ID A0A2Y9PE38_DELLE Unreviewed; 1723 AA.
AC A0A2Y9PE38;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Trinucleotide repeat-containing gene 6C protein isoform X2 {ECO:0000313|RefSeq:XP_022445189.1};
GN Name=TNRC6C {ECO:0000313|RefSeq:XP_022445189.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022445189.1};
RN [1] {ECO:0000313|RefSeq:XP_022445189.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022445189.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GW182 family.
CC {ECO:0000256|ARBA:ARBA00007302}.
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DR RefSeq; XP_022445189.1; XM_022589481.2.
DR Ensembl; ENSDLET00000016200; ENSDLEP00000014671; ENSDLEG00000010797.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd12713; RRM_TNRC6C; 1.
DR CDD; cd14283; UBA_TNR6C; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR019486; Argonaute_hook_dom.
DR InterPro; IPR026805; GW182_M_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR041917; TNR6C_UBA.
DR InterPro; IPR032226; TNRC6_PABC-bd.
DR InterPro; IPR034927; TNRC6C_RRM.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR13020; TRINUCLEOTIDE REPEAT-CONTAINING GENE 6; 1.
DR PANTHER; PTHR13020:SF9; TRINUCLEOTIDE REPEAT-CONTAINING GENE 6C PROTEIN; 1.
DR Pfam; PF10427; Ago_hook; 1.
DR Pfam; PF12938; M_domain; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF16608; TNRC6-PABC_bdg; 1.
DR Pfam; PF00627; UBA; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 930..975
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 902..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 997..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1060..1102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1208..1313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1346..1374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1389..1446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1477..1519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1633..1656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..793
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..826
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..916
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1060..1075
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1243..1258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1265..1296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1406..1446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1477..1498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1723 AA; 178012 MW; 35DBCF3456BBF10A CRC64;
MATGSAQGSF TGHTKKTNGN NGTNGALVQS PCNQSALGAG GANGNGNAAR VWGVATGSSS
GLAHCSLSGG DGKMDNMIGD GRSQNCWGAS NSNAGINLNL NPNANPAAWP VLGHEGTVAT
GNPSSICSPV SAIGQNMGNQ NGNPAGTLGA WGNLLPQEST EPQTSTSQNV SFSVQPQNLN
TDGPNNTNPL NSSPNPINAV QTNGLPNWGM AVGMGAIIPP HLQGLPGANG SSVSQVSGGG
SEGISSSVWG LSPGNPATGN SNSGFNQGNG DTVNSASSAK QNGSSSAVHK EGNGGNAWDS
GPPAGPGILA WGRGSGNHGV GNLHSGAWGH PSRSPSNGVN GDWGKPPNQH SSSDINGKGS
TGWESPSVGS QNPATQPGSE HTNSWAKAAS SGTTASEGSS DGSGSHNEGS AGREGTEGRR
RDKGILDQGH IQLPRNDLDP RVLSNTGWGQ TPVKQNTAWE FEESPRSERK NDNGTEAWGC
AATQPSNSGG KNDGSIMNST NTSSVSGWVS SPPAAAPANT GWGDSSSKAP NGPGVWGDTI
SSTAVNNAAA AKSGHAWSGT VNQEDKSPTW GEPQKPRAQN WGDGHKSNPA WSAGGGDWAD
SSSVLGHLGD GKKNGSGWDA DSNRSGSGWN EAPRSGTSGW GNGTNAKVNP GTSWGESLKP
GPQQNWASKP QDSSASNWGG ATSVKQTGTG WIGGPVPVKQ KDSSEATGWE EPSPPSIRRK
MEIDDGTSAW GDPSNYNNKT VNMWDRNNPG IQSSASVSTT TSTSTTTAST NANVAEAPPT
HQASAQLNRS PLLGPVSSGW GEMPNVHSKA ENSWGEPSSP STLVDNGTAA WGKPPSSGSG
WGDQPTEPAV TFGRAGAPAA APALCKPASK SMQEGWGSGG DDANLGAGQW EDEDGGMWNN
AASQESTSSC SSWGNAPKKG LQKGMKTSGK QDEAWIMTRL IKQLTDMGFP REPAEEALKS
NNMNLDQAMS ALLEKKVDVD KRGLGVTDYN GMVTKPLGCR PPISKESSAD RPTFLDKDGG
LVEEPTTSPF LPSPSLKLPL SNSALPNQAL GGIASGLGMQ NLNSSRQTPS GNLGMFGSSG
AAPARTMQQP PQPPVQPLSS SQPSLRAQVP QFLSPQVQAQ LLQFAAKNIG LNPALLTSPV
NPQHMTMLNQ LYQLQLAYQR LQIQQQMLQA QRNVSGPMRQ QEQQVARTIT NLQQQIQQHQ
RQLAQALLVK PPPPPPPLSL HPSAGKSALD SFPPHPQAPG LPDLQTKEQQ SSPSTFAPYP
LAGLNPNMNV SSMDMTGGLS VKDPSQSQSR LPQWTHPNPM DNLPGAASPL DQNPSKHGAI
PGGLSIGPPA KSSIDDSYGR YDLIQSSESA ASPPVAVPHS WSRAKSDSDK ISNGSSINWP
PEFHPGVPWK GLQNIDPEND PDVTPGSVPT GPTINTTIQD VNRYLLKSGG SSPPSSQSAT
LPSSSAWPLA ASGYSRSLSS LVPAPSIAGK LSDIKSTWSS GPASHTQASL SHELWKVPRN
TTAPTRPPPG LTNPKPSSTW GASPLGWTSS YSSGSAWSTD TSGRTSSWLV LRNLTPQIDG
STLRTLCLQH GPLITFHLNL TQGNAVVRYS SKEEAAKAQK SLHMCVLGNT TILAEFAGEE
EVNRFLAQGQ ALPPTSSWQP SAGTSQTRLG ASGSSHGLVR SDTGHWNAPC LAGKGSSDLL
WGGVPQYSSS LWGPPSSDDG RVIGSPTPLN TLLPGDLLSG ESI
//
