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Database: UniProt
Entry: A0A2Y9P763_DELLE
LinkDB: A0A2Y9P763_DELLE
Original site: A0A2Y9P763_DELLE 
ID   A0A2Y9P763_DELLE        Unreviewed;       294 AA.
AC   A0A2Y9P763;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=DNA excision repair protein ERCC-1 isoform X3 {ECO:0000313|RefSeq:XP_022441071.1};
GN   Name=ERCC1 {ECO:0000313|RefSeq:XP_022441071.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022441071.1};
RN   [1] {ECO:0000313|RefSeq:XP_022441071.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022441071.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the ERCC1/RAD10/SWI10 family.
CC       {ECO:0000256|ARBA:ARBA00008283}.
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DR   RefSeq; XP_022441071.1; XM_022585363.2.
DR   AlphaFoldDB; A0A2Y9P763; -.
DR   Ensembl; ENSDLET00000000766; ENSDLEP00000000639; ENSDLEG00000000601.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR   GO; GO:0070522; C:ERCC4-ERCC1 complex; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0000110; C:nucleotide-excision repair factor 1 complex; IEA:Ensembl.
DR   GO; GO:1990599; F:3' overhang single-stranded DNA endodeoxyribonuclease activity; IEA:Ensembl.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:Ensembl.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR   GO; GO:0001094; F:TFIID-class transcription factor complex binding; IEA:Ensembl.
DR   GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR   GO; GO:0008340; P:determination of adult lifespan; IEA:Ensembl.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:Ensembl.
DR   GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0036297; P:interstrand cross-link repair; IEA:Ensembl.
DR   GO; GO:0045190; P:isotype switching; IEA:Ensembl.
DR   GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR   GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR   GO; GO:1905765; P:negative regulation of protection from non-homologous end joining at telomere; IEA:Ensembl.
DR   GO; GO:0048477; P:oogenesis; IEA:Ensembl.
DR   GO; GO:1904431; P:positive regulation of t-circle formation; IEA:Ensembl.
DR   GO; GO:0060261; P:positive regulation of transcription initiation by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0035166; P:post-embryonic hemopoiesis; IEA:Ensembl.
DR   GO; GO:0000720; P:pyrimidine dimer repair by nucleotide-excision repair; IEA:Ensembl.
DR   GO; GO:0090399; P:replicative senescence; IEA:Ensembl.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:Ensembl.
DR   GO; GO:0010165; P:response to X-ray; IEA:Ensembl.
DR   GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR   GO; GO:0006949; P:syncytium formation; IEA:Ensembl.
DR   GO; GO:0090656; P:t-circle formation; IEA:Ensembl.
DR   GO; GO:0061819; P:telomeric DNA-containing double minutes formation; IEA:Ensembl.
DR   GO; GO:0009650; P:UV protection; IEA:Ensembl.
DR   CDD; cd22325; ERCC1_C-like; 1.
DR   Gene3D; 3.40.50.10130; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   InterPro; IPR047260; ERCC1-like_central_dom.
DR   InterPro; IPR004579; ERCC1/RAD10/SWI10.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR010994; RuvA_2-like.
DR   NCBIfam; TIGR00597; rad10; 1.
DR   PANTHER; PTHR12749:SF0; DNA EXCISION REPAIR PROTEIN ERCC-1; 1.
DR   PANTHER; PTHR12749; EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1; 1.
DR   Pfam; PF14520; HHH_5; 1.
DR   Pfam; PF03834; Rad10; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR   SUPFAM; SSF47781; RuvA domain 2-like; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT   DOMAIN          96..209
FT                   /note="ERCC1-like central"
FT                   /evidence="ECO:0000259|Pfam:PF03834"
FT   REGION          1..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..55
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   294 AA;  32421 MW;  836E40D84A332A3E CRC64;
     MDEERVEKPA GPPTRKKFLI PVDEDEVPPP GAKPLFKSTR SLPTVETSPQ PAPQTYAEYA
     ISGPPGGSGA TRPIGPEPLA GETPNQAPKP GAKSNSIIVS PRQRGNPVLR FVRNVPWEFG
     DVLPDYVLGQ STCALFLSLR YHSLHPDYIH GRLQSLGKSF ALRVLLVQVD VKDPQQALKE
     LAKMCILADC TLILAWSPEE AGRYLETYKA YEQKPADLLM EKLEQDFVSR VTECLTTVKS
     VNKTDSQTLL TTFGSLEQLI AASREDLALC PGLGPQKARR LFDVLHEPFL KVPR
//
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