ID A0A2Y9PBV5_DELLE Unreviewed; 1945 AA.
AC A0A2Y9PBV5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Myosin-16 isoform X1 {ECO:0000313|RefSeq:XP_022443485.1};
GN Name=LOC111181914 {ECO:0000313|RefSeq:XP_022443485.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022443485.1};
RN [1] {ECO:0000313|RefSeq:XP_022443485.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022443485.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril
CC {ECO:0000256|ARBA:ARBA00004657}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022443485.1; XM_022587777.2.
DR STRING; 9749.A0A2Y9PBV5; -.
DR KEGG; dle:111181914; -.
DR InParanoid; A0A2Y9PBV5; -.
DR OrthoDB; 2877572at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd14934; MYSc_Myh16; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 4.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615:SF40; MYOSIN HEAVY CHAIN, MUSCLE-RELATED; 1.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 35..84
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 88..772
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 650..672
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 833..1917
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 181..188
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1945 AA; 224598 MW; 4A92692F2CB1683C CRC64;
MPSASRGECG DDVDPMPFLT PSEKERIEAM NKPYDIKRSC WVKDEKEGFI SGEIQSEQGD
QVTVKTITNQ TLTMKKDDIQ QMNPPKFYQV SDMANMTFLN EASVLDNLRQ RYISMRIYTY
SGLFCVTVNP YRWLPIYGAR VANMYRGKKR TEMPPHLFSI SDVAYHDMLM ERENQSMLIT
GESGAGKTEN TKKVIQYFAN IGGTGKQSSD GKGSLEDQII QANPVLEAFG NAKTTRNNNS
SRFGKFIRIH FGTTGKLAGA DIESYLLEKS RVISQQAAER GYHIFYQILS NKKPELVESL
LLVPNPKEYF WVSQGVTMVD NMDDGEELQV TDVAFDVLGF SSEEKIGVYK LTGGIMHFGN
MKFKQKPREE QAEVDTTEVA DKVAHLMGLN SGELQKGITR PRVKVGNEFV QKGQNMEQCQ
NSIGALGKAI YDKMFKWLVV RINKTLDTKM QRQFFIGVLD IAGFEIFEFN SFEQLCINFT
NEKLQQFFNH HMFVLEQEEY KKEGIDWVFI DFGLDLQACI DLLEKPMGIF SILEEQCVFP
KATDATFKAA LYDNHLGKSS NFLKPKGSKG KGPEAHFELV HYAGTVGYNI TGWLEKNKDP
LNETVVGLFQ KSSLGLLALL FKEEEAPTGS KKQKRGSSFM TVSNFYREQL NKLMATLHST
SPHFVRCIVP NEFKQSGVVD AHLIMHQLAC NGVLEGIRIC RKGFPNRLQY PEFKQRYQVL
NPSVISQGFV DNKKASELLL GSIALDVNEY KIGHTKVFFR AGVLAKLEDM RDERLAKIMT
MLQCRLRGFL MRVEFKKMLE RRIGLKVIQR NTRKFLELRF WGWWKLYNKV KPLLNVARQE
EEMKAKEEEL RNAMAKTQEL LDKIKDLEEK MATLSQEKND LTIQLQAEQE NLIDVEERLT
QMMKTKMELE SQISDMRERL EEEEGTSASL SATKRKLEGE LSDLKRDLEG LETTLAKMEK
EKQALDHKVR TLTGDLSLRE DSIAKLQKEK RALEELHQKT LDDLQAEEDK VNHLTKNNSK
LSTQIHELED NWEQEKKIRA EVEKARRKAE SDLKMTIDNL NEMERSKLDL EEVVKKRDME
INSVNSKYED EQSLNSTLQR KLKEHQARIE ELEEELEAER AMRAKVEKQR SDLSRDLEDL
SDRLEEAGGA TSAQIEQNRK REAELLKLRR ELEEAALQSE AAASTLRKKH TDSMAELTEH
VENLQRVKSK LEKDKQVMKA EIDDLNASVE TIQKSKMNAE AHVRKLEDNL SEANAKVAEL
ERNQAEINAI RTRLQAENSE LSREYEESQS RLNQILRIKT SLTSQVDDYK RQLDEESKSR
STAVVSLANT KHDLDLLKEQ LEEEQGGKSE LQRLVSKLNT EVTTWRTKYE TDAIQRTEEL
EETKRKLAAR LQEAEETAEA AQARAASLEK NKQRLQAEVE DLTIDLEKAN AAAAALDKKQ
RVFDKMLAEW QQKCEELQVE VDTSQKECRM YMTESFKIKT VYEECLEHLE SVKKENKTLQ
EEIKELIDQL GEGGRSIHEL QKMKKKLEIE KEELQVALEE AESSLEVEES KVIRIQLELA
QVKADIDRRI HEKEEEFEAT RKNHQRAIES LQASLEAEAK GRAEALRLKK KMETDLNEME
IQLDHANKNN SELVKTLKRL QQQIKDLQIQ MDEDARQHEE LREQYNLQER RLSLLQTEMD
EVRSALEGSE RSRKLLEQEV VEVTERHNEL NVQNQSLLVV KRKLESDVQR ISNEHEELIS
EFRSVDERAK KAMTDAARMA EELRQEQDHC MHLEKIKKNY EVTIKDLQAK MEEAEQLALK
GGKRTIMKLE ARIKELETEL DGEQKQHVET VKTLRKNERR LKDLVFQTEE DHKTNQRMQE
LVEKLQNKLK VYKRQIEEAE EQANQTLARY RKTVHELDDA EERAGMAETA LNKLRTRHRV
AGKGITSVEI IQVSKTGTSK TLAEE
//
