ID A0A2Y9PGU8_DELLE Unreviewed; 1164 AA.
AC A0A2Y9PGU8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=AF4/FMR2 family member 4 {ECO:0000313|RefSeq:XP_022444495.1, ECO:0000313|RefSeq:XP_022444496.1};
GN Name=AFF4 {ECO:0000313|RefSeq:XP_022444495.1,
GN ECO:0000313|RefSeq:XP_022444496.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022444496.1};
RN [1] {ECO:0000313|RefSeq:XP_022444495.1, ECO:0000313|RefSeq:XP_022444496.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022444495.1,
RC ECO:0000313|RefSeq:XP_022444496.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
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DR RefSeq; XP_022444495.1; XM_022588787.2.
DR RefSeq; XP_022444496.1; XM_022588788.2.
DR STRING; 9749.A0A2Y9PGU8; -.
DR Ensembl; ENSDLET00000003887; ENSDLEP00000003437; ENSDLEG00000002716.
DR KEGG; dle:111182429; -.
DR OrthoDB; 4254515at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0000791; C:euchromatin; IEA:Ensembl.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0008023; C:transcription elongation factor complex; IEA:Ensembl.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR Gene3D; 6.10.250.2670; -; 1.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR043639; AF4_int.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF15; AF4_FMR2 FAMILY MEMBER 4; 1.
DR Pfam; PF05110; AF-4; 1.
DR Pfam; PF18875; AF4_int; 1.
DR Pfam; PF18876; AFF4_CHD; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 899..1162
FT /note="AF4/FMR2 C-terminal homology"
FT /evidence="ECO:0000259|Pfam:PF18876"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1074
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..401
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..585
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..649
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..707
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..794
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..869
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..894
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1060..1074
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1164 AA; 127420 MW; 090799D2A58F1924 CRC64;
MNREDRNVLR MKERERRNQE IQQGDDAFPP SSPLFAEPYK VTSKEDKLSS RIQSMLGNYD
EMKDFIGDRS IPKLVAIPKP TVPPTADEKS NPNFFEQRHG SSHQSSKWTP VGPAPSTSQS
QKRSSGLQSG HSSQRASAGA SSGANSSGQR HDRDSYSSGG SSSRKKGQHG SEHSKSRSSS
PGKPQAVSSL SSSHSRSHGN DHHSKEHQRS KSPRDPDANW DSPSRVPFSS GQHSNQSFPP
SLMSKSSSML QKPTAYVRPM DGQESMEPKL SSEHYSSQSH GNSMTELKPS SKAHLTKLKI
PSQPLDASAS GDVSCVDEIL KEMTHSWPPP LTAIHTPCKT EPSKFPFPTK ESQQSNFGPG
EQKRYNPSSK TSNGHQSKSM LKDDLKLSSS EDSDGEQDCD KTMPRSTPGS NSEPSHHNSE
GADNSRDDSS SHSGSESSSG SDSESESSSS DSEANEPSQS ASPEPEPPPT NKWQLDNWLN
KVNPHKVSPA SSVDSNIPSS QGYKKEGREQ GTGNSYTDPG GPKETSSATP GRDSKTVQKG
SESGRGRQKS PAQSDSTAQR RTVGKKQPKK TEKAAAEEPR GGLKIESETP VDMATSMPSG
RHKAATKGSR KPNIKKESKS SPRPSAEKKK YKSTSKSSQK SREIIETDTS SSDSDESESL
PPSSQTPKYP ESNRTPVKPS SVEEEDSFFR QRMFSPMEEK ELLSPLSEPD DRYPLIVKID
LNLLTRIPGK PYKETETPKG EKKNVPEKHT REAQKQASEK VSNKGKRKHK NEDDNRANES
KKPKTEDKNS AGHKPSSNKE SSKQSAAKEK DLLPSPAGPV PSKDPKTEHG SRKRTISQSS
SLKSSNNSNK ENSSSSKNSS STSKQKRTEG KTSSSSKEVK EKAPNSSSNC PPSTPTPDAS
KPRRTKLAFD DRNYSADHYL QEAKKLKHNA DALSDRFEKA VYYLDAVVSF IECGNALEKN
AQESKSPFLM YSETVELIKY TMKLKNYLAP DATAADKRLT VLCLRCQSLL YLRLFKLKKE
TALKYSKTLT EHLKNSYNNS QAPSPGLGSK AAGMPSPVSP KLSPGNSGNY SSGASSASAS
GSSVTIPQRI HHMAASYVQV TSNFLYATEI WDQAEQLSKE QKEFFAELDK VMGPLIFNAS
IMTDLVRYTR QGLHWLRQDA KLIS
//
