ID A0A2Y9PHB1_DELLE Unreviewed; 773 AA.
AC A0A2Y9PHB1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Dystrobrevin alpha isoform X8 {ECO:0000313|RefSeq:XP_022442651.1, ECO:0000313|RefSeq:XP_022442652.1};
GN Name=DTNA {ECO:0000313|RefSeq:XP_022442651.1,
GN ECO:0000313|RefSeq:XP_022442652.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022442652.1};
RN [1] {ECO:0000313|RefSeq:XP_022442651.1, ECO:0000313|RefSeq:XP_022442652.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022442651.1,
RC ECO:0000313|RefSeq:XP_022442652.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the dystrophin family. Dystrobrevin subfamily.
CC {ECO:0000256|ARBA:ARBA00009563}.
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DR RefSeq; XP_022442651.1; XM_022586943.2.
DR RefSeq; XP_022442652.1; XM_022586944.2.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd16249; EFh_DTNA; 1.
DR CDD; cd02334; ZZ_dystrophin; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR017432; Distrobrevin.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR015153; EF-hand_dom_typ1.
DR InterPro; IPR015154; EF-hand_dom_typ2.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR12268:SF19; DYSTROBREVIN ALPHA; 1.
DR PANTHER; PTHR12268; E3 UBIQUITIN-PROTEIN LIGASE KCMF1; 1.
DR Pfam; PF09068; EF-hand_2; 1.
DR Pfam; PF09069; EF-hand_3; 1.
DR Pfam; PF00569; ZZ; 1.
DR PIRSF; PIRSF038204; Distrobrevin; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 238..294
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT REGION 585..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 499..575
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 610..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..744
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 773 AA; 86993 MW; 762B687AB26860CB CRC64;
MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL HLVDIWNVIE
ALRENGLNNV DPNIELNVAR LEAVLSTIFY QLNKRMPTTH QIQVEQSISL LLNFLLAAFD
PEGHGKISVF AVKMALATLC GGKIMDKLRY IFSMISDSSG VMVYGRYDQF LREVLKLPTA
VFEGPSFGYT EQSARSCFSQ QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP
VECSYCHSES MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT
NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVDTWPPR PVTSMNDSMF SHSVPSSGSP
FITRRLPEGI SASSPVAEEH SLIKLYVNQL DHSARSPPKD SEVEQSKLLA RAAPALLKGK
GIQYSLNVAD RLADEHVLIG LYVNMLRNNP SCMLESSTRL DEEHRLIARY AARLAAEPTP
SQPAQQRSAP DISFTIDANK QQRQLIAELE NKNREILQEI QRLRLEHEQA SQPTPEKAQQ
NPTLLAELRL LRQRKDELEQ RMSALQESRR ELMVQLEGLM KLLKTQGAGS PRSSPSHTIS
RPIPMPVRSA SACSTPTHTP QDSLTGVGGD VQEAFAQSSR RNLRNDLLVA ADSITNTMSS
LVKELNSEAG SETESNVDSE LARTHFEDLV PSPTSEKAFL AQIHARKPGY LHSGATPSAM
RGDVVTEDGD PYVRPEDENY EDDSVRQLEN ELKMEEYLKQ KLQDEAYQVS LQG
//
