ID A0A2Y9PG67_DELLE Unreviewed; 735 AA.
AC A0A2Y9PG67;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=CCR4-NOT transcription complex subunit 3 isoform X3 {ECO:0000313|RefSeq:XP_022441633.1};
GN Name=CNOT3 {ECO:0000313|RefSeq:XP_022441633.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022441633.1};
RN [1] {ECO:0000313|RefSeq:XP_022441633.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022441633.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC cellular mRNA deadenylases and is linked to various cellular processes
CC including bulk mRNA degradation, miRNA-mediated repression,
CC translational repression during translational initiation and general
CC transcription regulation. Additional complex functions may be a
CC consequence of its influence on mRNA expression. May be involved in
CC metabolic regulation; may be involved in recruitment of the CCR4-NOT
CC complex to deadenylation target mRNAs involved in energy metabolism.
CC Involved in mitotic progression and regulation of the spindle assembly
CC checkpoint by regulating the stability of MAD1L1 mRNA. Can repress
CC transcription and may link the CCR4-NOT complex to transcriptional
CC regulation; the repressive function may involve histone deacetylases.
CC Involved in the maintenance of embryonic stem (ES) cell identity.
CC {ECO:0000256|PIRNR:PIRNR005290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|PIRNR:PIRNR005290}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005290}.
CC Note=NANOS2 promotes its localization to P-body.
CC {ECO:0000256|PIRNR:PIRNR005290}.
CC -!- SIMILARITY: Belongs to the CNOT2/3/5 family.
CC {ECO:0000256|ARBA:ARBA00007682, ECO:0000256|PIRNR:PIRNR005290}.
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DR RefSeq; XP_022441633.1; XM_022585925.2.
DR AlphaFoldDB; A0A2Y9PG67; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0030015; C:CCR4-NOT core complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:2000036; P:regulation of stem cell population maintenance; IEA:UniProt.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.30.1020; CCR4-NOT complex subunit 2/3/5, C-terminal domain; 1.
DR InterPro; IPR038635; CCR4-NOT_su2/3/5_C_sf.
DR InterPro; IPR012270; CCR4-NOT_su3/5.
DR InterPro; IPR040168; Not2/3/5.
DR InterPro; IPR007282; NOT2/3/5_C.
DR InterPro; IPR007207; Not_N.
DR PANTHER; PTHR23326; CCR4 NOT-RELATED; 1.
DR PANTHER; PTHR23326:SF1; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3; 1.
DR Pfam; PF04153; NOT2_3_5_C; 1.
DR Pfam; PF04065; Not3; 1.
DR PIRSF; PIRSF005290; NOT_su_3_5; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005290};
KW Developmental protein {ECO:0000256|PIRNR:PIRNR005290};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR005290};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|PIRNR:PIRNR005290};
KW RNA-mediated gene silencing {ECO:0000256|PIRNR:PIRNR005290};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR005290};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR005290};
KW Translation regulation {ECO:0000256|PIRNR:PIRNR005290}.
FT DOMAIN 4..233
FT /note="CCR4-Not complex component Not N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04065"
FT DOMAIN 604..729
FT /note="NOT2/NOT3/NOT5 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04153"
FT REGION 241..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..393
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 735 AA; 80374 MW; 59B13C0D0FD4DE67 CRC64;
MADKRKLQGE IDRCLKKVSE GVEQFEDIWQ KLHNAANANQ KEKYEADLKK EIKKLQRLRD
QIKTWVASNE IKDKRQLIDN RKLIETQMER FKVVERETKT KAYSKEGLGL AQKVDPAQKE
KEEVGQWLTN TIDTLNMQVD QFESEVESLS VQTRKKKGDK DQKQDRIEGL KRHIEKHRYH
VRMLETILRM LDNDSILVDA IRKIKDDVEY YVDSSQDPDF EENEFLYDDL DLEDIPQALV
ATSPPSHSHM EDEIFNQSSS TPTSTTSSSP IPPSPANCTT ENSEDDKKRG RSTDSEISQS
PAKNGSKPVH SSQHPQSPAV PPSYPSGPPP AASALSTAPG NNGAPAPAAP PSALGAKASP
APSHSSGTPA PYAQAVAPPA PSGPSPAQPR PPSVQPGGGG GGGKQNGATS YSSVVADSPA
EVALSSGGGS SANSQALGPP SGPHNPPPST SKEPNATAPT GAGGVAPGSG NNSGGPSLLV
PLPVNPPSSP TPSFNEAKAA GALLNGPPQF SAAPEIKAPE PLSSLKSMAE RAAISSGIED
PVPTLHLTER DIILSSTSAP PASAQPALQL SEVNIPLSLG VCPLGPVPLT KEQLYQQAME
EAAWHHMPHP SDSERIRQYL PRNPCPTPPY HHQMPPPHSD TVEFYQRLST ETLFFIFYYL
EGTKAQYLAA KALKKQSWRF HTKYMMWFQR HEEPKTITDE FEQGTYIYFD YEKWGQRKKE
GFTFEYRYLE DRDLQ
//
