYRPVAT RGSILYFLIT EMCLVSEMYQ TSLRQFLGLF DLSLARSVKS PITSKRIANI
IEHMTYEVYK YTARGLYEGH KFLFILLLTL KIDMQRNRVK HEEFFTLIKG GASLDLKACP
PKPSRWILDM TWLNLVELSK LRQFSDVLDQ ISRNEKMWKI WFDKKNPEEE PLPNAYDKSL
DCFRRLLLIR SWCPDRTIAQ ARKYIVDSMG EKYAEGVILD LEKTWEESDP RTPLICLLSM
GSDPTGSIIA LGKRLKRETR SVSMGQGQEV HARKLLQQTM ANGGWALLQN CHLGLDFMDE
LMDIIRETEI VHDAFRLWMT TEAHKQFPIT LLQMSIKFAN EPPQGLRAGL KRTYGGVSQD
LLDVSAVAQW KPMLYAVAFL HSTVQERRKF GPLGWNIPYE FNQADFNATV QFIQNHLDDM
DLKKGVSWTT VRYVIGEIQY GGRVTDDYDK RLLNTLTKVW FGENMFGPDF SFYQGYNIPK
CSTVDNYLQY IQSLPTYDSP EVFWLHPNAD ITYQSKLAKD VLDTILGIQP KDSSGGGDET
REAVVAQLAD DMLEKLPPDY GPFEVKERLQ KMGPFQPMNI FLRQEIDRMQ RVLTLVRSTL
TELKLAIDGT IIMSENLQDA LNCMFDARIP ARWKKESWVS STLGFWFTEL IERNCQFTSW
VFNDRPRCFW MTGFFNPQGF LTAMRQEITR ANEGWALDNM VLCNEVTKWM KDDISAPPTE
GIYVYGLYLE GAGWDKRNMK LIESKPKVLF ELMPVIRIYA ENNTVRDPRL YSCPIYKKPV
RTDLNYITAV DLRTAQAPEH WVLRGVALLC DVK
//