ID A0A2Y9PF07_DELLE Unreviewed; 527 AA.
AC A0A2Y9PF07;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Argininosuccinate lyase {ECO:0000256|ARBA:ARBA00019698};
GN Name=ASL {ECO:0000313|RefSeq:XP_022443866.1,
GN ECO:0000313|RefSeq:XP_022443867.1, ECO:0000313|RefSeq:XP_030619551.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022443866.1};
RN [1] {ECO:0000313|RefSeq:XP_022443866.1, ECO:0000313|RefSeq:XP_022443867.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022443866.1,
RC ECO:0000313|RefSeq:XP_022443867.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57472; EC=4.3.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00033644};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24021;
CC Evidence={ECO:0000256|ARBA:ARBA00033644};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:24022;
CC Evidence={ECO:0000256|ARBA:ARBA00033644};
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004730}.
CC -!- PATHWAY: Nitrogen metabolism; urea cycle; L-arginine and fumarate from
CC (N(omega)-L-arginino)succinate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005214}.
CC -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC subfamily. {ECO:0000256|ARBA:ARBA00010755}.
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DR RefSeq; XP_022443866.1; XM_022588158.2.
DR RefSeq; XP_022443867.1; XM_022588159.2.
DR RefSeq; XP_030619551.1; XM_030763691.1.
DR STRING; 9749.A0A2Y9PF07; -.
DR KEGG; dle:111182080; -.
DR OrthoDB; 2722228at2759; -.
DR UniPathway; UPA00068; -.
DR UniPathway; UPA00158; UER00273.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IEA:InterPro.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR GO; GO:0000050; P:urea cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 2.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR HAMAP; MF_00006; Arg_succ_lyase; 1.
DR InterPro; IPR029419; Arg_succ_lyase_C.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR NCBIfam; TIGR00838; argH; 1.
DR PANTHER; PTHR43814; ARGININOSUCCINATE LYASE; 1.
DR PANTHER; PTHR43814:SF1; ARGININOSUCCINATE LYASE; 1.
DR Pfam; PF14698; ASL_C2; 1.
DR Pfam; PF00206; Lyase_1; 2.
DR PRINTS; PR00145; ARGSUCLYASE.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 2.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|RefSeq:XP_022443866.1,
KW ECO:0000313|RefSeq:XP_022443867.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Urea cycle {ECO:0000256|ARBA:ARBA00022436}.
FT DOMAIN 11..242
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 303..368
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 431..498
FT /note="Argininosuccinate lyase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14698"
SQ SEQUENCE 527 AA; 58375 MW; 277A203BBA183810 CRC64;
MASESGKLWG GRFVGAVDPI MEKFNSSITY DQHLWEVDVQ GSKAYSRGLQ KAGILTKTEM
DQILQGLDKV AEEWAQGTFK LNPNDEDIHT ANERRLKELI GETAGKLHTG RSRNDQVVTD
LRLWMRQNCS TLSALLRELI RTMVDRAEAE RDILFPGYTH LQRAQPIRWS HWILSHAVAL
TRDSERLLEV QKRINVLPLG SGAIAGNPLG VDRELLRAEL NFGAITLNSM DATSERDFVG
ESWALARPPS RASPLQCVLP LSPRPASSPA SYHPHMAHRT FSRLGEGQGL VTRQPALPLL
PQAEFLFWAS LCMTHLSRMA EDLILYGTKE FNLVQLSDAY STGSSLMPQK KNPDSLELIR
SKAGRVFGRC AGLLMTLKGL PSTYNKDLQE DKEAVFEVSN TMSAVIQVAT GVISTLQIHR
ENMARALSPD MLATDLAYYL VRKGMPFRQA HEASGKAVFM AETKGVALNQ LSLQELQTIS
PLFSGDVSHV WDYGHSVEQY AALGGTARSS VDWQIGQVRA LLGAQQA
//
