ID A0A2Y9PCH7_DELLE Unreviewed; 653 AA.
AC A0A2Y9PCH7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=RNA-binding E3 ubiquitin-protein ligase MEX3C {ECO:0000313|RefSeq:XP_022440173.1};
GN Name=MEX3C {ECO:0000313|RefSeq:XP_022440173.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022440173.1};
RN [1] {ECO:0000313|RefSeq:XP_022440173.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022440173.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_022440173.1; XM_022584465.1.
DR AlphaFoldDB; A0A2Y9PCH7; -.
DR STRING; 9749.A0A2Y9PCH7; -.
DR Ensembl; ENSDLET00000006509; ENSDLEP00000005873; ENSDLEG00000004392.
DR KEGG; dle:111180250; -.
DR InParanoid; A0A2Y9PCH7; -.
DR OrthoDB; 50983at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0003415; P:chondrocyte hypertrophy; IEA:Ensembl.
DR GO; GO:0097009; P:energy homeostasis; IEA:Ensembl.
DR GO; GO:0045598; P:regulation of fat cell differentiation; IEA:Ensembl.
DR CDD; cd22423; KH-I_MEX3_rpt1; 1.
DR CDD; cd22424; KH-I_MEX3_rpt2; 1.
DR CDD; cd16722; RING-HC_MEX3C; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047228; KH-I_MEX3_rpt1.
DR InterPro; IPR047226; KH-I_MEX3_rpt2.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR047227; MEX3.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23285; RING FINGER AND KH DOMAIN CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23285:SF8; RNA-BINDING E3 UBIQUITIN-PROTEIN LIGASE MEX3C; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00322; KH; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00117}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 602..642
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..36
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..133
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 653 AA; 68677 MW; 62C5914D71190814 CRC64;
MPSGSSAALA LAAAPAPLPQ PPPPPPPPPL PPPAGGPELE GDGLLLRERL AALGLDDPSP
AESGAPALRA AAAQGQARRA AGLSPEERAP SGRPGVSEAA ELELEEDEEE EGEEAELDGD
LLEEEELEEA EEEDRPSLLL LSPPAAAASQ TQPIPGGSLG SVLLPAAGFD AREAAAAAGV
LYGGDDAQGM MAAMLSHAYG PGGCGAAAAA LNGEQAALLR RKSVNTTECV PVPSSEHVAE
IVGRQGCKIK ALRAKTNTYI KTPVRGEEPI FVVTGRKEDV AMAKREILSA AEHFSMIRAS
RNKNGPALGG LSCSPNLPGQ TTVQVRVPYR VVGLVVGPKG ATIKRIQQQT HTYIVTPSRD
KEPVFEVTGM PENVDRAREE IEMHIAMRTG NYIELNEEND FHYNGTDVSF EGGTLGSAWL
SSNPVPPSRA RMISNYRNDS SSSLGSGSTD SYFGSNRLAD FSPTSPFSTG NFWFGDTLPS
VGSEDLAVDS PAFDSLPTSA QTIWTPFEPV NPLSGFGSDP PANMKTQRRG SQPSTPRLSP
TFPESIEHPL ARRVRSDPPS TGSHVGLPIY IPAFSNGTNS YSSSNGGSTS SSPPESRRKH
DCVICFENEV IAALVPCGHN LFCMECANKI CEKRTPSCPV CQTAVTQAIQ IHS
//
