ID A0A2Y9PJW5_DELLE Unreviewed; 1941 AA.
AC A0A2Y9PJW5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Probable helicase with zinc finger domain isoform X1 {ECO:0000313|RefSeq:XP_022445575.1, ECO:0000313|RefSeq:XP_022445576.1};
GN Name=HELZ {ECO:0000313|RefSeq:XP_022445575.1,
GN ECO:0000313|RefSeq:XP_022445576.1, ECO:0000313|RefSeq:XP_022445577.1,
GN ECO:0000313|RefSeq:XP_022445578.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022445576.1};
RN [1] {ECO:0000313|RefSeq:XP_022445575.1, ECO:0000313|RefSeq:XP_022445576.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022445575.1,
RC ECO:0000313|RefSeq:XP_022445576.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022445575.1; XM_022589867.2.
DR RefSeq; XP_022445576.1; XM_022589868.2.
DR RefSeq; XP_022445577.1; XM_022589869.2.
DR RefSeq; XP_022445578.1; XM_022589870.2.
DR STRING; 9749.A0A2Y9PJW5; -.
DR Ensembl; ENSDLET00000015809; ENSDLEP00000014322; ENSDLEG00000010531.
DR KEGG; dle:111182922; -.
DR OrthoDB; 5405202at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd18077; DEXXQc_HELZ; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.1000.10; Zinc finger, CCCH-type; 1.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR049569; HELZ_DEAD-box_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF365; HELICASE WITH ZINC FINGER DOMAIN-RELATED; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF00642; zf-CCCH; 1.
DR SMART; SM00356; ZnF_C3H1; 1.
DR SUPFAM; SSF90229; CCCH zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|RefSeq:XP_022445575.1,
KW ECO:0000313|RefSeq:XP_022445576.1};
KW Helicase {ECO:0000313|RefSeq:XP_022445575.1,
KW ECO:0000313|RefSeq:XP_022445576.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723};
KW Nucleotide-binding {ECO:0000313|RefSeq:XP_022445575.1,
KW ECO:0000313|RefSeq:XP_022445576.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 178..206
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT ZN_FING 178..206
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 1248..1344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1376..1485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1522..1547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1611..1647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1733..1851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1867..1941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1390..1409
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1416..1435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1622..1643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1758..1825
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1873..1891
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1916..1941
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1941 AA; 218080 MW; 98235BDA5486C68F CRC64;
MEDRRAEKSC EQACESLKRQ DYEMTLKHCT EALLSLGQYS MADFTGPCPL EIESIKIESL
LYRIASFLQL KNYGQADEDC RHVLGEGLAK GDGTFQAVLC CMQLKGKLQL VSSILAKSLT
GESLNGMVTK DLTRLKILLT ETETATGNVL PGYHVEDLEE GSCNGWHFRP PPRGITSSEE
YTLCKRFLEQ GICRYGAQCT SAHSQEELAE WQKRYASRLI KLKQQNENKQ LSGSYMETLI
EKWMNSLSPE KVLSECIEGV KVEHNPDLSV TVNTKKSHQT WTFALTCKPA RMLYRVALLY
DAHRPHFSIV AISAGDSATQ VSQEVPENCQ EWIGGKMAQN GLDHYVYKVG IAFNTEIFGT
FRQTIVFDFG LEPVLMQRVM IDAASTEDLE YLMHAKQQLV TTAKRWDSSS KTIIDFEPNE
TTDLEKSLLI RYQIPLSADQ LFTQSVLDKS LTKTNYQSRL HDLLYIEEIA QYKEVSKFNL
KVQLQILASF MLTGVSGGAK YAQNGQLFGR FKLTETLSED TLAGRLVMTK VNAVYLLPVP
KEKLVQTQGT KEKVYEATIE EKTKEYIFLR ISRECCEELN LRPDYDTQVE LQFQLNRLPL
CEMHYALDRI KDNGVLFPDI TMTPTIPWSP NRQWDEQLDP RLNAKQKEAV LAVTTPLSIQ
LPPVLIIGPY GTGKTFTLAQ AVKHILQQQE TSRILICTHS NSAADLYIKD YLHPYVEAGN
PQARPLRVYF RNRWVKTVHP VVHQYCLISS AHSTFQMPQK EDILKHRVVV VTLNTSQYLC
QLDLEPGFFT HVLLDEAAQA MECETIMPLA LATKDTRVVL AGDHMQLSPF VYSEFARERN
LHVSLLDRLY EHYPAEFPCR ILLCENYRSH EAIINYTSEL FYEGKLMASG KQPAHKDFYP
LTFFTARGED VQEKNSTAFY NNAEVFEVVE RVEELRRKWP VAWGKLDDGS IGVVTPYADQ
VFRIRAELRK KRLSDVNVER VLNVQGKQFR VLFLSTVRTR HTCKHKQTPI KKKEQLLEDS
TEDLDYGFLS NYKLLNTAIT RAQSLVAVVG DPIALCSIGR CRKFWERFIA LCHENNSLHG
ITFEQIKAQL EALELKKTYV LNPLAPEFIP RALRVQHTGN TNRLQQSPPK GKSLHHIQND
HFQNDGIVQP NPSVLIGNPI RAYTPPPPLG PHPNLGKSPS PVQRIDPHTG TSILYVPAVY
GGNVVMSVPL PVPWTGYQGR FAVDPRIITH QAAMAYNMNL LQTHGRGSPI PYGLGHHPPV
SIGQTQNQHQ EKDQHEQSRN GKSDTNNPGP EINKIRTPEK KPTESKQMDL ESNPQNRSPE
SRPGVVYPKF HRKDNLNPRH INLPVPAPHA QYAVPSRHFH PLPQLPRPPF AIPQQHALSS
QQQNNLPEQP NQMPPHPNQG VPQQDPLGQP PPQLSAACQA GPNSAFFNTP VSHRPQSPPA
EAALPEQQPP PMLQGGHSPL RAIAQPGPIL PSHLNNFADE NPPGLPVGEA LDRVHGSVAL
EALRQQQARL QQWSEHHAYL SQGSVPYPHH HHPHPHPHLQ HLPQPPIGLH QPPVRADWKL
PSSAEDEAET ADSRFQDLIR ELSNRDQSET RELAEMPPPQ SRLLQYRQIQ TRSPPAVPSP
PSSADHSTHF SNFSDSSRDL EVASNPAFPQ RLPPQLFNSP FSLPSEHLAP PPLKCLAPDG
AWTFANLQQN RLMGPGFPYG LPPLPPRPPQ TPFVHMQSHQ PAVSQEPFHP LSARTVSSSS
LPSLEEYEPR GPGRPLYQRR ISSSSVQPCS EEVSTPQDSL AQCKELQDHN NQSSFNFSSP
ESWVNTTSST PYQNIPCNGS SRTAQPRELI APPKTGKPPE DHLKPENLEG SSSFNYSVLQ
HLGQFPPLMP NKQIAESASS SSQQSCGGSK PAMSYASALR APPKPRPPPE QAKKSSDPLS
LFQELSLGSS SGSNGFYSYF K
//
