ID   A0A2Y9P629_DELLE        Unreviewed;       926 AA.
AC   A0A2Y9P629;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN   Name=OSBPL1A {ECO:0000313|RefSeq:XP_022442559.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022442559.1};
RN   [1] {ECO:0000313|RefSeq:XP_022442559.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022442559.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the OSBP family.
CC       {ECO:0000256|RuleBase:RU003844}.
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DR   RefSeq; XP_022442559.1; XM_022586851.2.
DR   AlphaFoldDB; A0A2Y9P629; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd13285; PH_ORP1; 1.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10972:SF53; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 1; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF13857; Ank_5; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 3.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 3.
DR   PROSITE; PS50088; ANK_REPEAT; 3.
DR   PROSITE; PS01013; OSBP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW   ECO:0000256|RuleBase:RU003845};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT   REPEAT          47..79
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          80..112
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          175..207
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   DOMAIN          235..334
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          834..859
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        834..848
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   926 AA;  105087 MW;  4BDC40E9DE3E7370 CRC64;
     MSTEAEQQLL HHARNGNAEE VRQLLETMER NEVTADINCK GRSKSNLGWT PLHLACYFGH
     RQVVQDLLKA GAEVNVLNDM GDTPLHRAAF TGRKELVMLL LEYNAHTTVV NGNGQTAKEV
     THDKEIRNML EAVERTQQRK LEELLLAAAR EGRTAELTAL LNRPNPPAVN CSDQLGNTPL
     HCAAYRAHKQ CALKLLKSGA DPNLKNKNDQ KPLDLAQGAE MKHVLVGNKV IYKALKRYEG
     PLWKSSRFFG WRLFWVVLEH GVLSWYRKQP DAVHNIYRQG CKHLTQAVCT VKPTDSCLFF
     IKCFDDTVHG FRVPKNSLQQ TREDWLEAIE EHSAYSTHYC SQDQLTDDEE EDAVSAVDLK
     ESLEKAQICQ QRLDREISNF LRLIKECDVA KEMLPSFLQK VEVVSEASRE TCVALSDCLN
     LFTKQEGPPS LEITGLQRSL VNWLHVAVPQ SAFRCDDDNL GIFLQVVRNF KLEQEQEKNK
     ILSEALATLA TEHHELEQSL VKGSPPLSIL SEDEFYDALS DSESERSLSR LEAVTAHCFE
     EEGEHLRSRK YRMSEGKDCG GGDALSNGIK KHRTSLPSPM FSRNDFSIWS ILRKCIGMEL
     SKITMPVIFN EPLSFLQRLT EYMEHTYLIH KASSFADPVE RMQCVAAFAV SAVASQWERT
     GKPFNPLLGE TYELIRDDLG FRLISEQVSH HPPISAFHAE GLNNDFIFHG SIYPKLKFWG
     KSVEAEPKGT ITLELLEHNE AYTWTNPTCC VHNIIVGKLW IEQYGNVEIT NHKTADKCVL
     NFKPCGLFGK ELHKVEGYIQ DKSKKKLCAL YGKWTECLYS VDPATFDAYK KNDKKNTEEK
     KNSKQMSASE ESDEMPMPDS ESVFVIPGSV LLWRIAPRPP NSTQMYNFTS FAMVLNEVDK
     EMESVIPKTD CRLRPDIRAM ENGEIG
//