ID   A0A2Y9PHE2_DELLE        Unreviewed;       479 AA.
AC   A0A2Y9PHE2;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Islet cell autoantigen 1 isoform X2 {ECO:0000313|RefSeq:XP_022442678.1, ECO:0000313|RefSeq:XP_022442687.1};
GN   Name=ICA1 {ECO:0000313|RefSeq:XP_022442678.1,
GN   ECO:0000313|RefSeq:XP_022442687.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022442687.1};
RN   [1] {ECO:0000313|RefSeq:XP_022442678.1, ECO:0000313|RefSeq:XP_022442687.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022442678.1,
RC   ECO:0000313|RefSeq:XP_022442687.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_022442678.1; XM_022586970.2.
DR   RefSeq; XP_022442687.1; XM_022586979.2.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:InterPro.
DR   CDD; cd07661; BAR_ICA69; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR010504; AH_dom.
DR   InterPro; IPR024114; Islet_autoAg_Ica1/Ica1-like.
DR   InterPro; IPR006723; Islet_autoAg_Ica1_C.
DR   PANTHER; PTHR10164; ISLET CELL AUTOANTIGEN 1; 1.
DR   PANTHER; PTHR10164:SF3; ISLET CELL AUTOANTIGEN 1; 1.
DR   Pfam; PF06456; Arfaptin; 1.
DR   Pfam; PF04629; ICA69; 2.
DR   SMART; SM01015; Arfaptin; 1.
DR   SMART; SM01237; ICA69; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   PROSITE; PS50870; AH; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT   DOMAIN          50..253
FT                   /note="AH"
FT                   /evidence="ECO:0000259|PROSITE:PS50870"
FT   REGION          280..321
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          399..444
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        303..318
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        418..432
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   479 AA;  54264 MW;  1116831D52E409D0 CRC64;
     MSGHKCYPWD LHDRYAQDKS VVNKMQQKYW ETKQAFIKAT GKKEDEHVVA SDADLDAKLE
     LFHSIQRTCL DLSKAIVLYQ KRICFLSQEE NELGKFLRSQ GFQDKTRAGK MMQATGKALC
     FSSQQRLALR NPLCRFHQEV ETFRHRAISD TWLTVNRMEQ CRTEYRGALL WMKDVSQELD
     PDLYKQMEKF RKVQTQVRLA KKSFDKLKMD VCQKVDLLGA SRCNLLSHML ATYQTTLLHF
     WEKTSHTMAA IHESFKGYQP YEFTTLKSLQ DPMKKLVEKE EGKKIAQQES AEASVEEPSQ
     LISLEDENQH KESSSFKTED GKSVLSALDK SSIHNACSDE LLDMKLEEGA CLGPMAGTLE
     PEGADKDDLL LLSEIFNASS LEEGEFSKEW AAVFGDSRVK EPAPTAAPGE PDPKPQTGSG
     FLPSQLLDQN MKDLQASLEE PAKPSSDLTA WFSLFADLDP LSNPDAVGKT DKEHELLNA
//