ID A0A2Y9PFN5_DELLE Unreviewed; 324 AA.
AC A0A2Y9PFN5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Probable UDP-sugar transporter protein SLC35A4 {ECO:0000256|ARBA:ARBA00040184};
DE AltName: Full=Solute carrier family 35 member A4 {ECO:0000256|ARBA:ARBA00041939};
GN Name=SLC35A4 {ECO:0000313|RefSeq:XP_022444685.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022444685.1};
RN [1] {ECO:0000313|RefSeq:XP_022444685.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022444685.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CDP(out) + CDP-L-ribitol(in) = CDP(in) + CDP-L-ribitol(out);
CC Xref=Rhea:RHEA:71579, ChEBI:CHEBI:57608, ChEBI:CHEBI:58069;
CC Evidence={ECO:0000256|ARBA:ARBA00036682};
CC -!- SUBUNIT: Found in a complex with SLC35A2 and SLC35A3.
CC {ECO:0000256|ARBA:ARBA00038552}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC subfamily. {ECO:0000256|ARBA:ARBA00009976}.
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DR RefSeq; XP_022444685.1; XM_022588977.2.
DR AlphaFoldDB; A0A2Y9PFN5; -.
DR STRING; 9749.A0A2Y9PFN5; -.
DR Ensembl; ENSDLET00000009669; ENSDLEP00000008756; ENSDLEG00000006412.
DR KEGG; dle:111182535; -.
DR InParanoid; A0A2Y9PFN5; -.
DR OrthoDB; 4641608at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3730.20; -; 1.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR PANTHER; PTHR10231; NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER; 1.
DR PANTHER; PTHR10231:SF96; UDP-SUGAR TRANSPORTER PROTEIN SLC35A4-RELATED; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022597}.
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 54..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 324 AA; 34446 MW; 80D41520AC6C709D CRC64;
MSVEDGGVPG LGHPRQARWT LMLLLSTAMY GAHAPLLALC HVDGRVPFRP SSAVLLTELT
KLLLCAFSLL VGWQAWPQQT PPWRQAAPFA LSALLYGASN NLVIYLQRYM DPSTYQVLSN
LKIGSTALFY CLCLRHRLSA RQGLALLLLI AAGACYAAGG LQDPGNTLPG PPSAAAAGPM
PLHISPLGLL LLILYCLISG LSSVYTELLM KRQRLPLALQ NLFLYTFGVL LNLGLHAGGG
PGPGLLEGFS GWAALVVLSQ ALNGLLMSAV MKHGSSITRL FVVSCSLVVN AVLSAALLQL
QLTAAFFLAT LLIGLAVRLY YGSR
//
