ID A0A2Y9P763_DELLE Unreviewed; 294 AA.
AC A0A2Y9P763;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=DNA excision repair protein ERCC-1 isoform X3 {ECO:0000313|RefSeq:XP_022441071.1};
GN Name=ERCC1 {ECO:0000313|RefSeq:XP_022441071.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022441071.1};
RN [1] {ECO:0000313|RefSeq:XP_022441071.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022441071.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ERCC1/RAD10/SWI10 family.
CC {ECO:0000256|ARBA:ARBA00008283}.
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DR RefSeq; XP_022441071.1; XM_022585363.2.
DR AlphaFoldDB; A0A2Y9P763; -.
DR Ensembl; ENSDLET00000000766; ENSDLEP00000000639; ENSDLEG00000000601.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR GO; GO:0070522; C:ERCC4-ERCC1 complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000110; C:nucleotide-excision repair factor 1 complex; IEA:Ensembl.
DR GO; GO:1990599; F:3' overhang single-stranded DNA endodeoxyribonuclease activity; IEA:Ensembl.
DR GO; GO:0003684; F:damaged DNA binding; IEA:Ensembl.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0001094; F:TFIID-class transcription factor complex binding; IEA:Ensembl.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0008340; P:determination of adult lifespan; IEA:Ensembl.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:Ensembl.
DR GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0036297; P:interstrand cross-link repair; IEA:Ensembl.
DR GO; GO:0045190; P:isotype switching; IEA:Ensembl.
DR GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:1905765; P:negative regulation of protection from non-homologous end joining at telomere; IEA:Ensembl.
DR GO; GO:0048477; P:oogenesis; IEA:Ensembl.
DR GO; GO:1904431; P:positive regulation of t-circle formation; IEA:Ensembl.
DR GO; GO:0060261; P:positive regulation of transcription initiation by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0035166; P:post-embryonic hemopoiesis; IEA:Ensembl.
DR GO; GO:0000720; P:pyrimidine dimer repair by nucleotide-excision repair; IEA:Ensembl.
DR GO; GO:0090399; P:replicative senescence; IEA:Ensembl.
DR GO; GO:0006979; P:response to oxidative stress; IEA:Ensembl.
DR GO; GO:0010165; P:response to X-ray; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR GO; GO:0006949; P:syncytium formation; IEA:Ensembl.
DR GO; GO:0090656; P:t-circle formation; IEA:Ensembl.
DR GO; GO:0061819; P:telomeric DNA-containing double minutes formation; IEA:Ensembl.
DR GO; GO:0009650; P:UV protection; IEA:Ensembl.
DR CDD; cd22325; ERCC1_C-like; 1.
DR Gene3D; 3.40.50.10130; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR047260; ERCC1-like_central_dom.
DR InterPro; IPR004579; ERCC1/RAD10/SWI10.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR010994; RuvA_2-like.
DR NCBIfam; TIGR00597; rad10; 1.
DR PANTHER; PTHR12749:SF0; DNA EXCISION REPAIR PROTEIN ERCC-1; 1.
DR PANTHER; PTHR12749; EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF03834; Rad10; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 96..209
FT /note="ERCC1-like central"
FT /evidence="ECO:0000259|Pfam:PF03834"
FT REGION 1..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 294 AA; 32421 MW; 836E40D84A332A3E CRC64;
MDEERVEKPA GPPTRKKFLI PVDEDEVPPP GAKPLFKSTR SLPTVETSPQ PAPQTYAEYA
ISGPPGGSGA TRPIGPEPLA GETPNQAPKP GAKSNSIIVS PRQRGNPVLR FVRNVPWEFG
DVLPDYVLGQ STCALFLSLR YHSLHPDYIH GRLQSLGKSF ALRVLLVQVD VKDPQQALKE
LAKMCILADC TLILAWSPEE AGRYLETYKA YEQKPADLLM EKLEQDFVSR VTECLTTVKS
VNKTDSQTLL TTFGSLEQLI AASREDLALC PGLGPQKARR LFDVLHEPFL KVPR
//