ID A0A2Y9PFG3_DELLE Unreviewed; 1546 AA.
AC A0A2Y9PFG3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 {ECO:0000313|RefSeq:XP_022445664.1, ECO:0000313|RefSeq:XP_030618625.1};
GN Name=ARAP3 {ECO:0000313|RefSeq:XP_022445664.1,
GN ECO:0000313|RefSeq:XP_030618625.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022445664.1};
RN [1] {ECO:0000313|RefSeq:XP_022445664.1, ECO:0000313|RefSeq:XP_030618625.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022445664.1,
RC ECO:0000313|RefSeq:XP_030618625.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022445664.1; XM_022589956.1.
DR RefSeq; XP_030618625.1; XM_030762765.1.
DR STRING; 9749.A0A2Y9PFG3; -.
DR Ensembl; ENSDLET00000004002; ENSDLEP00000003545; ENSDLEG00000002782.
DR KEGG; dle:111183025; -.
DR OrthoDB; 4835at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd17902; ArfGap_ARAP3; 1.
DR CDD; cd13253; PH1_ARAP; 1.
DR CDD; cd13254; PH2_ARAP; 1.
DR CDD; cd04385; RhoGAP_ARAP; 1.
DR CDD; cd09490; SAM_Arap1_2_3; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037858; RhoGAP_ARAP.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45899:SF4; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 4.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 5.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 3.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 8..68
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 287..379
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 394..483
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 480..611
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 909..1090
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 1119..1212
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1225..1327
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 67..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1415..1546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..98
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1419..1450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1458..1475
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1510..1524
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1525..1546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1546 AA; 170282 MW; 9CC2550EA7A58F6F CRC64;
MAAPQDLDIA VWLATVHLEQ YADVFRRHGL ATAGAARGLG HEELRQLGIN ATGHRKRILR
LLQAGTAEGS PDPQLESAME PSPSPVPQAQ PPKPVPKPRT VFGGLSGPTT TQRPGLSPAL
WRPEASKSPE ASPRSPPVPQ RSSSEQPSAL NTVEMMPNAI YFGLDLRGGA QTAQDMAPDS
SQTTAPTPAL RPTTGTVHIM DPGCLYYGVQ PVGVPGVPDR REGRVICQER AEHRLSRQDL
EAREDAGYAS LELPGDSTLS LPALDAETND DLISPYASFS STADRPTPLL SGWLDKLSPQ
GNYVFQRRFV QFNGRSLMYF GSDKDPFPKG VIPLTAIEMT RSSKDNKFQV VTGQRVFVFR
TESEAQRDTW CSTVQSCLKE QRLLGHPRPP QPPRPLRTGM LELRGHKAKV FAALSPGELA
LYKSEQAFSL GIGICFIELQ GCSVRETKSR SFDLLTPHRC FSFTAESGGA RQSWAAALQE
AVTETLSDYE VAEKIWSNRA NRHCADCEAS RPDWAAVNLG VVICKQCAGQ HRALGSGISK
VQSLKLDTSV WSNEIVQLFI VLGNDRANRF WAGALPPGEG LHPDTTPGPR GEFISRKYRL
GLFRKPHPQY PDHSQLLQAL CTAVAGPNLL KNMTQLLCVE AFEGEEPWSP PALDGSFPGL
LPADPSPGVY NEVVVPAAYS SFLYCGPISN KAGPPPPRRG RDAPPRLWCV LGAALEMFVS
ESSPEPLNLI QPQDVVCLGV NPPPTDPGDL DRFPFSFELV LTGGRIQHFG TDGADSLEAW
TSAVGKWFSP LSCHQLLGPG LLRLGRLWLR SPSHTALAPG LWLSGFGLLR GDHLFLCPAS
GPGPPAPEDM VHLRRLQEIS VVSATDTPDK KEHLVLVETG RTLYLQAEGR LDFSAWNAAI
AGAAGGGGTG LQEQQMSRGD IPIIVDACIS FVTQHGLRLE GVYRKGGARA RSLRLLAEFR
RDARSVKLRP GEHFVEDVTD TLKRFFRELD DPVTSARLLP RWREAAELPQ KNQRLEKYKE
VIGCLPRVNR RTLATLIGHL YRVQKCAALN QMCTRNLALL FAPSVFQTDG RGEHEVRVLQ
ELIDGYISVF DIDPDQVAQI DLEVSLITTW KDVQLSQAGD LIMEVFIEQQ LPDNCVTLKV
SPTLTAEELT NQVLEIRGTA AGMDLWVTFE IRERGELERP LHPKERVLEQ ALQWCQLPEP
CSASLLLRKV SLAHAGCLFT GIRRESPRVG LLRCREEPPR LLGNRFQERF FLLRGRCLLL
LKEKKSSKPE REWPLEGAKV YLGIRKKFKP PSPWGFTLIL EKMHLYLSCT DEDEMWDWAT
SILKAQHDDQ QPVVLRRRSS SDLARQKFGT MPLLPIRGDD SGATLLSANQ TLRRLHNRRT
LSMFFPMKSS QGSVEEQEEL EEPVYEEPVY EEVGAFPELT EDTSTSFSIT PERTAKPETP
LASQRSFDQS PLPKAGPLGW EERPPEPPPG PPSKSSPQSH GSLEEQLLQE LSSLILRKGE
TTVGLGSPSQ PSSPQPPSPN GLPTQTPGFP TQAPCTSSPS PSQPLT
//
