ID   A0A2Y9PG64_DELLE        Unreviewed;       929 AA.
AC   A0A2Y9PG64;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Exocyst complex component 2 {ECO:0000256|ARBA:ARBA00017526, ECO:0000256|RuleBase:RU365069};
GN   Name=EXOC2 {ECO:0000313|RefSeq:XP_022442227.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022442227.1};
RN   [1] {ECO:0000313|RefSeq:XP_022442227.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022442227.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC       exocytic vesicles with fusion sites on the plasma membrane.
CC       {ECO:0000256|ARBA:ARBA00002660, ECO:0000256|RuleBase:RU365069}.
CC   -!- SUBUNIT: Component of the exocyst complex.
CC       {ECO:0000256|RuleBase:RU365069}.
CC   -!- SIMILARITY: Belongs to the SEC5 family. {ECO:0000256|ARBA:ARBA00010578,
CC       ECO:0000256|RuleBase:RU365069}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_022442227.1; XM_022586519.2.
DR   AlphaFoldDB; A0A2Y9PG64; -.
DR   STRING; 9749.A0A2Y9PG64; -.
DR   Ensembl; ENSDLET00000001410; ENSDLEP00000001215; ENSDLEG00000000911.
DR   KEGG; dle:111181295; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0000145; C:exocyst; IEA:UniProtKB-UniRule.
DR   GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR   GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR   GO; GO:0006893; P:Golgi to plasma membrane transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:2000535; P:regulation of entry of bacterium into host cell; IEA:Ensembl.
DR   GO; GO:0006904; P:vesicle docking involved in exocytosis; IEA:Ensembl.
DR   CDD; cd00603; IPT_PCSR; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR029175; EXOC2/Sec5.
DR   InterPro; IPR039481; EXOC2/Sec5_N_dom.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   PANTHER; PTHR13043:SF1; EXOCYST COMPLEX COMPONENT 2; 1.
DR   PANTHER; PTHR13043; EXOCYST COMPLEX COMPONENT SEC5; 1.
DR   Pfam; PF15469; Sec5; 1.
DR   Pfam; PF01833; TIG; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
PE   3: Inferred from homology;
KW   Exocytosis {ECO:0000256|ARBA:ARBA00022483, ECO:0000256|RuleBase:RU365069};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|RuleBase:RU365069};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365069}.
FT   DOMAIN          8..91
FT                   /note="IPT/TIG"
FT                   /evidence="ECO:0000259|Pfam:PF01833"
FT   DOMAIN          133..914
FT                   /note="Exocyst complex component EXOC2/Sec5 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF15469"
SQ   SEQUENCE   929 AA;  103931 MW;  B1F8E213F00FBE44 CRC64;
     MSRTRQPPLV TGISPNEGIP WTKVTIRGEN LGTGPADLIG LTICGHNCLL TAEWMSPSKI
     VCRVGQAKND KGDIIVTTKS GGKGTSTVSF KLLRPEKIGI LDQSAVWVDE MNYYDMRTDR
     NKGIPPLSLR PANPLGIEIE KGKFPQKDLE MLFPGMSADF TSENFSAAWY LIENHSNTSF
     EQLKMAVTHL KRQANKKSEG SLACVKGGLS TFFEAQDALS AIHQKLEADG TEKVEGSMTQ
     KLENVLHRAS NTADTLFQEV LGRKDKADST RNALNVLQRF KFLFNLPLSI ERNIQKGDYD
     VVINDYEKAK SLFGKTEVQV FKKYYAEVET RIEALRELLL DKLLETPSTL HDQKRYIRYL
     SDLHAPGDPA WQCIGAQHRW ILQLMHSCQE GCVRDLKGPP GLHSATLDLD GDVRASLPGH
     LGQTASLKRG SSFQPGRDDA WRYQTPHRVA FVEKLTKLVL SQLPNFWKLW ISYVNGSLFS
     ETAEKSGHIE RSKNVRQRQN DFKKMIQEVM HCLVKLLRGA LLPLSVTEGG GRQCRGWEVK
     AELSGQGLAH AIQTLRLTYE SLTALEIPND LLQTIQDLVL DLRVRCVVVT LQHTAEEVKR
     LAEKEDWVVD SEGLTSLPCH FELCVVHSLQ SLREVLECKP GEASVFQQPK TQEEVCQLSI
     NIMQVFICCL EQLSTKPDAD VDTAHLSVDV SSPDLFGSVH EDFSLTSEQR LLIVLSNCCY
     LERHTFRNIA EHFEKHNFQG IEKITQVSMA SLKELDQRLF ENYIELKADP IVGSLEPGIY
     AGYFDWKDCL PPTGVRNYLK EALVNIIAVH AEVFTISKGL VPRVLSRLVE AVSEELSRLM
     QCVSSFSKNG ALQARLEICT LRDTVAAHLT PESRSSFKQA LEALPQLSSG ADRKLLELLL
     SRVRSGVHLQ LACFQAAPPP AVKTQVPSR
//