ID A0A2Y9PD34_DELLE Unreviewed; 559 AA.
AC A0A2Y9PD34;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Zinc finger protein 404 {ECO:0000313|RefSeq:XP_022441174.1, ECO:0000313|RefSeq:XP_022441176.1};
GN Name=ZNF404 {ECO:0000313|RefSeq:XP_022441174.1,
GN ECO:0000313|RefSeq:XP_022441176.1, ECO:0000313|RefSeq:XP_022441177.1,
GN ECO:0000313|RefSeq:XP_030617102.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022441177.1};
RN [1] {ECO:0000313|RefSeq:XP_022441174.1, ECO:0000313|RefSeq:XP_022441176.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022441174.1,
RC ECO:0000313|RefSeq:XP_022441176.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC {ECO:0000256|ARBA:ARBA00003767}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR RefSeq; XP_022441174.1; XM_022585466.2.
DR RefSeq; XP_022441176.1; XM_022585468.2.
DR RefSeq; XP_022441177.1; XM_022585469.2.
DR RefSeq; XP_030617102.1; XM_030761242.1.
DR STRING; 9749.A0A2Y9PD34; -.
DR KEGG; dle:111180774; -.
DR OrthoDB; 3958685at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 15.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23226:SF410; RCG54037; 1.
DR PANTHER; PTHR23226; ZINC FINGER AND SCAN DOMAIN-CONTAINING; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 13.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 8.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 15.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 13..85
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 138..165
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 166..193
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 194..221
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 222..249
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 250..277
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 278..305
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 306..333
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 334..361
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 362..389
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 390..417
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 418..445
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 446..473
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 474..501
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 502..529
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 530..557
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 559 AA; 65885 MW; DCC57E6F269FC131 CRC64;
MIGSSKTMGR VPLTFSDVAI DFSQEEWECL NSDQRNLYRD VMLENYTNLI SLDIDFTSES
NKLSSEESSY EVNSYHWETM NRSKTFNFMA FIFRNDSQNR TKFERQQKPK MGYFNHMIFR
KHISLPLPQR LHTKEKSYEC KECRKGFRKY SHLIEHLRDH SGVRPYECKE CGKVFIVLQH
FIRHKKSHTD LKPFECNGCE KAFRFYSQLI QHQIIHTGVK PYECKQCGKA FRRHSHLTEH
QKIHIGLKPY KCKECGETFR LYRHMCLHQK IHHGVKPYIC KECGRAFGHR SSLYQHKKIH
SGEKPYKCKQ CGKAFVRSYL LIEHQRSHTG EKPHECKECG KAFSRGSSLL KHKRIHSSEK
LYDCKECGKA FCRGSQLTQH QRIHTGEKPH ECKECGKTFK LHSYLIQHQI IHSDLKPYEC
KQCGKAFSRV GDLKTHQSIH AGEKPYECKE CGKTFRLNSQ LIYHQTIHTG LKPYICKECK
KAFRSISGLS QHKRIHTGEK PYECKECGKA FNRSDRLAQH LRIHTGVKPH KCKECGKAFT
RCYQLTQHQR FHIGEKVLM
//
