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Database: UniProt
Entry: A0A2Y9P4Y3_DELLE
LinkDB: A0A2Y9P4Y3_DELLE
Original site: A0A2Y9P4Y3_DELLE 
ID   A0A2Y9P4Y3_DELLE        Unreviewed;       428 AA.
AC   A0A2Y9P4Y3;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Intermediate conductance calcium-activated potassium channel protein 4 {ECO:0000313|RefSeq:XP_022441185.1};
GN   Name=KCNN4 {ECO:0000313|RefSeq:XP_022441185.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022441185.1};
RN   [1] {ECO:0000313|RefSeq:XP_022441185.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022441185.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   RefSeq; XP_022441185.1; XM_022585477.2.
DR   AlphaFoldDB; A0A2Y9P4Y3; -.
DR   STRING; 9749.A0A2Y9P4Y3; -.
DR   Ensembl; ENSDLET00000002396; ENSDLEP00000002110; ENSDLEG00000001716.
DR   KEGG; dle:111180779; -.
DR   InParanoid; A0A2Y9P4Y3; -.
DR   OrthoDB; 4200919at2759; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0031982; C:vesicle; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR   GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
DR   GO; GO:0016286; F:small conductance calcium-activated potassium channel activity; IEA:InterPro.
DR   GO; GO:0006816; P:calcium ion transport; IEA:Ensembl.
DR   GO; GO:0006884; P:cell volume homeostasis; IEA:Ensembl.
DR   GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR   GO; GO:0045332; P:phospholipid translocation; IEA:Ensembl.
DR   GO; GO:0050714; P:positive regulation of protein secretion; IEA:Ensembl.
DR   GO; GO:0050862; P:positive regulation of T cell receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0046541; P:saliva secretion; IEA:Ensembl.
DR   GO; GO:0030322; P:stabilization of membrane potential; IEA:Ensembl.
DR   Gene3D; 1.10.287.70; -; 2.
DR   InterPro; IPR004178; CaM-bd_dom.
DR   InterPro; IPR036122; CaM-bd_dom_sf.
DR   InterPro; IPR015449; K_chnl_Ca-activ_SK.
DR   InterPro; IPR013099; K_chnl_dom.
DR   PANTHER; PTHR10153:SF41; INTERMEDIATE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 4; 1.
DR   PANTHER; PTHR10153; SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL; 1.
DR   Pfam; PF02888; CaMBD; 1.
DR   Pfam; PF07885; Ion_trans_2; 1.
DR   Pfam; PF03530; SK_channel; 1.
DR   SMART; SM01053; CaMBD; 1.
DR   SUPFAM; SSF81327; Small-conductance potassium channel; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   4: Predicted;
KW   Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW   Ion channel {ECO:0000313|RefSeq:XP_022441185.1};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        25..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        54..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        207..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        238..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        263..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          305..378
FT                   /note="Calmodulin-binding"
FT                   /evidence="ECO:0000259|SMART:SM01053"
SQ   SEQUENCE   428 AA;  47791 MW;  B4B1088E641EEDC4 CRC64;
     MGGELVPGLG ALRRRKHLLE QERSLAGWAL ALAGIGIGLM VLHAEMLWFG GCLWAIHLFL
     VKCMISISTF SLLSLIVAFH TKEVQLFMTD NGLRDWRVAL TGRQAAQIVL ELAVCALHPA
     PVWRPPCAQI SGSPQTAVTQ SRPSFLGQAE ALLSLAMLLR LYLVPRALLL RSGVLLNASY
     RSIGALNQVR FRHWFVAKLY MNTHPGRLLL CLTLGLWLTT AWVLSVAERQ TVNATGHLSD
     TLWLIPITFL TIGYGDVVPG TTWGKIVCLC TGVMGVCCTA LLVAVVARKL EFNKAEKHVH
     NFMMDIQYTK EMKESAARVL QESWMFYKHT RRKDSGAARR HQRRLLAAIN RFRQVRLKHR
     KLREKVNSMV DISKMHMILC DLQLGLSTSH QALEKQIDAL AGRLDTLTEL LSAALGPRQL
     PEPSQEAT
//
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