ID A0A2Y9PGR1_DELLE Unreviewed; 1481 AA.
AC A0A2Y9PGR1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Regulating synaptic membrane exocytosis protein 1 isoform X17 {ECO:0000313|RefSeq:XP_022446124.1};
GN Name=RIMS1 {ECO:0000313|RefSeq:XP_022446124.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022446124.1};
RN [1] {ECO:0000313|RefSeq:XP_022446124.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022446124.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022446124.1; XM_022590416.2.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:InterPro.
DR CDD; cd04031; C2A_RIM1alpha; 1.
DR CDD; cd04028; C2B_RIM1alpha; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR039032; Rim-like.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12157; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN; 1.
DR PANTHER; PTHR12157:SF18; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 1; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF02318; FYVE_2; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 59..119
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 553..639
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 690..813
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1327..1445
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 131..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 818..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 871..959
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 991..1110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1197..1220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1234..1263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..412
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..678
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..858
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..913
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 927..948
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 991..1007
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1009..1045
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1197..1211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1234..1249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1481 AA; 164678 MW; 2DCAE355629D24CD CRC64;
MRPRCVVRDM VKPAACKTPR NVEHQPHQPS PRLHQQFESY KEQVRKIGEE ARRYQGEHKD
DAPTCGICHK TKFADGCGHL CSYCSTKFCA RCGGRVSLRS NNEDKVVMWV CNLCRKQQEI
LTKSGAWFFG SGPQQPSQDG TLSDTATGAG SEAPREKKSR LQERSRSQTP LSTATASPQD
QVPHSVPPDR RKGAEPSQQA GRPEQKQASF RSRSEPPRDR KKTPGLAEQN GKGAPKGERK
RAPRSSGQPT EGLTEERERK ERRESRRLEK GRSQDYPDVP EKRENGPAVE AEKQRKEEEY
QTRYRSDPNL ARYPVKPPPE EQQMRMHARM SRARHERRHS DVALPRTEAA AGPEGRPGPR
APNAARGSPP ASPRAYSAER TAEARAPGAP PLAEPSPPAP RPGPGPADAP EPRAPEPLRK
QSRLDPGAAV LVRKAKREKV ETMLRNDSLS SDQSESVRPS PPKPHRAKRG GKRRQMSVSS
SEEEGVSTPE YTSCEDVELE SESVSEKGDL DYYWLDPATW HSRETSPISS HPVTWQPSKE
GDRLIGRVIL NKRTTMPKES GALLGLKVVG GKMTDVGRLG AFITKVKKGS LADVVGHLRA
GDEVLEWNGK PLPGATNEEV YNIILESKSE PQVEIIVSRP IGDIPRIPES SHPPLESSSS
SFESQKMERP SISVISPTSP GALKDAPQVL PGQLSVKLWY DKVGHQLIVN VLQATDLPPR
VDGRPRNPYV KMYFLPDRSD KSKRRTKTVK KVLEPKWNQT FVYSHVHRRD FRERMLEITV
WDQPRVQEEE SEFLGEILIE LETALLDDEP HWYKLQTHDE SSLPLPQPSP FMPRRHVHGE
SASKKLQRSQ RISDSDISDY EVDDAIGVVP PVGYRSGARE SKPSTLTVPE QQRTTHHRSR
SVSPHRGDDQ GRPRSRLPNV PLQRSLDEIH PTRRSRSPTR HHDVSCSPVG HRPGDVDSQC
LSEQDSELLM LPRAKRGRSA ECLHTTSDLQ PSLDRARSAS TNCLRPDASL HSPERERHSR
KSERSSTQKQ TRKGTASDAE RVHRQASPTR SPPADTAFGS PRGRQLPQVP GRSGSAEQAS
LVVEERTRQM KMKVHRFKQT TGSGSSRELD REQYSKYNVH TDQYRSCDSV SARSSDSDVS
DVSAISRTSS TSFLSEQSER PRGRTSSFTP KMQGRRMGTS GRAITKSTSV SGEMYTLEHN
DGSQSDTAVG TVGTGGKKRR SSLSAKVVAI VTRRSRSTSQ LSQTESGHKK LKSTIQRSTE
TGMAAEMRKM VRQPSRESTD GSINSYSSEG NLIFPGVRLG VDSQFSDFLD GLGPAQLVGR
QTLATPAMGD IQIGMEDKKG QLEVEVIRAR SLTQKPGSKS TPAPYVKVYL LENGACIAKK
KTRIARKTLD PLYQQSLVFD ESPQGKVLQV IVWGDYGRMD HKCFMGVAQI LLEELDLSSM
VIGWYKLFPP SSLVEPTLTP LTRRASQSSL ESSTGPPCIR S
//
