ID A0A2Y9PIL7_DELLE Unreviewed; 935 AA.
AC A0A2Y9PIL7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Protocadherin gamma-C3 isoform X3 {ECO:0000313|RefSeq:XP_022445640.1};
GN Name=LOC111183016 {ECO:0000313|RefSeq:XP_022445640.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022445640.1};
RN [1] {ECO:0000313|RefSeq:XP_022445640.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022445640.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain. {ECO:0000256|ARBA:ARBA00003436}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_022445640.1; XM_022589932.2.
DR AlphaFoldDB; A0A2Y9PIL7; -.
DR Ensembl; ENSDLET00000002059; ENSDLEP00000001806; ENSDLEG00000001489.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF296; PROTOCADHERIN GAMMA-C3; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 693..719
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..136
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 137..245
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 246..353
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 354..458
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 459..568
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 581..686
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 804..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 935 AA; 101210 MW; 6778776B685AE9DB CRC64;
MVPEAWRSGL VSTGRVVGVL LLLGALHKAS AAVIRYEILE EREKGFAVGN VVRDLGLDLG
SLSARRLRVV SGASRRFFEV NWETGEMFVN DRLDREELCG TLPSCTITLE LVVERPLELF
SAEVVIQDIN DNNPSFPTRE MKLEISEAVA PGTRFPLESA HDPDVGSNSL QTYELSRNEY
FALRVQTRED STKYAELVLE RALDREREPD LQLVLTALDG GTPARSASLP IRIVVLDAND
NAPTFNQSLY RARVLEDAPP GTRVVQVHAT DLDEGPNGEI IYSFGSHNRA GVRELFSLDL
VTGVLTVKGR LDFEDAKLHE IYIQAKDKGA SPEGAHCKVL VEVVDVNDNA PEITVTSVYS
PVPEDAPLGT VIALLSVTDL DAGENGLVTC EVPPGLPFSL TSSLKNYFTL KTSAALDRET
VPEYNLSITA RDAGTPSLSA LTTVQVQVSD INDNPPQSSQ SSYDVYVEEN NLPGVPILNL
SVWDPDAPQN ARLSFFLLEQ GAEIGLVGRY FTINRDSGVV SSLVPLDHED RRAFELTAHI
SDGGTPVLAT NISVNIFVTD RNDNAPQVLY PRPGQSSVEM LPRGTSAGHV VTRVVGWDPD
AGHNAWLSYS LLGAPNQSLF AVGLHTGQVS TARPVQDTDS PRQTLTVLIK DNGEPSLSTT
ATLTVSVIEE SPEARAEFPS GSAPREQNKN LTFYLLLSLI LVSVGFAVTV LGVIVFKVYK
WKQSRDLYRA PVSSLYRTPG PSLHADAVRG GLLPPHLYHQ VYLTTDSRRS DPLLKKPGAA
SPLASRQNTL RSLDPVFYRQ VLGAESSPPG QQAPPNTDWR FSQAQRPGTS GSQNGDETGT
WPNNQFDTEM LQAMILASAS EAADGSSTLG GSAGTMGLSA RYGPQFTLQH VPDYRQNVYI
PGSNATLTNA AGKRDGKAPA GGNGNKKKSG KKEKK
//
